ChemicalBook >> CAS DataBase List >>(2R)-2-[[6-[(3-Chloro-4-carboxyphenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol

(2R)-2-[[6-[(3-Chloro-4-carboxyphenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol

(2R)-2-[[6-[(3-Chloro-4-carboxyphenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol structure

CAS No.: 212844-54-7

Chemical Name:: (2R)-2-[[6-[(3-Chloro-4-carboxyphenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol

Synonyms: NG 95;CS-2003;PURVALANOL B;NG 95; NG95; NG-95;Purvalanol B, >=96%;Purvalanol B(NG 95);Purvalanol B, 10 mM in DMSO;(R)-2-Chloro-4-((2-((1-hydroxy-3-methylbutan-2-yl)amino)-9-isopropyl-9H-purin-6-yl)amino)benzo;(R)-2-CHLORO-4-(2-(1-HYDROXY-3-METHYLBUTAN-2-YLAMINO)-9-ISOPROPYL-9H-PURIN-6-YLAMINO)BENZOIC ACID;(2R)-2-((6-((3-Chloro-4-carboxyphenyl)amino)-9-(1-methylethyl)-9H-purin-2-yl)amino)-3-methyl-1-butanol

CBNumber:: CB1100440

Molecular Formula:: C20H25ClN6O3

Molecular Weight:: 432.9

MDL Number:: MFCD04118312

MOL File:: 212844-54-7.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-09-12 18:48:32

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(2R)-2-[[6-[(3-Chloro-4-carboxyphenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol Properties

Melting point	58.5 °C
Boiling point	660.6±65.0 °C(Predicted)
Density	1.43±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility	DMSO: 37 mg/mL, soluble
form	solid
pka	2.81±0.25(Predicted)
color	White to light yellow
InChIKey	ZKDXRFMOHZVXSG-HNNXBMFYSA-N
SMILES	CC(C)[C@H](CO)Nc1nc(Nc2ccc(C(O)=O)c(Cl)c2)c3ncn(C(C)C)c3n1
UNSPSC Code	12352200
NACRES	NA.77

SAFETY

Risk and Safety Statements

PPE	Eyeshields, Gloves, type N95 (US)
WGK Germany	3
Storage Class	11 - Combustible Solids

(2R)-2-[[6-[(3-Chloro-4-carboxyphenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol price More Price(72)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	P5234	Purvalanol B ≥97% (HPLC), solid	212844-54-7	1mg	$85.9	2025-07-31	Buy
Cayman Chemical	19115	Purvalanol B ≥95%	212844-54-7	1mg	$46	2026-04-30	Buy
Cayman Chemical	19115	Purvalanol B ≥95%	212844-54-7	5mg	$102	2026-04-30	Buy
Cayman Chemical	19115	Purvalanol B ≥95%	212844-54-7	10mg	$134	2026-04-30	Buy
Cayman Chemical	19115	Purvalanol B ≥95%	212844-54-7	25mg	$278	2026-04-30	Buy

Product number	Packaging	Price	Buy
P5234	1mg	$85.9	Buy
19115	1mg	$46	Buy
19115	5mg	$102	Buy
19115	10mg	$134	Buy
19115	25mg	$278	Buy

(2R)-2-[[6-[(3-Chloro-4-carboxyphenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol Chemical Properties, Uses, Production

Description

Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. Purvalanol B is a CDK inhibitor that most potently inhibits Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p35, and Cdk2/cyclin B (IC₅₀s = 6, 9, 6, and 6 nM, respectively). It is inactive against Cdk4/cyclin D1 as well as several other protein kinases. Purvalanol B is a 2,6,9-trisubstituted purine that, at micromolar doses, inhibits the growth of parasites, including Plasmodium.

Uses

Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. Purvalanol B is a CDK inhibitor that most potently inhibits Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p35, and Cdk2/cyclin B (IC50s = 6, 9, 6, and 6 nM, respectively). It is inactive against Cdk4/cyclin D1 as well as several other protein kinases. Purvalanol B is a 2,6,9-trisubstituted purine that, at micromolar doses, inhibits the growth of parasites, including Plasmodium.

Uses

Purvalanol B is a potent cyclin-dependent kinase 2 (CDK2) inhibitor. These cyclin-dependent kinases play key roles in the regulation of the cell cycle and small molecules that inhibit these proteins have therapeutic potential against various proliferative and neurodegenerative disorders.

Definition

ChEBI: Purvalanol B is a purvalanol. It has a role as a protein kinase inhibitor.

Biological Activity

Cyclin-dependent kinase inhibitor. IC 50 values are 6, 6, 9, > 10,000, and 6 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1 and cdk5-p35 respectively. Selective over a range of other protein kinases (IC 50 > 10,000 nM). Shown to have antiproliferative properties, mediated by p42/p44 MAPK.

storage

Store at +4°C

References

[1] SERA T. [Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors].[J]. Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 2007, 52 13 Suppl: 1812-1813.
[2] M KNOCKAERT. Intracellular targets of cyclin-dependent kinase inhibitors: identification by affinity chromatography using immobilised inhibitors.[J]. Chemistry & biology, 2000, 7 6: 411-422. DOI: 10.1016/s1074-5521(00)00124-1
[3] KRISTEN M BULLARD Susan M K Carolyn Broccardo. Effects of cyclin-dependent kinase inhibitor Purvalanol B application on protein expression and developmental progression in intra-erythrocytic Plasmodium falciparum parasites.[J]. Malaria Journal, 2015: 147. DOI: 10.1186/s12936-015-0655-x

(2R)-2-[[6-[(3-Chloro-4-carboxyphenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol Preparation Products And Raw materials

Raw materials

Preparation Products

(2R)-2-[[6-[(3-Chloro-4-carboxyphenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol Suppliers

Global Suppliers ( 121)

Supplier	Tel	Email	Country	ProdList	Advantage
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
Chembest Research Laboratories Limited	021-20908456	sales@BioChemBest.com	China	5996	61
Ascent Scientific	4401179829988	customerservice@ascentscientific.co.uk	United Kingdom	279	60
Shanghai Topbiochem Technology Co., Ltd	+86-21-60341587	sales@topbiochem.com	China	6166	58
Haoyuan Chemexpress Co., Ltd.	021-58950125	info@chemexpress.com	China	7545	61
SYN\|thesis med chem P/L	+86-021-50720296	service@synkinase.com	China	266	58
AdooQ BioScience, LLC	+1 (866) 930-6790	info@adooq.com	United States	2774	58
Bide Pharmatech Ltd.	400-164-7117 18317119277	product02@bidepharm.com	China	40000	60
Nanjing Chalf-Pharm Technology Co., Ltd.	025-57018978 18251899859	sales@chalf-pharm.com	China	5855	50
AdooQ Bioscience CHINA	025-58849295	info@adooq.cn	China	2981	60

Supplier	Advantage
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Chembest Research Laboratories Limited	61
Ascent Scientific	60
Shanghai Topbiochem Technology Co., Ltd	58
Haoyuan Chemexpress Co., Ltd.	61
SYN\|thesis med chem P/L	58
AdooQ BioScience, LLC	58
Bide Pharmatech Ltd.	60
Nanjing Chalf-Pharm Technology Co., Ltd.	50
AdooQ Bioscience CHINA	60

View Latest Price from (2R)-2-[[6-[(3-Chloro-4-carboxyphenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-07-27	Purvalanol B 212844-54-7	$65.00-139.00		98.95%	10g	TargetMol Chemicals Inc.
	2020-01-03	(2R)-2-[[6-[(3-CHLORO-4-CARBOXYPHENYL)AMINO]-9-(1-METHYLETHYL)-9H-PURIN-2-YL]AMINO]-3-METHYL-1-BUTANOL 212844-54-7	$6.60	1KG	97%-99%	1kg -1000kg	Career Henan Chemical Co

Purvalanol B
212844-54-7
$65.00-139.00
98.95%
TargetMol Chemicals Inc.

(2R)-2-[[6-[(3-CHLORO-4-CARBOXYPHENYL)AMINO]-9-(1-METHYLETHYL)-9H-PURIN-2-YL]AMINO]-3-METHYL-1-BUTANOL
212844-54-7
$6.60
97%-99%
Career Henan Chemical Co

(2R)-2-[[6-[(3-Chloro-4-carboxyphenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol Spectrum

(2R)-2-[[6-[(3-CHLORO-4-CARBOXYPHENYL)AMINO]-9-(1-METHYLETHYL)-9H-PURIN-2-YL]AMINO]-3-METHYL-1-BUTANOL(212844-54-7)¹HNMR

212844-54-7 ((2R)-2-[[6-[(3-Chloro-4-carboxyphenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol) Related Search:

Purvalanol a N,N-Diethylbenzamide Permethrin 6-Anilinopurine (2R)-2-[[6-[(3-Chloro-4-carboxyphenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol

3-Methyl-1-butanol

1of2

PURVALANOL B NG 95 (2R)-2-((6-((3-Chloro-4-carboxyphenyl)amino)-9-(1-methylethyl)-9H-purin-2-yl)amino)-3-methyl-1-butanol NG 95, (2R)-2-[[6-[(3-Chloro-4-carboxyphenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol Purvalanol B, >=96% (R)-2-Chloro-4-((2-((1-hydroxy-3-methylbutan-2-yl)amino)-9-isopropyl-9H-purin-6-yl)amino)benzo Purvalanol B(NG 95) (R)-2-CHLORO-4-(2-(1-HYDROXY-3-METHYLBUTAN-2-YLAMINO)-9-ISOPROPYL-9H-PURIN-6-YLAMINO)BENZOIC ACID CS-2003 NG 95; NG95; NG-95 Benzoic acid, 2-chloro-4-[[2-[[(1R)-1-(hydroxymethyl)-2-methylpropyl]amino]-9-(1-methylethyl)-9H-purin-6-yl]amino]- Purvalanol B, 10 mM in DMSO (2R)-2-[[6-[(3-Chloro-4-carboxyphenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol 212844-54-7 C20H25ClN6O3 Cyclin-Dependent Kinase (CDK) Serine/Threonine Kinase Inhibitors Kinase/Phosphatase Biology Cell Signaling and Neuroscience Cell Biology BioChemical Signalling