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D-Biotin p-nitrophenyl ester

D-Biotin p-nitrophenyl ester Structure
D-Biotin p-nitrophenyl ester structure
CAS No.
33755-53-2
Chemical Name:
D-Biotin p-nitrophenyl ester
Synonyms
BNP;PBNP;BIOTIN-ONP;(+)-Biotin-ONP;Biotin-ONp Novabiochem;BIOTIN P-NITROPHENYL ESTER;Biotin π-nitrophenyl ester;4-NITROPHENYL (+)-BIOTINATE;biotinyl-4-nitrophenyl ester;D-Biotin p-nitrophenyl ester
CBNumber:
CB1101472
Molecular Formula:
C16H19N3O5S
Molecular Weight:
365.4
MDL Number:
MFCD15141972
MOL File:
33755-53-2.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:48:34
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D-Biotin p-nitrophenyl ester Properties

Melting point 163-165 °C(lit.)
Boiling point 642.9±50.0 °C(Predicted)
Density 1.326±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
solubility methanol: soluble25mg/mL, clear, colorless to greenish-yellow
pka 13.89±0.40(Predicted)
form Solid
color White to Off-White
biological source mouse
optical activity [α]25/D +51°, c = 2 in DMF: AcOH (99:1)
BRN 5795805
InChI 1S/C16H19N3O5S/c20-14(24-11-7-5-10(6-8-11)19(22)23)4-2-1-3-13-15-12(9-25-13)17-16(21)18-15/h5-8,12-13,15H,1-4,9H2,(H2,17,18,21)/t12-,13-,15-/m0/s1
InChIKey YUDNXDTXQPYKCA-OWYJLGKBSA-N
SMILES [O-][N+](=O)c1ccc(OC(=O)CCCC[C@@H]2SCC3NC(=O)NC23)cc1
CAS DataBase Reference 33755-53-2
UNSPSC Code 41123300
NACRES NA.41

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)
GHS05
Signal word  Warning
Hazard statements  H290
Precautionary statements  P234-P390
PPE Eyeshields, Gloves, type N95 (US)
Safety Statements  22-24/25
WGK Germany  3
F  10-21
HS Code  29349990
Storage Class 11 - Combustible Solids

D-Biotin p-nitrophenyl ester price More Price(79)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich WH0004879M1 Monoclonal Anti-NPPB antibody produced in mouse clone 2D11, purified immunoglobulin, buffered aqueous solution 33755-53-2 100μG $580 2026-04-30 Buy
Sigma-Aldrich SAB5300236 Monoclonal Anti-NPPB antibody produced in mouse clone 3A6F7C7, ascites fluid 33755-53-2 100μL $580 2026-04-30 Buy
Sigma-Aldrich SAB5300235 Monoclonal Anti-NPPB antibody produced in mouse clone 9H6B4, ascites fluid 33755-53-2 100μL $580 2026-04-30 Buy
Sigma-Aldrich RAB0386 Brain Natriuretic Peptide EIA Kit for serum, plasma, culture supernatant and cell lysates 1KIT $577 2026-04-30 Buy
Sigma-Aldrich 861650 (+)-Biotin 4-nitrophenyl ester 98% 33755-53-2 100mg $112 2026-04-30 Buy
Product number Packaging Price Buy
WH0004879M1 100μG $580 Buy
SAB5300236 100μL $580 Buy
SAB5300235 100μL $580 Buy
RAB0386 1KIT $577 Buy
861650 100mg $112 Buy

D-Biotin p-nitrophenyl ester Chemical Properties, Uses, Production

Chemical Properties

White to off-white powder

Uses

(+)-Biotin 4-nitrophenyl ester may be used in the preparation of biotin tagged ARC (adenosine-oligoarginine conjugate) derivative during cellular protein uptake studies. It may also be used to prepare biotinylated quinazoline derivatives, which shows inhibitory activities against VEGFR-2 (vascular endothelial growth factor receptor-2) tyrosine kinase. (+)-Biotin 4-nitrophenyl ester undergoes hydrolysis in the presence of Na[17O]H to form [17O2]biotin, which can be used in solid-state 17O NMR spectroscopic experiments to analyze large protein-ligand complexes.

Uses

For research use only. Not for use in diagnostic procedures.
Brain natriuretic peptide EIA Kit has been used to measure brain natriuretic peptide (BNP) secreted in human neonatal ventricular cardiomyocyte culture.

General Description

The BNP Enzyme Immunoassay (EIA) Kit is an in vitro quantitative assay for detecting BNP peptide based on the principle of Competitive Enzyme Immunoassay.

reaction suitability

reaction type: Biotinylations

Biochem/physiol Actions

Brain natriuretic peptide (BNP) expressed in mammalian brain and atrial natriuretic peptide (ANP) facilitates various physiological functions including regulation of blood pressure and cardiac remodeling. BNP acts as a potential biomarker of high left ventricular end-diastolic pressure in patients with symptomatic left ventricular (LV) dysfunction. Elevated expression of BNP is observed in acute myocardial infarction (AMI) patients. BNP is also implicated in several biological functions such as diuresis, natriureis, hypotensive action and inhibition of aldosterone secretion.

Purification Methods

The ester has been recrystallised by dissolving 2g in 95% EtOH (30mL), heated to dissolve, then cooled in an ice-water bath. The crystals are collected, washed with ice-cold 95% EtOH (5mL) and dried over P2O5. The RF on silica plates (CHCl3/MeOH 19:1) is 0.19 [Bodanszky & Fagan J Am Chem Soc 99 235 1977].

Description

B-type Natriuretic Peptide Recombinant Human produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 32 amino acids and having a molecular mass of 3,500 Dalton. NPPB is purified by proprietary chromatographic techniques. 

Source

Escherichia Coli

Background

Natriuretic Peptide Precursor B acts as a cardiac hormone with a variety of biological actions including natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. It is thought to play a key role in cardiovascular homeostasis. Helps restore the body's salt and water balance. Improves heart function.

D-Biotin p-nitrophenyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

6-N-Biotinylaminohexanol

D-Biotin p-nitrophenyl ester Suppliers

Global Suppliers ( 146)
Supplier Tel Email Country ProdList Advantage
Hunan Dikanza Pharmaceutical Technology Co., Ltd. 0731-15574352414 15574352414 chenjiawei155477@gmail.com China 27 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Suzhou Highfine Biotech Co., Ltd 0512-69209928 18796809688 zhouyingxiang@highfine.com China 472 75
Chemsky（shanghai）International Co.,Ltd. 021-50135380 shchemsky@sina.com China 32273 50
Beijing Isomersyn Technology CO;LTD 010-82954736 13391601435 sales@isomersyn.com China 3294 57
ChemPep, Inc. +1 (888) 615-9178 / (561) 791-8787 service@chempep.com United States 2138 57
Shanghai Sunway Pharmaceutical Technology Co., Ltd 13761987713 hxzheng@sunwaypharm.cn China 8663 57
Hangzhou Sage Chemical Co., Ltd. +86057186818502 13588463833 info@sagechem.com China 10265 58
Supplier Advantage
Hunan Dikanza Pharmaceutical Technology Co., Ltd. 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
TCI (Shanghai) Development Co., Ltd. 81
Suzhou Highfine Biotech Co., Ltd 75
Chemsky（shanghai）International Co.,Ltd. 50
Beijing Isomersyn Technology CO;LTD 57
ChemPep, Inc. 57
Shanghai Sunway Pharmaceutical Technology Co., Ltd 57
Hangzhou Sage Chemical Co., Ltd. 58

View Latest Price from D-Biotin p-nitrophenyl ester manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
D-BIOTIN P-NITROPHENYL ESTER pictures 2026-07-10 D-BIOTIN P-NITROPHENYL ESTER
33755-53-2
 1KG 98% 1000kgs Shaanxi Dideu New Materials Co. Ltd
(+)-Biotin-ONP pictures 2026-05-11 (+)-Biotin-ONP
33755-53-2
 99.91% 10g TargetMol Chemicals Inc.
D-BIOTIN P-NITROPHENYL ESTER pictures 2024-08-15 D-BIOTIN P-NITROPHENYL ESTER
33755-53-2
 $1.00 1KG 99% 20T Shaanxi Dideu Medichem Co. Ltd

D-Biotin p-nitrophenyl ester Spectrum

D-BIOTIN P-NITROPHENYL ESTER(33755-53-2)MSD-BIOTIN P-NITROPHENYL ESTER(33755-53-2)1HNMRD-BIOTIN P-NITROPHENYL ESTER(33755-53-2)IR1D-BIOTIN P-NITROPHENYL ESTER(33755-53-2)Raman

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PBNP 4-NITROPHENYL (+)-BIOTINATE BIOTIN P-NITROPHENYL ESTER BIOTIN-ONP BNP d-Biotin p-nitrophenyl ester D-(+)-Biotin 4-nitrophenyl ester BIOTIN-ONP D-Biotin p-nitrophenyl ester biotinyl-4-nitrophenyl ester Human B-type Natriuretic Protein 4-Nitrophenyl (+)-biotinate, d-Biotin p-nitrophenyl ester, BNP 1,1'-Binaphthyl-2,2'-diyl phosphate 4-Hydroxy-3,5-dioxa-4-phospha(V)-3H-cyclohepta[2,1-a:3,4-a']dinaphthalene-4-one 4-Hydroxy-4-oxodinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin 4-Hydroxydinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-one Phosphoric acid 1,1'-binaphthalene-2,2'-diyl ester (4-nitrophenyl) 5-[(3aR,6S,6aS)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-6-yl]pentanoate 5-[(3aR,6S,6aS)-2-keto-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-6-yl]valeric acid (4-nitrophenyl) ester Biotin π-nitrophenyl ester Monoclonal Anti-NPPB antibody produced in mouse (+)-Biotin 4-nitrophenyl ester 98% BNP, D-Biotin 4-nitrophenyl ester 4-Nitrophenyl 5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoate Biotinp-nitrophenyl ester≥ 99% (HPLC) Biotin-ONp Novabiochem (+)-Biotin4-NitrophenylEster> (+)-Biotin-ONP (+)-Biotin 4-nitrophenyl ester, 98%, (+)-Biotin 4-Nitrophenyl Ester Brain Natriuretic Peptide EIA Kit BNP D-Biotin p-nitrophenyl ester 33755-53-2 Chiral Building Blocks Asymmetric Synthesis Complex Molecules cytokine Biotin