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4-Chloro-2-anisidine hydrochloride

4-Chloro-2-anisidine hydrochloride Structure
4-Chloro-2-anisidine hydrochloride structure
CAS No.
93-50-5
Chemical Name:
4-Chloro-2-anisidine hydrochloride
Synonyms
4-Chloro-2-methoxyaniline;4-CHLORO-O-ANISIDINE;p-Chloro-o-anisidine;2-Amino-5-chloroanisole;2-Methoxy-4-chloroaniline;4-Chloro-o-anisidine (NH2=1);4-Chloro-2-methoxyaniline 98%;4-chloro-2-methoxy-benzenamin;4-chloro-2-methoxybenzenamine;4-Chloro-2-methoxybenzeneamine
CBNumber:
CB8435071
Molecular Formula:
C7H8ClNO
Molecular Weight:
157.6
MDL Number:
MFCD06801386
MOL File:
93-50-5.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:55:43
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4-Chloro-2-anisidine hydrochloride Properties

Melting point 52°C
Boiling point 260°C (rough estimate)
Density 1.1760 (rough estimate)
refractive index 1.5430 (estimate)
storage temp. Keep in dark place,Inert atmosphere,2-8°C
solubility Chloroform (Slightly), Methanol (Slightly)
pka 3.90±0.10(Predicted)
form Solid
color Dark Brown
CAS DataBase Reference 93-50-5(CAS DataBase Reference)
FDA UNII TV9MZ8W6NF
EPA Substance Registry System Benzenamine, 4-chloro-2-methoxy- (93-50-5)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P305+P351+P338
Hazard Codes  Xi
Risk Statements  43
Safety Statements  36/37
Hazard Note  Irritant/Keep Cold
TSCA  TSCA listed
HS Code  2921420090

4-Chloro-2-anisidine hydrochloride price More Price(71)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Usbiological 233016 4-Chloro-2-anisidine hydrochloride ≥95% (HPLC) ≥95%(HPLC) 93-50-5 250mg $245 2026-06-03 Buy
Usbiological 233016 4-Chloro-2-anisidine hydrochloride ≥95% (HPLC) ≥95%(HPLC) 93-50-5 1g $347 2026-06-03 Buy
Usbiological 233016 4-Chloro-2-anisidine hydrochloride ≥95% (HPLC) ≥95%(HPLC) 93-50-5 2.5g $588 2026-06-03 Buy
Usbiological 006360 4-Chloro-2-methoxyaniline 93-50-5 250mg $446 2026-06-03 Buy
Biosynth FC20021 4-Chloro-2-methoxyaniline 93-50-5 500mg $150 2026-06-04 Buy
Product number Packaging Price Buy
233016 250mg $245 Buy
233016 1g $347 Buy
233016 2.5g $588 Buy
006360 250mg $446 Buy
FC20021 500mg $150 Buy

4-Chloro-2-anisidine hydrochloride Chemical Properties, Uses, Production

Chemical Properties

Dark Brown Low Melting Solid

Uses

4-Chloro-2-methoxyaniline is an important intermediate used for the synthesis of CXCR2 antagonists and some CD4-gp120 binding inhibitors.

Synthesis

5-CHLORO-2-NITROANISOLE

6627-53-8

4-CHLORO-2-ANISIDINE HYDROCHLORIDE

93-50-5

General procedure: Make a suspension of iron powder (5.0 eq.), ammonium chloride (0.65 eq.) and distilled water and reflux for 15 minutes. 2-Nitro-5-chloroanisole (1.0 eq.) was added slowly and the reaction mixture continued to be stirred under reflux conditions. The progress of the reaction was monitored by thin layer chromatography (TLC) and when the reaction was complete, the reaction mixture was neutralized by slow dropwise addition of 5% aqueous sodium bicarbonate, followed by filtration through diatomaceous earth. The filtrate was extracted three times with ethyl acetate. The organic phases were combined and washed once each with saturated saline and 5% aqueous hydrochloric acid, in that order. The aqueous phases were combined, the pH was adjusted to neutral with 20% aqueous sodium hydroxide, and then extracted three times with ethyl acetate. The organic phases were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure to remove the solvent. The product can be purified by mixed solvent column chromatography with ethyl acetate/hexane or used directly as a crude product. Product purity was confirmed by 1H-NMR. Example 1: The crude 4-chloro-2-methoxyaniline was obtained as a dark purple oil (1.15 g, 91% yield) from the reaction of iron powder (2.23 g, 40 mmol), ammonium chloride (278 mg, 5.2 mmol), water (48 mL), and 5-chloro-2-nitroanisole (1.5 g, 8.0 mmol) for 1.5 h. The reaction was carried out by 1H NMR ( 300MHz, CDCl3): δ 6.78 (m, 2H), 6.65 (d, 1H), 3.86 (s, 3H). Example 2: 4-Chloro-2-methoxyaniline crude was obtained as a dark purple oil (2.35 g, 93% yield) after reacting for 2 hours with iron powder (4.47 g, 80.0 mmol), ammonium chloride (556 mg, 10.4 mmol), water (80 mL) and 5-chloro-2-nitroanisole (3.0 g, 16.0 mmol). No 1H-NMR analysis was performed.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 14, p. 3864 - 3867
[2] ChemMedChem, 2014, vol. 9, # 5, p. 962 - 972
[3] Patent: WO2006/71730, 2006, A1. Location in patent: Page/Page column 79; 80
[4] Patent: WO2014/28805, 2014, A1. Location in patent: Page/Page column 65
[5] Patent: WO2004/37789, 2004, A2. Location in patent: Page 312

4-Chloro-2-anisidine hydrochloride synthesis

67-56-1
100-00-5
93-50-5
Synthesis of 4-Chloro-2-anisidine hydrochloride from Methanol and 4-Chloronitrobenzene

4-Chloro-2-anisidine hydrochloride Preparation Products And Raw materials

Raw materials

1,3-bis(2-methoxyphenyl)urea 5-Chloro-2-fluoroanisole 5-Chloro-2-methoxyaniline 4-Chloro-2-methoxybenzoic acid 5-Chloro-2-nitroanisole
2-Amino-5-chlorophenol 2-Nitroanisole Methanol o-Anisidine 4-Chloronitrobenzene

1of2

Preparation Products

4-Chloro-2-anisidine hydrochloride Suppliers

Global Suppliers ( 152)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Shijiazhuang Sdyano Fine Chemical Co., Ltd. 0311-89250318 13582355795 master@sjzsdyn.com China 2776 65
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Shanghai Harvest Chemical Industrial Co., Ltd. 15721252604 17321035817 sales@harvest-chem.com China 2829 64
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Chemsky（shanghai）International Co.,Ltd. 021-50135380 shchemsky@sina.com China 32273 50
China Langchem Inc. 0086-21-58956006 China 7798 57
Tianjin Jinyuda Chemical Co., Ltd. 022-58013646 13011382049 sales@jinyudachem.com China 1976 55
T&W GROUP 021-61551611 13296011611 contact@trustwe.com China 9884 58
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Energy Chemical 61
Shijiazhuang Sdyano Fine Chemical Co., Ltd. 65
Wuhan Chemwish Technology Co., Ltd 56
Shanghai Harvest Chemical Industrial Co., Ltd. 64
Shanghai Hanhong Scientific Co.,Ltd. 64
Chemsky（shanghai）International Co.,Ltd. 50
China Langchem Inc. 57
Tianjin Jinyuda Chemical Co., Ltd. 55
T&W GROUP 58

View Latest Price from 4-Chloro-2-anisidine hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-Chloro-2-Methoxyaniline pictures 2026-09-16 4-Chloro-2-Methoxyaniline
93-50-5
 1KG 98%min 30tons/month WUHAN FORTUNA CHEMICAL CO., LTD
4-CHLORO-2-ANISIDINE HYDROCHLORIDE pictures 2025-12-24 4-CHLORO-2-ANISIDINE HYDROCHLORIDE
93-50-5
 1KG 99.0% 1000KG Shaanxi Dideu Medichem Co. Ltd
4-CHLORO-2-ANISIDINE HYDROCHLORIDE pictures 2019-09-02 4-CHLORO-2-ANISIDINE HYDROCHLORIDE
93-50-5
 $1.00 1KG 98% 1kg; 2kg；10kg; 100kg Career Henan Chemical Co

4-Chloro-2-anisidine hydrochloride Spectrum

4-CHLORO-2-ANISIDINE HYDROCHLORIDE(93-50-5)1HNMR4-CHLORO-2-ANISIDINE HYDROCHLORIDE(93-50-5)13CNMR4-CHLORO-2-ANISIDINE HYDROCHLORIDE(93-50-5)FT-IR

93-50-5 (4-Chloro-2-anisidine hydrochloride) Related Search:

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4-Chloro-2-methoxyaniline 98% 4-Chloro-o-anisidine (NH2=1) 1-Amino-4-chloro-2-methoxybenzene (4-chloro-2-methoxy-phenyl)amine 2-Methoxy-4-chloroaniline 4-Chloro-2-Methoxyaniline hydrochloride Benzenamine, 4-chloro-2-methoxy- 4-chloro-2-methoxy-benzenamin 4-CHLORO-O-ANISIDINE 4-CHLORO-O-ANISIDINE HYDROCHLORIDE 4-CHLORO-2-METHOXY-PHENYLAMINE HYDROCHLORIDE 4-CHLORO-2-METHOXYBENZENAMINE HYDROCHLORIDE p-Chloro-o-anisidine 2-Amino-5-chloroanisole 4-chloro-2-methoxybenzenamine 2-Amino-4-chloro-1-methoxybenzene 4-Chloro-2-methoxybenzeneamine 2-AMINO-5-CHLOROANISOLE HYDROCHLORIDE 4-Chloro-2-methoxyaniline 4-Chloro-2-anisidine hydrochloride 93-50-5 C7H8CINOHCl Amines blocks Aromatics Inhibitors Intermediates & Fine Chemicals Pharmaceuticals