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3-(1H-Imidazol-4-yl)pyridine

3-(1H-Imidazol-4-yl)pyridine structure

CAS No.: 51746-85-1

Chemical Name:: 3-(1H-Imidazol-4-yl)pyridine

Synonyms: CPD2017;CPDD2017;Brn 0003724;4-(3-Pyridyl)imidazol;4-(3-PYRIDYL)IMIDAZOLE;3-(4-Imidazolyl)Pyridine;3-(1H-IMidazol-5-yl)pyridine;3-(1h-imidazol-4-yl)-pyridin;3-(1H-IMIDAZOL-4-YL)PYRIDINE;3-(5-Imidazolyl)pyridine 95+%

CBNumber:: CB1106750

Molecular Formula:: C8H7N3

Molecular Weight:: 145.16

MDL Number:: MFCD01691712

MOL File:: 51746-85-1.mol

Last updated:2025-08-08 17:45:00

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3-(1H-Imidazol-4-yl)pyridine Properties

Melting point	117-118°C
Boiling point	422.4±20.0 °C(Predicted)
Density	1.214±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	Ethanol, Methanol, Water
form	Solid
pka	12.29±0.10(Predicted)
color	Light Yellow
InChI	InChI=1S/C8H7N3/c1-2-7(4-9-3-1)8-5-10-6-11-8/h1-6H,(H,10,11)
InChIKey	YFOKBFRTGLSZLU-UHFFFAOYSA-N
SMILES	C1=NC=CC=C1C1NC=NC=1
CAS DataBase Reference	51746-85-1(CAS DataBase Reference)
EWG's Food Scores	1

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H332-H335
Precautionary statements	P280-P305+P351+P338-P310
HazardClass	IRRITANT
HS Code	2933998090
Toxicity	mouse,LD50,intraperitoneal,250mg/kg (250mg/kg),BEHAVIORAL: GENERAL ANESTHETICLUNGS, THORAX, OR RESPIRATION: OTHER CHANGESBEHAVIORAL: EXCITEMENT,Quarterly Journal of Pharmacy & Pharmacology. Vol. 12, Pg. 260, 1939.

3-(1H-Imidazol-4-yl)pyridine price More Price(14)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Matrix Scientific	032282	3-(5-Imidazolyl)pyridine	51746-85-1	250mg	$144	2021-12-16	Buy
Matrix Scientific	032282	3-(5-Imidazolyl)pyridine	51746-85-1	1g	$359	2021-12-16	Buy
AK Scientific	7231AB	3-(1H-Imidazol-4-yl)pyridine	51746-85-1	500mg	$364	2021-12-16	Buy
SynQuest Laboratories	3H31-1-3B	3-(5-Imidazolyl)pyridine	51746-85-1	1g	$637	2021-12-16	Buy
Matrix Scientific	032282	3-(5-Imidazolyl)pyridine	51746-85-1	500mg	$233	2021-12-16	Buy

Product number	Packaging	Price	Buy
032282	250mg	$144	Buy
032282	1g	$359	Buy
7231AB	500mg	$364	Buy
3H31-1-3B	1g	$637	Buy
032282	500mg	$233	Buy

3-(1H-Imidazol-4-yl)pyridine Chemical Properties,Uses,Production

Chemical Properties

Light Yellow Solid

Uses

Imidazole rings are found in numberous natural compounds such as enzymes, nucleic acid, and alkaloids that play a role in biological processes.

Synthesis

93103-29-8

51746-85-1

General procedure for the synthesis of 3-(1H-imidazol-4-yl)pyridine from the compound (CAS:93103-29-8): 3-(1H-imidazol-4-yl)-4-(pyridin-3-yl)-1H-imidazole-2(3H)-thione (1.0 wt. portion; 1.00 equiv.), which had been prepared in step 3.1, was added to a reactor, followed by the addition of deionized water (8 vols. ). Sodium nitrite (0.58 wt. portions; 1.5 eq.) was added to the reactor, the reaction mixture was cooled to 5 °C and 65% nitric acid (1.97 vol. portions; 5 eq.) was added slowly. The inner wall of the reactor was rinsed with deionized water (2 vol. parts). The reaction mixture is heated to 35°C within 1 hour and stirred at that temperature for not less than 6 hours. In some embodiments, the reaction mixture may be heated to 85°C (e.g., for 3 hours, followed by stirring for an additional 2 hours). The mixture is cooled to 15°C and sodium carbonate (2.0 wt.) (or other base, such as sodium hydroxide) is slowly added. The solution was then heated to 30°C and saturated with sodium chloride. To the aqueous layer is added isopropanol (4 v/v) and stirred for no less than 30 minutes (the temperature may be increased in some embodiments during this process, e.g. to 55/60°C). The phases are separated, sodium chloride (2 wt. portions) is added to the aqueous layer, and the extraction of the aqueous layer is repeated once with isopropanol (4 vol. portions), and once more with isopropanol (2 vol. portions) (other solvents are optional, e.g., 2-methyltetrahydrofuran). The mixture was concentrated under vacuum to 2 vol%. The purity of the product was determined by HPLC and the structure was confirmed by NMR (see Figures 9 and 10). The yield was stable between 84-92% in multiple production runs.

References

[1] Patent: WO2014/17938, 2014, A2. Location in patent: Page/Page column 66

3-(1H-Imidazol-4-yl)pyridine Preparation Products And Raw materials

Raw materials

4-Iodoimidazole 3-Pyridineethanamine, β,β-dimethoxy- 5-PYRIDIN-3-YL-1H-IMIDAZOLE-2-THIOL formamide 3-Pyridylboronic acid

Sodium nitrite Nitric acid

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Preparation Products

3-(1H-Imidazol-4-yl)pyridine Suppliers

Global( 93)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Arbor Chemical Co., Ltd.	021-60451682	act@arborchemical.com	CHINA	904	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19552	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49975	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29800	58
CHEMSOON CO.,LTD.	+8613761723174	sales01@chemsoon.com	China	1211	58
SIMAGCHEM CORP	+86-5922680277 +86-13806087780	sale@simagchem.com	China	17346	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 +8617705817739	info@dycnchem.com	China	52846	58
Coresyn Pharmatech Co., Ltd.	+86-571-86626709 +86-18157142896	cbc@coresyn.com	China	9984	58
PT CHEM GROUP LIMITED	+86-85511178;	peter68@ptchemgroup.com	China	35425	58

Supplier	Advantage
Shanghai Arbor Chemical Co., Ltd.	58
BOC Sciences	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
CHEMSOON CO.,LTD.	58
SIMAGCHEM CORP	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
Coresyn Pharmatech Co., Ltd.	58
PT CHEM GROUP LIMITED	58

View Lastest Price from 3-(1H-Imidazol-4-yl)pyridine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2021-08-12	3-(1H-Imidazol-4-yl)pyridine 51746-85-1	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
2020-01-09	3-(1H-Imidazol-4-yl)pyridine 51746-85-1	US $3.00 / KG	1KG	98%	200KG	Career Henan Chemical Co
2020-01-09	3-(1H-Imidazol-4-yl)pyridine 51746-85-1	US $3.00 / KG	1KG	98%	200KG	Career Henan Chemical Co

3-(1H-Imidazol-4-yl)pyridine
51746-85-1
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

3-(1H-Imidazol-4-yl)pyridine
51746-85-1
US $3.00 / KG
98%
Career Henan Chemical Co

3-(1H-Imidazol-4-yl)pyridine
51746-85-1
US $3.00 / KG
98%
Career Henan Chemical Co

3-(1H-Imidazol-4-yl)pyridine Spectrum

3-(1H-Imidazol-4-yl)pyridine(51746-85-1)¹HNMR

51746-85-1(3-(1H-Imidazol-4-yl)pyridine)Related Search:

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4-(3-PYRIDYL)IMIDAZOLE 3-(1H-IMIDAZOL-4-YL)PYRIDINE 3-(1h-imidazol-4-yl)-pyridin 3-(5-Imidazolyl)pyridine 95+% 3-(1H-Imidazol-4-yl)pyridineDiscontinued See: I351751 4-(3-Pyridyl)imidazol Brn 0003724 Pyridine, 3-(1H-imidazol-4-yl)- 3-(1H-IMidazol-5-yl)pyridine Pyridine, 3-(1H-imidazol-5-yl)- 3-(1H-imidazole-4-yl)pyridine CPD2017 3-(1H-IMIDAZOL-4-YL)PYRIDINE DISCONTINUED 3-(4-Imidazolyl)Pyridine CPDD2017 1,4-Benzenedicarbonitrile,2,7-dibromo- 51746-85-1 C8H7N3SHCl Heterocycles Miscellaneous Reagents