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3-(1H-Imidazol-4-yl)pyridine

3-(1H-Imidazol-4-yl)pyridine Structure
3-(1H-Imidazol-4-yl)pyridine structure
CAS No.
51746-85-1
Chemical Name:
3-(1H-Imidazol-4-yl)pyridine
Synonyms
CPD2017;CPDD2017;Brn 0003724;4-(3-Pyridyl)imidazol;4-(3-PYRIDYL)IMIDAZOLE;3-(4-Imidazolyl)Pyridine;3-(1H-IMidazol-5-yl)pyridine;3-(1h-imidazol-4-yl)-pyridin;3-(1H-IMIDAZOL-4-YL)PYRIDINE;3-(5-Imidazolyl)pyridine 95+%
CBNumber:
CB1106750
Molecular Formula:
C8H7N3
Molecular Weight:
145.16
MDL Number:
MFCD01691712
MOL File:
51746-85-1.mol
MSDS File:
SDS
Last updated:2026-05-27 23:02:17
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3-(1H-Imidazol-4-yl)pyridine Properties

Melting point 117-118°C
Boiling point 422.4±20.0 °C(Predicted)
Density 1.214±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
solubility Ethanol, Methanol, Water
form Solid
pka 12.29±0.10(Predicted)
color Light Yellow
InChI InChI=1S/C8H7N3/c1-2-7(4-9-3-1)8-5-10-6-11-8/h1-6H,(H,10,11)
InChIKey YFOKBFRTGLSZLU-UHFFFAOYSA-N
SMILES C1=NC=CC=C1C1NC=NC=1
CAS DataBase Reference 51746-85-1(CAS DataBase Reference)
EWG's Food Scores 1

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H332-H335
Precautionary statements  P280-P305+P351+P338-P310
HazardClass  IRRITANT
HS Code  2933998090
Toxicity mouse,LD50,intraperitoneal,250mg/kg (250mg/kg),BEHAVIORAL: GENERAL ANESTHETICLUNGS, THORAX, OR RESPIRATION: OTHER CHANGESBEHAVIORAL: EXCITEMENT,Quarterly Journal of Pharmacy & Pharmacology. Vol. 12, Pg. 260, 1939.

3-(1H-Imidazol-4-yl)pyridine price More Price(30)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific OR318018 3-(5-Imidazolyl)pyridine 98% 51746-85-1 100mg $162 2026-06-04 Buy
Apolloscientific OR318018 3-(5-Imidazolyl)pyridine 98% 51746-85-1 250mg $270 2026-06-04 Buy
Apolloscientific OR318018 3-(5-Imidazolyl)pyridine 98% 51746-85-1 1g $680 2026-06-04 Buy
Apolloscientific OR318018 3-(5-Imidazolyl)pyridine 98% 51746-85-1 5g $2041 2026-06-04 Buy
Matrix Scientific 198772 3-(1H-Imidazol-4-yl)pyridine 51746-85-1 500.00mg $428 2026-05-18 Buy
Product number Packaging Price Buy
OR318018 100mg $162 Buy
OR318018 250mg $270 Buy
OR318018 1g $680 Buy
OR318018 5g $2041 Buy
198772 500.00mg $428 Buy

3-(1H-Imidazol-4-yl)pyridine Chemical Properties, Uses, Production

Chemical Properties

Light Yellow Solid

Uses

Imidazole rings are found in numberous natural compounds such as enzymes, nucleic acid, and alkaloids that play a role in biological processes.

Synthesis

5-PYRIDIN-3-YL-1H-IMIDAZOLE-2-THIOL

93103-29-8

3-(1H-Imidazol-4-yl)pyridine

51746-85-1

General procedure for the synthesis of 3-(1H-imidazol-4-yl)pyridine from the compound (CAS:93103-29-8): 3-(1H-imidazol-4-yl)-4-(pyridin-3-yl)-1H-imidazole-2(3H)-thione (1.0 wt. portion; 1.00 equiv.), which had been prepared in step 3.1, was added to a reactor, followed by the addition of deionized water (8 vols. ). Sodium nitrite (0.58 wt. portions; 1.5 eq.) was added to the reactor, the reaction mixture was cooled to 5 °C and 65% nitric acid (1.97 vol. portions; 5 eq.) was added slowly. The inner wall of the reactor was rinsed with deionized water (2 vol. parts). The reaction mixture is heated to 35°C within 1 hour and stirred at that temperature for not less than 6 hours. In some embodiments, the reaction mixture may be heated to 85°C (e.g., for 3 hours, followed by stirring for an additional 2 hours). The mixture is cooled to 15°C and sodium carbonate (2.0 wt.) (or other base, such as sodium hydroxide) is slowly added. The solution was then heated to 30°C and saturated with sodium chloride. To the aqueous layer is added isopropanol (4 v/v) and stirred for no less than 30 minutes (the temperature may be increased in some embodiments during this process, e.g. to 55/60°C). The phases are separated, sodium chloride (2 wt. portions) is added to the aqueous layer, and the extraction of the aqueous layer is repeated once with isopropanol (4 vol. portions), and once more with isopropanol (2 vol. portions) (other solvents are optional, e.g., 2-methyltetrahydrofuran). The mixture was concentrated under vacuum to 2 vol%. The purity of the product was determined by HPLC and the structure was confirmed by NMR (see Figures 9 and 10). The yield was stable between 84-92% in multiple production runs.

References

[1] Patent: WO2014/17938, 2014, A2. Location in patent: Page/Page column 66

3-(1H-Imidazol-4-yl)pyridine Preparation Products And Raw materials

Raw materials

4-Iodoimidazole 3-Pyridineethanamine, β,β-dimethoxy- 5-Pyridin-3-yl-1H-imidazole-2-thiol formamide 3-Pyridylboronic acid
Sodium nitrite Nitric acid

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Preparation Products

3-(1H-Imidazol-4-yl)pyridine Suppliers

Global Suppliers ( 100)
Supplier Tel Email Country ProdList Advantage
Yancheng Shunde Chemical Technology Co., Ltd. 13661532809; 13813431578 tianleyu@163.com China 80 58
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
China DongFan Chemical Co.,LTD 86-0571-85151182 China 5681 66
Shanghai Topbiochem Technology Co., Ltd 021-58170097 info@topbiochem.com China 9509 58
Shanghai T&W Pharmaceutical Co., Ltd. +86 21 61551611 China 9874 58
Shanghai Jian Chao Chemical Technology Co., Ltd. 150-2103-5486 18017383231 983544897@qq.com China 9335 55
Shanghai Aladdin Bio-Chem Technology Co.,LTD 400-6206333 13167063860 anhua.mao@aladdin-e.com China 29977 65
Shanghai Raise Chemical Technology Co.,Ltd +86-021-50935922 China 7854 55
Zhengzhou HSH Science & Technology Co., Ltd. 0371-55932928 18937192232; 1282296214@qq.com China 499 55
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 18149758185 sales-cpd@caerulumpharma.com China 3493 58
Supplier Advantage
Yancheng Shunde Chemical Technology Co., Ltd. 58
3B Pharmachem (Wuhan) International Co.,Ltd. 69
China DongFan Chemical Co.,LTD 66
Shanghai Topbiochem Technology Co., Ltd 58
Shanghai T&W Pharmaceutical Co., Ltd. 58
Shanghai Jian Chao Chemical Technology Co., Ltd. 55
Shanghai Aladdin Bio-Chem Technology Co.,LTD 65
Shanghai Raise Chemical Technology Co.,Ltd 55
Zhengzhou HSH Science & Technology Co., Ltd. 55
ShangHai Caerulum Pharma Discovery Co., Ltd. 58

View Latest Price from 3-(1H-Imidazol-4-yl)pyridine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3-(1H-Imidazol-4-yl)pyridine pictures 2021-08-12 3-(1H-Imidazol-4-yl)pyridine
51746-85-1
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd
3-(1H-Imidazol-4-yl)pyridine pictures 2020-01-09 3-(1H-Imidazol-4-yl)pyridine
51746-85-1
 $3.00 1KG 98% 200KG Career Henan Chemical Co
3-(1H-Imidazol-4-yl)pyridine pictures 2020-01-09 3-(1H-Imidazol-4-yl)pyridine
51746-85-1
 $3.00 1KG 98% 200KG Career Henan Chemical Co

3-(1H-Imidazol-4-yl)pyridine Spectrum

3-(1H-Imidazol-4-yl)pyridine(51746-85-1)1HNMR

51746-85-1 (3-(1H-Imidazol-4-yl)pyridine) Related Search:

2-(1H-Imidazol-4-yl)-pyridine 3-(3H-IMIDAZOL-4-YL)-PYRIDINE 2-(2-Pyridyl)-4-trifluoromethylimidazole 3-(1H-Imidazol-4-yl)pyridine Dihydrochloride 2-[4-[4-(3-Pyridinyl)-1H-imidazol-1-yl]butyl]-1H-isoindole-1,3(2H)-dione
3-(4-Trifluoromethyl-1H-imidazol-2-yl)pyridine 2-(4-Pyridyl)-4-trifluoromethylimidazole 4-[4-(3-Pyridyl)imidazol-1-yl]butylamine 3-(1H-Imidazol-4-yl)pyridine 2,6-Bis[1-(2-methylphenylimino)ethyl]pyridine
2-(1H-Imidazol-2-yl)-pyridine telithromycin 2-CHLORO-4-(1H-IMIDAZOL-2-YL)-PYRIDINE 2,6-Bis-(1H-imidazol-2-yl)-pyridine 3-Fluoro-2-(1H-imidazol-2-yl)-pyridine
3-(1H-Imidazol-2-yl)-pyridine 4-(1H-Imidazol-1-yl)pyridine-2-carboxylic acid 5-(4-Fluoro-phenyl)-4-pyridin-3-yl-1H-imidazole-2-thiol

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4-(3-PYRIDYL)IMIDAZOLE 3-(1H-IMIDAZOL-4-YL)PYRIDINE 3-(1h-imidazol-4-yl)-pyridin 3-(5-Imidazolyl)pyridine 95+% 3-(1H-Imidazol-4-yl)pyridine Discontinued See: I351751 4-(3-Pyridyl)imidazol Brn 0003724 Pyridine, 3-(1H-imidazol-4-yl)- 3-(1H-IMidazol-5-yl)pyridine Pyridine, 3-(1H-imidazol-5-yl)- 3-(1H-imidazole-4-yl)pyridine CPD2017 3-(1H-IMIDAZOL-4-YL)PYRIDINE DISCONTINUED 3-(4-Imidazolyl)Pyridine CPDD2017 1,4-Benzenedicarbonitrile,2,7-dibromo- 51746-85-1 C8H7N3SHCl Heterocycles Miscellaneous Reagents