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ChemicalBook >> CAS DataBase List >>4(1H)-Pyrimidinone, 5-fluoro-6-hydroxy-2-methyl- (9CI)

4(1H)-Pyrimidinone, 5-fluoro-6-hydroxy-2-methyl- (9CI)

4(1H)-Pyrimidinone, 5-fluoro-6-hydroxy-2-methyl- (9CI) Structure
4(1H)-Pyrimidinone, 5-fluoro-6-hydroxy-2-methyl- (9CI) structure
CAS No.
1598-63-6
Chemical Name:
4(1H)-Pyrimidinone, 5-fluoro-6-hydroxy-2-methyl- (9CI)
Synonyms
NSC 33038;5-Fluoro-4,6-dihydroxy-2-methylpyrimidine;5-Fluoro-6-hydroxy-2-methylpyrimidin-4(3H)-one;5-Fluoro-6-hydroxy-2-methyl-4(1H)-pyrimidinone;5-fluoro-4-hydroxy-2-methyl-1H-pyrimidin-6-one;5-Fluoro-6-hydroxy-2-methyl-4(3H)-pyrimidinone;4(3H)-PyriMidinone,5-fluoro-6-hydroxy-2-Methyl-;4(1H)-Pyrimidinone, 5-fluoro-6-hydroxy-2-methyl- (9CI);4(1H)-Pyrimidinone, 5-fluoro-6-hydroxy-2-methyl- (9CI) ISO 9001：2015 REACH
CBNumber:
CB11081649
Molecular Formula:
C5H5FN2O2
Molecular Weight:
144.1
MDL Number:
MFCD11520459
MOL File:
1598-63-6.mol
MSDS File:
SDS
Last updated:2025-07-24 18:13:45
Request For Quotation

4(1H)-Pyrimidinone, 5-fluoro-6-hydroxy-2-methyl- (9CI) Properties

Melting point >310℃
Density 1.59±0.1 g/cm3(Predicted)
storage temp. 2-8°C
pka 4.19±0.10(Predicted)
Appearance White to off-white Solid

SAFETY

Risk and Safety Statements

HazardClass  IRRITANT
HS Code  2933599590

4(1H)-Pyrimidinone, 5-fluoro-6-hydroxy-2-methyl- (9CI) price More Price(26)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Activate Scientific AS46555 5-Fluoro-6-hydroxy-2-methyl-4(1H)-pyrimidinone 96% 1598-63-6 1g $37 2026-06-04 Buy
Activate Scientific AS46555 5-Fluoro-6-hydroxy-2-methyl-4(1H)-pyrimidinone 96% 1598-63-6 5g $145 2026-06-04 Buy
Matrix Scientific 059836 5-Fluoro-2-methylpyrimidine-4,6-diol 1598-63-6 5.00g $49 2026-05-18 Buy
Synthonix F1383 5-Fluoro-2-methylpyrimidine-4,6-diol 96% 1598-63-6 250mg $13 2026-05-06 Buy
Synthonix F1383 5-Fluoro-2-methylpyrimidine-4,6-diol 96% 1598-63-6 100mg $15 2026-05-06 Buy
Product number Packaging Price Buy
AS46555 1g $37 Buy
AS46555 5g $145 Buy
059836 5.00g $49 Buy
F1383 250mg $13 Buy
F1383 100mg $15 Buy

4(1H)-Pyrimidinone, 5-fluoro-6-hydroxy-2-methyl- (9CI) Chemical Properties, Uses, Production

Synthesis

Dimethyl fluoromalonate

344-14-9

Acetamidine hydrochloride

124-42-5

4(1H)-Pyrimidinone, 5-fluoro-6-hydroxy-2-methyl- (9CI)

1598-63-6

Part A: Synthesis of 5-fluoro-4,6-dihydroxy-2-methylpyrimidine. A methanolic solution of 25% sodium methanolate (0.84 mol) was diluted in 200 mL of methanol. To this solution, acetamidine hydrochloride (40 g, 0.42 mol) was added and white precipitate formation was observed. Subsequently, dimethyl fluoromalonate (70 g, 0.46 mol) was added. The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the solvent was removed by vacuum concentration to give a dry residue. The residue was redissolved in 300 mL of hot water. After the aqueous solution was cooled to room temperature, concentrated hydrochloric acid was slowly added and the pH was adjusted to about 5. The formation of fine white prismatic crystals was observed. Concentrated hydrochloric acid was continued to be added dropwise to pH 3 and then the crystals were collected by filtration. The crystals were washed with 1 M hydrochloric acid and dried under vacuum to afford 5-fluoro-4,6-dihydroxy-2-methylpyrimidine (65.5 g, yield >100%).LCMS analysis showed (M + H)+: 145.

References

[1] Patent: WO2009/61879, 2009, A1. Location in patent: Page/Page column 60-61
[2] Patent: WO2013/82388, 2013, A1. Location in patent: Page/Page column 66-67

4(1H)-Pyrimidinone, 5-fluoro-6-hydroxy-2-methyl- (9CI) Preparation Products And Raw materials

Raw materials

Diethyl fluoromalonate Dimethyl fluoromalonate Acetamidine hydrochloride Sodium Methoxide Water
Methanol Hydrochloric acid

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Preparation Products

4(1H)-Pyrimidinone, 5-fluoro-6-hydroxy-2-methyl- (9CI) Suppliers

Global Suppliers ( 45)
Supplier Tel Email Country ProdList Advantage
Shanghai Topbiochem Technology Co., Ltd +86-21-60341587 sales@topbiochem.com China 6166 58
Shanghai T&W Pharmaceutical Co., Ltd. +86 21 61551611 China 9874 58
SynAsst Chemical. 021-60343070 China 12731 55
Shanghai Jovan Biochemical Technology Co. Ltd. +86-021-61654350 1245958370@qq.com China 2979 50
Shanghai Tombiopharma Chemical Co. Ltd. 13391076197 tombiopharma@163.com China 4986 55
SPIRO PHARMA eric_feng1954@126.com China 9239 55
ChengDu TongChuangYuan Pharmaceutical Co.Ltd 028-83379370 13880556291 tcy@tcypharm.com China 8696 58
Amadis Chemical Company Limited 571-89925085 sales@amadischem.com China 131885 58
Aikon International Limited 025-58859352 15955137747 sales01@aikonchem.com China 16021 58
Wuhan FengyaoTonghui Chemical Products Co., Ltd. 027-87466105 15377573527 2678564200@qq.com China 17968 58
Supplier Advantage
Shanghai Topbiochem Technology Co., Ltd 58
Shanghai T&W Pharmaceutical Co., Ltd. 58
SynAsst Chemical. 55
Shanghai Jovan Biochemical Technology Co. Ltd. 50
Shanghai Tombiopharma Chemical Co. Ltd. 55
SPIRO PHARMA 55
ChengDu TongChuangYuan Pharmaceutical Co.Ltd 58
Amadis Chemical Company Limited 58
Aikon International Limited 58
Wuhan FengyaoTonghui Chemical Products Co., Ltd. 58

View Latest Price from 4(1H)-Pyrimidinone, 5-fluoro-6-hydroxy-2-methyl- (9CI) manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4(1H)-Pyrimidinone, 5-fluoro-6-hydroxy-2-methyl- (9CI) pictures 2026-08-20 4(1H)-Pyrimidinone, 5-fluoro-6-hydroxy-2-methyl- (9CI)
1598-63-6
 $1.10 1g 99.00% 100 Tons Min Dideu Industries Group Limited

4(1H)-Pyrimidinone, 5-fluoro-6-hydroxy-2-methyl- (9CI) Spectrum

4(1H)-Pyrimidinone, 5-fluoro-6-hydroxy-2-methyl- (9CI)(1598-63-6)1HNMR

1598-63-6 (4(1H)-Pyrimidinone, 5-fluoro-6-hydroxy-2-methyl- (9CI)) Related Search:

4,6-Dihydroxy-2-methylpyrimidine 5-Chloro-6-hydroxy-2-MethylpyriMidin-4(3H)-one 2-Difluoromethyl-6-hydroxy-3H-pyrimidin-4-one 4(1H)-Pyrimidinone, 2-amino-5-fluoro-6-hydroxy- (9CI) 2-(1-Fluoroethyl)-6-hydroxypyrimidin-4(3H)-one
6-Hydroxy-2-(1-methylethyl)-4(3H)-pyrimidinone

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5-fluoro-4-hydroxy-2-methyl-1H-pyrimidin-6-one 5-Fluoro-6-hydroxy-2-methyl-4(1H)-pyrimidinone 4(1H)-Pyrimidinone, 5-fluoro-6-hydroxy-2-methyl- (9CI) 4(3H)-PyriMidinone,5-fluoro-6-hydroxy-2-Methyl- 5-Fluoro-4,6-dihydroxy-2-methylpyrimidine NSC 33038 5-Fluoro-6-hydroxy-2-methylpyrimidin-4(3H)-one 4(1H)-Pyrimidinone, 5-fluoro-6-hydroxy-2-methyl- (9CI) ISO 9001：2015 REACH 5-Fluoro-6-hydroxy-2-methyl-4(3H)-pyrimidinone 1598-63-6 PYRIMIDINE