ChemicalBook >> CAS DataBase List >>7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
- CAS No.
- 100361-18-0
- Chemical Name:
- 7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
- Synonyms
- 7-Chloro-1-cycloprop;Nalidixic acid cyclopropyl;7-Chloro-1-cyclopropyl-6-fluor;Gemifloxacin 7-Chloro Impurity;8-naphthyridine-3-carboxylic acid;7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1;1-Cyclopropyl-6-fluoro-7-chloride-4-oxo-1;7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-Ox;(S)-2-aMino-3-(2,4-diMethylphenyl)propanoic acid;1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyl ridine carbox.acid
- CBNumber:
- CB1114830
- Molecular Formula:
- C12H8ClFN2O3
- Molecular Weight:
- 282.65
- MDL Number:
- MFCD08458865
- MOL File:
- 100361-18-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
Last updated:2026-05-27 23:04:51
| Melting point | 209-212 °C |
|---|---|
| Boiling point | 485.9±45.0 °C(Predicted) |
| Density | 1.727±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| form | powder to crystal |
| pka | 5.96±0.70(Predicted) |
| color | White to Almost white |
| CAS DataBase Reference | 100361-18-0 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P | |||||||||
| HS Code | 2933998090 | |||||||||
| NFPA 704 |
|
7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid price More Price(43)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | C2650 | 7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid >98.0%(HPLC)(T) | 100361-18-0 | 1g | $46 | 2026-04-30 | Buy |
| TCI Chemical | C2650 | 7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid >98.0%(HPLC)(T) | 100361-18-0 | 5g | $227 | 2026-04-30 | Buy |
| Apolloscientific | PC301100 | 1-Cyclopropyl-6-fluoro-7-chloro-4-oxo-1,4-dihydro-1,8-napthyridine-3-carboxylic acid >98% | 100361-18-0 | 5g | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC301100 | 1-Cyclopropyl-6-fluoro-7-chloro-4-oxo-1,4-dihydro-1,8-napthyridine-3-carboxylic acid >98% | 100361-18-0 | 25g | $39 | 2026-06-04 | Buy |
| Apolloscientific | PC301100 | 1-Cyclopropyl-6-fluoro-7-chloro-4-oxo-1,4-dihydro-1,8-napthyridine-3-carboxylic acid >98% | 100361-18-0 | 100g | $130 | 2026-06-04 | Buy |
7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid Chemical Properties,Uses,Production
Chemical Properties
Off-white or light yellow powder
Uses
Gemifloxacin intermediate as antibacterial agent.
Synthesis
96568-07-9
100361-18-0
Ethyl 7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate (0.1 g, 0.32 mmol) was used as a raw material and dissolved in THF (5 ml). Concentrated HCl (45 μL, 0.7 mmol) was added to this solution. The reaction mixture was heated to reflux and the reaction was continued for 2 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming the completion of the reaction, the reaction mixture was cooled to room temperature. The precipitated solid was collected by filtration to afford the target product 7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid in a yield of 70 mg with 78% yield.
References
[1] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 7, p. 2428 - 2433
[2] Journal of Medicinal Chemistry, 2002, vol. 45, # 25, p. 5564 - 5575
[3] Patent: WO2005/40164, 2005, A1. Location in patent: Page/Page column 10-12
Synthesis of 7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid from 7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid Ethyl Ester
7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid Preparation Products And Raw materials
Global( 224)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
View Lastest Price from 7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-09-02 | 1-Cyclopropyl-6-fluoro-7-chloro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
100361-18-0
|
$1.00-50.00 | 1kg | 99 | Henan Fengda Chemical Co., Ltd | ||
 |
2025-12-29 | 7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
100361-18-0
|
1kg | 99% | Changzhou waston chemical technology Co.,Ltd | |||
 |
2025-06-27 | 7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
100361-18-0
|
1KG | 99% | 500000kg | Hebei Chuanghai Biotechnology Co., Ltd |
-
- 1-Cyclopropyl-6-fluoro-7-chloro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
100361-18-0
- $1.00-50.00
- 99
- Henan Fengda Chemical Co., Ltd
-
- 7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
100361-18-0
- $0.00
- 99%
- Changzhou waston chemical technology Co.,Ltd
-
- 7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
100361-18-0
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
100361-18-0(7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid)Related Search:
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1-Cyclopropyl-6-fluoro-7-chloride-4-oxo-1
7-Chloro-1-cycloprop
Nalidixic acid cyclopropyl
3-Carboxy-7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro[1,8]naphthyridine
(S)-2-aMino-3-(2,4-diMethylphenyl)propanoic acid
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1-Cyclopropyl-6-fluoro-7-chloro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid, 95+%
7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
1-CYCLOPROPYL-6-FLUORO-7-CHLORIDE-4-OXO-1,4-DIHYDRO-1,8-NAPTHYRIDINE-3-CARBOXYLIC ACID
7-Chloro-1-Cyclopropyl-6-Fluoro-4-Oxo-1,4-Dihydro-1,8-Naphthyridine-3-Carboxylic
1-Cyclopropyl-6-fluoro-7-chloro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
Gemifloxacin 7-Chloro Impurity
7-Chloro-1-Cyclopropyl-6-Fluoro-4-Oxo-1,4-Dihydro-1,8-Naphthyridine-3-CarboxylicAci
8-naphthyridine-3-carboxylic acid
7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1
7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid
100361-18-0
C12H8FClN2O3
Fluorine series
Heterocycles
Intermediate
Intermediates & Fine Chemicals
Pharmaceuticals
