7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid Ethyl Ester
- CAS No.
- 96568-07-9
- Chemical Name:
- 7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid Ethyl Ester
- Synonyms
- 4-dihydro-4-oxo-1;Ethyl 1-Cyclopropyl-;7-Chloro-1-cyclopropyl-6-fluoro-1;8-naphthyridine-3-carboxylic Acid Ethyl Ester;Ethyl 1-Cyclopropyl-6-Fluoro-7-Chloro-4-Oxo-1,;1-Cyclopropyl-6-fluoro-7-chloride-4-oxo-1,4-dihydro-1,8-napt...;ethyl 7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylate;1-Cyclopropyl-6-fluoro-7-chloride-4-oxo-1,4-dihydro-1,8-napthyridine-3-carboxylic;Ethyl1-Cyclopropyl-7-chloro-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthylrideincarboxylate;ETHYL 1-CYCLOPROPYL-7-CHLORO-6-FLUORO-1,4-DIHYDRO-4-OXO-1,8-NAPHTHYLRIDINE CARBOXYLATE
- CBNumber:
- CB3187124
- Molecular Formula:
- C14H12ClFN2O3
- Molecular Weight:
- 310.71
- MDL Number:
- MFCD08458313
- MOL File:
- 96568-07-9.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Ethyl 1-cyclopropyl-7-chloro-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine carboxylate | 29108 | 250MG | $60.39 |
| Ethyl 1-cyclopropyl-7-chloro-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine carboxylate | 29108 | 1G | $121.68 |
| Ethyl 1-cyclopropyl-7-chloro-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine carboxylate | 29108 | 5G | $392.19 |
| Ethyl 7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate | 074485 | 1.00g | $231 |
| Ethyl 7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate | 074485 | 5.00g | $599 |
| More product size | |||
7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid Ethyl Ester Properties
| Melting point | 172-174°C |
|---|---|
| Boiling point | 464.2±45.0 °C(Predicted) |
| Density | 1.511±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | -1.35±0.70(Predicted) |
| form | Solid |
| color | Light Tan |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2918300090 |
7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid Ethyl Ester price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Chem-Impex | 29108 | Ethyl 1-cyclopropyl-7-chloro-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine carboxylate | 96568-07-9 | 250MG | $60.39 | 2026-05-19 | Buy |
| Chem-Impex | 29108 | Ethyl 1-cyclopropyl-7-chloro-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine carboxylate | 96568-07-9 | 1G | $121.68 | 2026-05-19 | Buy |
| Chem-Impex | 29108 | Ethyl 1-cyclopropyl-7-chloro-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine carboxylate | 96568-07-9 | 5G | $392.19 | 2026-05-19 | Buy |
| Matrix Scientific | 074485 | Ethyl 7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate | 96568-07-9 | 1.00g | $231 | 2026-05-18 | Buy |
| Matrix Scientific | 074485 | Ethyl 7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate | 96568-07-9 | 5.00g | $599 | 2026-05-18 | Buy |
7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid Ethyl Ester Chemical Properties,Uses,Production
Chemical Properties
7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid Ethyl Ester is Light Tan Solid
Uses
7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid Ethyl Ester is a fluoroquinolone derivative used in the preparation of antibacterial agents.
Synthesis
![3-Pyridinepropanoic acid, 2,6-dichloro-α-[(cyclopropylamino)methylene]-5-fluoro-β-oxo-, ethyl ester](/CAS/20211123/GIF/96568-06-8.gif)
96568-06-8
96568-07-9
The general procedure for the synthesis of ethyl 7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-diazanaphthalene-3-carboxylate from ethyl 3-cyclopropylamino-2-(2,6-dichloro-5-fluoropyridine-3-carbonyl)acrylate (CAS: 96568-06-8) is as follows: at 75-80 °C, 7.0 g of 3-cyclopropylamino-2-( 2,6-dichloro-5-fluoropyridine-3-carbonyl)ethyl acrylate was dissolved in 35 mL of acetonitrile. Subsequently, 8.56 g (2.0 eq.) of K3PO4 was added to the reaction mixture in batches and stirred continuously at the same temperature for 1.5 hours. After completion of the reaction, the mixture was filtered under reduced pressure and the filter cake was washed with 77 mL of dichloromethane. The filtrate was concentrated under reduced pressure and the resulting residue was dissolved in 77 mL of dichloromethane and washed with deionized water. The organic layer was concentrated under reduced pressure to give 6.17 g of the target product ethyl 7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-diazanaphthalene-3-carboxylate in 98.5% yield. The structure of the product was confirmed by 1H NMR (CDCl3, ppm): 1.20 (4H, m, CH2CH2), 1.41 (3H, t, J=8 Hz, CH2CH3), 3.66 (1H, m, NCH), 4.41 (2H, q, J=8 Hz, CH2CH3), 8.44 (1H, d, J=4 Hz, C5-H). 8.66 (1H, s, C2-H).
References
[1] Patent: WO2004/56781, 2004, A1. Location in patent: Page 5-6
[2] Tetrahedron Letters, 1988, vol. 29, # 16, p. 1931 - 1934
[3] Patent: WO2004/56781, 2004, A1. Location in patent: Page 15
[4] Journal of Medicinal Chemistry, 1989, vol. 32, # 3, p. 537 - 542
[5] Journal of Medicinal Chemistry, 1992, vol. 35, # 3, p. 518 - 525
7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid Ethyl Ester Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29640 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 13901 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Jinan Finer Chemical Co., Ltd | +86-531-88989536 +86-15508631887 | sales@finerchem.com | China | 2950 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30225 | 58 |
| CD Chemical Group Limited | +8615986615575 | info@codchem.com | China | 17259 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25356 | 58 |
| Coresyn Pharmatech Co., Ltd. | +86-571-86626709 +86-18157142896 | cbc@coresyn.com | China | 9984 | 58 |
View Lastest Price from 7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid Ethyl Ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2025-12-29 | 7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid Ethyl Ester
96568-07-9
|
US $0.00 / kg | 1kg | 99% | As your request | Changzhou waston chemical technology Co.,Ltd | |
 |
2019-09-03 | 7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid Ethyl Ester
96568-07-9
|
US $7.00 / KG | 1KG | 99% | JD774 | Career Henan Chemical Co |
-
- 7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid Ethyl Ester
96568-07-9
- US $0.00 / kg
- 99%
- Changzhou waston chemical technology Co.,Ltd
-
- 7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid Ethyl Ester
96568-07-9
- US $7.00 / KG
- 99%
- Career Henan Chemical Co
96568-07-9(7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid Ethyl Ester)Related Search:
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