ChemicalBook >> CAS DataBase List >>7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid Ethyl Ester

7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid Ethyl Ester

7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid Ethyl Ester structure

CAS No.: 96568-07-9

Chemical Name:: 7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid Ethyl Ester

Synonyms: 4-dihydro-4-oxo-1;Ethyl 1-Cyclopropyl-;7-Chloro-1-cyclopropyl-6-fluoro-1;8-naphthyridine-3-carboxylic Acid Ethyl Ester;Ethyl 1-Cyclopropyl-6-Fluoro-7-Chloro-4-Oxo-1,;1-Cyclopropyl-6-fluoro-7-chloride-4-oxo-1,4-dihydro-1,8-napt...;ethyl 7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylate;1-Cyclopropyl-6-fluoro-7-chloride-4-oxo-1,4-dihydro-1,8-napthyridine-3-carboxylic;Ethyl1-Cyclopropyl-7-chloro-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthylrideincarboxylate;ETHYL 1-CYCLOPROPYL-7-CHLORO-6-FLUORO-1,4-DIHYDRO-4-OXO-1,8-NAPHTHYLRIDINE CARBOXYLATE

CBNumber:: CB3187124

Molecular Formula:: C14H12ClFN2O3

Molecular Weight:: 310.71

MDL Number:: MFCD08458313

MOL File:: 96568-07-9.mol

MSDS File:: SDS

Last updated:2026-05-28 01:02:03

Request For Quotation

7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid Ethyl Ester Properties

Melting point	172-174°C
Boiling point	464.2±45.0 °C(Predicted)
Density	1.511±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	-1.35±0.70(Predicted)
color	Light Tan

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
HS Code	2918300090

7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid Ethyl Ester price More Price(45)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Usbiological	275637	Ethyl 1-cyclopropyl-7-chloro-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthylridine carboxylate Asreported	96568-07-9	500mg	$375	2026-06-03	Buy
Usbiological	275637	Ethyl 1-cyclopropyl-7-chloro-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthylridine carboxylate Asreported	96568-07-9	1g	$526	2026-06-03	Buy
Usbiological	275637	Ethyl 1-cyclopropyl-7-chloro-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthylridine carboxylate Asreported	96568-07-9	2g	$721	2026-06-03	Buy
Usbiological	275637	Ethyl 1-cyclopropyl-7-chloro-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthylridine carboxylate Asreported	96568-07-9	5g	$991	2026-06-03	Buy
AK Scientific	V2197	Ethyl 1-cyclopropyl-7-chloro-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthylridine carboxylate 98%(HPLC)	96568-07-9	5g	$16	2026-06-04	Buy

Product number	Packaging	Price	Buy
275637	500mg	$375	Buy
275637	1g	$526	Buy
275637	2g	$721	Buy
275637	5g	$991	Buy
V2197	5g	$16	Buy

7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid Ethyl Ester Chemical Properties,Uses,Production

Chemical Properties

7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid Ethyl Ester is Light Tan Solid

Uses

7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid Ethyl Ester is a fluoroquinolone derivative used in the preparation of antibacterial agents.

Synthesis

3-Pyridinepropanoic acid, 2,6-dichloro-α-[(cyclopropylamino)methylene]-5-fluoro-β-oxo-, ethyl ester

96568-06-8

7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid Ethyl Ester

96568-07-9

The general procedure for the synthesis of ethyl 7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-diazanaphthalene-3-carboxylate from ethyl 3-cyclopropylamino-2-(2,6-dichloro-5-fluoropyridine-3-carbonyl)acrylate (CAS: 96568-06-8) is as follows: at 75-80 °C, 7.0 g of 3-cyclopropylamino-2-( 2,6-dichloro-5-fluoropyridine-3-carbonyl)ethyl acrylate was dissolved in 35 mL of acetonitrile. Subsequently, 8.56 g (2.0 eq.) of K3PO4 was added to the reaction mixture in batches and stirred continuously at the same temperature for 1.5 hours. After completion of the reaction, the mixture was filtered under reduced pressure and the filter cake was washed with 77 mL of dichloromethane. The filtrate was concentrated under reduced pressure and the resulting residue was dissolved in 77 mL of dichloromethane and washed with deionized water. The organic layer was concentrated under reduced pressure to give 6.17 g of the target product ethyl 7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-diazanaphthalene-3-carboxylate in 98.5% yield. The structure of the product was confirmed by 1H NMR (CDCl3, ppm): 1.20 (4H, m, CH2CH2), 1.41 (3H, t, J=8 Hz, CH2CH3), 3.66 (1H, m, NCH), 4.41 (2H, q, J=8 Hz, CH2CH3), 8.44 (1H, d, J=4 Hz, C5-H). 8.66 (1H, s, C2-H).

References

[1] Patent: WO2004/56781, 2004, A1. Location in patent: Page 5-6
[2] Tetrahedron Letters, 1988, vol. 29, # 16, p. 1931 - 1934
[3] Patent: WO2004/56781, 2004, A1. Location in patent: Page 15
[4] Journal of Medicinal Chemistry, 1989, vol. 32, # 3, p. 537 - 542
[5] Journal of Medicinal Chemistry, 1992, vol. 35, # 3, p. 518 - 525

7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid Ethyl Ester Preparation Products And Raw materials

Raw materials

3-Pyridinepropanoic acid, 2,6-dichloro-α-[(cyclopropylamino)methylene]-5-fluoro-β-oxo-, ethyl ester Potassium phosphate tribasic Acetonitrile

Preparation Products

7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid

7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid Ethyl Ester Suppliers

Global( 101)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32273	50
Beijing Isomersyn Technology CO;LTD	010-82954736 13391601435	sales@isomersyn.com	China	3294	57
China Langchem Inc.	0086-21-58956006		China	7798	57
Tongchuang Pharma(Suzhou). Co., Ltd.	0512-63263366 18912765016	tongtf110@sina.com	China	984	62
HBCChem, Inc.	+1-510-219-6317	sales@hbcchem.com	United States	10628	60
Bide Pharmatech Ltd.	400-164-7117 18317119277	product02@bidepharm.com	China	40000	60

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
Energy Chemical	61
Shanghai Hanhong Scientific Co.,Ltd.	64
Chemsky（shanghai）International Co.,Ltd.	50
Beijing Isomersyn Technology CO;LTD	57
China Langchem Inc.	57
Tongchuang Pharma(Suzhou). Co., Ltd.	62
HBCChem, Inc.	60
Bide Pharmatech Ltd.	60

View Lastest Price from 7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid Ethyl Ester manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-12-29	7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid Ethyl Ester 96568-07-9		1kg	99%		Changzhou waston chemical technology Co.,Ltd
	2019-09-03	7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid Ethyl Ester 96568-07-9	$7.00	1KG	99%		Career Henan Chemical Co

7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid Ethyl Ester
96568-07-9
$0.00
99%
Changzhou waston chemical technology Co.,Ltd

7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid Ethyl Ester
96568-07-9
$7.00
99%
Career Henan Chemical Co

96568-07-9(7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid Ethyl Ester)Related Search:

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ETHYL 1-CYCLOPROPYL-7-CHLORO-6-FLUORO-1,4-DIHYDRO-4-OXO-1,8-NAPHTHYLRIDINE CARBOXYLATE Ethyl 1-cyclopropyl-6-fluoro-7-chloro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate 7-CHLORO-1-CYCLOPROPYL-6-FLUORO-4-OXO-1,4-DIHYDRO-[1,8]NAPHTHYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER Ethyl 1-Cyclopropyl-6-Fluoro-7-Chloro-4-Oxo-1, ethyl-7-chloro-6-fluoro-1-cyclopropyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylate 1,8-NAPHTHYRIDINE-3-CARBOXYLICACID,7-CHLORO-1-CYCLOPROPYL-6-FLUORO-1,4-DIHYDRO-4-OXO-,ETHYLESTER Ethyl1-Cyclopropyl-7-chloro-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthylrideincarboxylate Ethyl 1-Cyclopropyl- Ethyl 7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate 7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid Ethyl Ester 4-dihydro-4-oxo-1 7-Chloro-1-cyclopropyl-6-fluoro-1 8-naphthyridine-3-carboxylic Acid Ethyl Ester ethyl 7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylate 1-Cyclopropyl-6-fluoro-7-chloride-4-oxo-1,4-dihydro-1,8-napt... 1-Cyclopropyl-6-fluoro-7-chloride-4-oxo-1,4-dihydro-1,8-napthyridine-3-carboxylic 96568-07-9 C14H12ClFN2O3 C14H12N2O3ClF