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ChemicalBook >> CAS DataBase List >>1,4-Oxazepin-5(2H)-one, 4-[3-[[2-[[2-ethyl-4-(4-methyl-1-piperazinyl)phenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]propyl]tetrahydro-

1,4-Oxazepin-5(2H)-one, 4-[3-[[2-[[2-ethyl-4-(4-methyl-1-piperazinyl)phenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]propyl]tetrahydro-

1,4-Oxazepin-5(2H)-one, 4-[3-[[2-[[2-ethyl-4-(4-methyl-1-piperazinyl)phenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]propyl]tetrahydro- Structure
1,4-Oxazepin-5(2H)-one, 4-[3-[[2-[[2-ethyl-4-(4-methyl-1-piperazinyl)phenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]propyl]tetrahydro- structure
CAS No.
2543673-19-2
Chemical Name:
1,4-Oxazepin-5(2H)-one, 4-[3-[[2-[[2-ethyl-4-(4-methyl-1-piperazinyl)phenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]propyl]tetrahydro-
Synonyms
Inlexisertib;SGR-1505/DCC3116;4-(3-((2-((2-ethyl-4-(4-methylpiperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)propyl)-1,4-oxazepan-5-one;1,4-Oxazepin-5(2H)-one, 4-[3-[[2-[[2-ethyl-4-(4-methyl-1-piperazinyl)phenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]propyl]tetrahydro-
CBNumber:
CB112017101
Molecular Formula:
C26H36F3N7O2
Molecular Weight:
535.6
MDL Number:
MOL File:
2543673-19-2.mol
MSDS File:
SDS
Last updated:2026-08-30 11:39:11
Request For Quotation

1,4-Oxazepin-5(2H)-one, 4-[3-[[2-[[2-ethyl-4-(4-methyl-1-piperazinyl)phenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]propyl]tetrahydro- Properties

Boiling point 736.6±70.0 °C(Predicted)
Density 1.266±0.06 g/cm3(Predicted)
pka 7.87±0.42(Predicted)
form Solid
color Light brown to brown
InChIKey CNBTYICEJGEABG-UHFFFAOYSA-N
SMILES O1CCC(=O)N(CCCNC2C(C(F)(F)F)=CN=C(NC3=CC=C(N4CCN(C)CC4)C=C3CC)N=2)CC1

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319
Precautionary statements  P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

1,4-Oxazepin-5(2H)-one, 4-[3-[[2-[[2-ethyl-4-(4-methyl-1-piperazinyl)phenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]propyl]tetrahydro- price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 45313 DCC-3116 ≥98% 2543673-19-2 1mg $39 2026-04-30 Buy
Cayman Chemical 45313 DCC-3116 ≥98% 2543673-19-2 5mg $185 2026-04-30 Buy
Cayman Chemical 45313 DCC-3116 ≥98% 2543673-19-2 10mg $293 2026-04-30 Buy
Cayman Chemical 45313 DCC-3116 ≥98% 2543673-19-2 50mg $683 2026-04-30 Buy
ChemScene CS-1013670 DCC-3116 99.84% 2543673-19-2 5mg $211 2026-06-04 Buy
Product number Packaging Price Buy
45313 1mg $39 Buy
45313 5mg $185 Buy
45313 10mg $293 Buy
45313 50mg $683 Buy
CS-1013670 5mg $211 Buy

1,4-Oxazepin-5(2H)-one, 4-[3-[[2-[[2-ethyl-4-(4-methyl-1-piperazinyl)phenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]propyl]tetrahydro- Chemical Properties, Uses, Production

Uses

DCC-3116 is an orally active ULK1/2 inhibitor. DCC-3116 can promote autophagy in lung cancer cells by inhibiting KRASG12C signaling, thereby inhibiting the proliferation of lung cancer cells and exerting anti-cancer effects[1].

in vivo

DCC-3116 (3 or 30 mg/kg/day for 56 days, p.o. and p.i.) alone or in combination with Sotorasib (HY-114277) can inhibit tumor growth in mouse models of NSCLC lung cancer[1].

Animal Model:mouse models of NSCLC lung cancer (adult mice were initiated between 6-8 weeks of age) [1]
Dosage:3 or 30 mg/kg/day for 56 days
Administration:p.o. and p.i
Result:Inhibited mice tumor growth and improved mice survival rate, while significantly reducing mice body weight (>20%).

IC 50

ULK1; ULK2; KRas G12C

References

[1] Ghazi PC, et al. Inhibition of ULK1/2 and KRAS G12C controls tumor growth in preclinical models of lung cancer. bioRxiv [Preprint]. 2024 Feb 8:2024.02.06.579200. DOI:10.1101/2024.02.06.579200

1,4-Oxazepin-5(2H)-one, 4-[3-[[2-[[2-ethyl-4-(4-methyl-1-piperazinyl)phenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]propyl]tetrahydro- Preparation Products And Raw materials

Raw materials

Preparation Products

1,4-Oxazepin-5(2H)-one, 4-[3-[[2-[[2-ethyl-4-(4-methyl-1-piperazinyl)phenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]propyl]tetrahydro- Suppliers

Global Suppliers ( 27)
Supplier Tel Email Country ProdList Advantage
Suzhou Chenrui Biotechnology Co. LTD 17625585511 1580084073@qq.com China 992 58
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 18149758185 sales-cpd@caerulumpharma.com China 3493 58
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4860 55
Shanghai Beckham Medical Technology Co., Ltd 13816613772 huahero21@sina.com China 2996 55
Shanghai Chaolan Chemical Technology Center QQ：65489617 13301690235 Sales@ATKchemical.com China 9699 58
Shanghai SuperLan Chemcial Technique Centre 0-2022843681 15618226720 chaolaichem@foxmail.com China 9996 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
Jining Hengqu Biotechnology Co., Ltd. 18118824509 574487903@qq.com China 2195 58
Chunchuang (Wuhan) Technology Co., Ltd 15727060112 yutianchun2007@126.com China 9867 58
Beijing Jin Ming Biotechnology Co., Ltd. 010-60605840 psaitong@jm-bio.com China 27626 58
Supplier Advantage
Suzhou Chenrui Biotechnology Co. LTD 58
ShangHai Caerulum Pharma Discovery Co., Ltd. 58
Shanghai Lollane Biological Technology Co.,Ltd. 55
Shanghai Beckham Medical Technology Co., Ltd 55
Shanghai Chaolan Chemical Technology Center 58
Shanghai SuperLan Chemcial Technique Centre 58
TargetMol Chemicals Inc. 58
Jining Hengqu Biotechnology Co., Ltd. 58
Chunchuang (Wuhan) Technology Co., Ltd 58
Beijing Jin Ming Biotechnology Co., Ltd. 58

View Latest Price from 1,4-Oxazepin-5(2H)-one, 4-[3-[[2-[[2-ethyl-4-(4-methyl-1-piperazinyl)phenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]propyl]tetrahydro- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
DCC-3116 pictures 2026-08-30 DCC-3116
2543673-19-2
 $66.00-158.00 98.55% 10g TargetMol Chemicals Inc.
  • DCC-3116 pictures
  • DCC-3116
    2543673-19-2
  • $66.00-158.00
  • 98.55%
  • TargetMol Chemicals Inc.

1,4-Oxazepin-5(2H)-one, 4-[3-[[2-[[2-ethyl-4-(4-methyl-1-piperazinyl)phenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]propyl]tetrahydro- Spectrum

1,4-Oxazepin-5(2H)-one, 4-[3-[[2-[[2-ethyl-4-(4-methyl-1-piperazinyl)phenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]propyl]tetrahydro-(2543673-19-2)1HNMR

2543673-19-2 (1,4-Oxazepin-5(2H)-one, 4-[3-[[2-[[2-ethyl-4-(4-methyl-1-piperazinyl)phenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]propyl]tetrahydro-) Related Search:

1-(5-Isoquinolinylsulfonyl)homopiperazine dihydrochloride, Fasudil dihydrochloride N-methyl-3-(1-(4-(piperazin-1-yl)phenyl)-5-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-1H-pyrazol-3-yl)propanamide 1H-Indole-2-carboxylic acid, 4,6-bis(1-methylethoxy)-, methyl ester 2,4-Pyrimidinediamine, N4-cyclopropyl-N2-(3,4-dimethoxyphenyl)-5-(trifluoromethyl)- 2-Thiophenecarboxamide, N-[(1S)-1-cyclopropyl-2,2,2-trifluoroethyl]-4-[6-(4-fluorophenyl)pyrazolo[1,5-a]pyrimidin-3-yl]-
2-Propen-1-one, 1-[(3S)-4-[(7R)-7-[6-amino-4-methyl-3-(trifluoromethyl)-2-pyridinyl]-6-chloro-8-fluoro-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]-4-quinazolinyl]-3-methyl-1-piperazinyl]-

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1,4-Oxazepin-5(2H)-one, 4-[3-[[2-[[2-ethyl-4-(4-methyl-1-piperazinyl)phenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]propyl]tetrahydro- 4-(3-((2-((2-ethyl-4-(4-methylpiperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)propyl)-1,4-oxazepan-5-one SGR-1505/DCC3116 Inlexisertib 2543673-19-2 C26H36F3N7O2