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ChemicalBook >> CAS DataBase List >>2,4-Pyrimidinediamine, N4-(8-methyl-4-cinnolinyl)-N2-[4-(4-morpholinyl)phenyl]-

2,4-Pyrimidinediamine, N4-(8-methyl-4-cinnolinyl)-N2-[4-(4-morpholinyl)phenyl]-

2,4-Pyrimidinediamine, N4-(8-methyl-4-cinnolinyl)-N2-[4-(4-morpholinyl)phenyl]- Structure
2,4-Pyrimidinediamine, N4-(8-methyl-4-cinnolinyl)-N2-[4-(4-morpholinyl)phenyl]- structure
CAS No.
2785430-89-7
Chemical Name:
2,4-Pyrimidinediamine, N4-(8-methyl-4-cinnolinyl)-N2-[4-(4-morpholinyl)phenyl]-
Synonyms
ALK5-IN-33;2,4-Pyrimidinediamine, N4-(8-methyl-4-cinnolinyl)-N2-[4-(4-morpholinyl)phenyl]-
CBNumber:
CB112199355
Molecular Formula:
C23H23N7O
Molecular Weight:
413.48
MDL Number:
MOL File:
2785430-89-7.mol
MSDS File:
SDS
Last updated:2026-07-27 17:00:41
Request For Quotation

2,4-Pyrimidinediamine, N4-(8-methyl-4-cinnolinyl)-N2-[4-(4-morpholinyl)phenyl]- Properties

Boiling point 690.5±65.0 °C(Predicted)
Density 1.341±0.06 g/cm3(Predicted)
pka 6.00±0.40(Predicted)

2,4-Pyrimidinediamine, N4-(8-methyl-4-cinnolinyl)-N2-[4-(4-morpholinyl)phenyl]- Chemical Properties, Uses, Production

Uses

ALK5-IN-33 (Compound EX-10) is a selective, orally active ALK-5 inhibitor with an IC50 ≤10 nM[1].

in vivo

ALK-IN-33 (Compound EX-10) (10-100 mg/kg; i.g.; once) reduces the phospho SMAD2 levels in a dose dependent fashion in A549 xenograft model in mice[1].

Animal Model:Female athymic nude mice, A549 xenograft model[1]
Dosage:10, 50, 75 and 100 mg/kg
Administration:Oral gavage, once
Result:Reduced the phospho SMAD2 levels (p-SMAD2) in a dose dependent fashion.

IC 50

ALK5: ≤10 nM (IC50); ALK2

References

[1] Bettina FRANZ, et al. Alk-5 inhibitors and uses thereof. Patent WO2022126133A1.

2,4-Pyrimidinediamine, N4-(8-methyl-4-cinnolinyl)-N2-[4-(4-morpholinyl)phenyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

2,4-Pyrimidinediamine, N4-(8-methyl-4-cinnolinyl)-N2-[4-(4-morpholinyl)phenyl]- Suppliers

Global Suppliers ( 2)
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29874 58
TargetMol Chemicals Inc. 13564774135 marketing@targetmol.com United States 19950 58
Supplier Advantage
TargetMol Chemicals Inc. 58
TargetMol Chemicals Inc. 58

View Latest Price from 2,4-Pyrimidinediamine, N4-(8-methyl-4-cinnolinyl)-N2-[4-(4-morpholinyl)phenyl]- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
ALK5-IN-33 pictures 2026-07-27 ALK5-IN-33
2785430-89-7
 $1520.00-2500.00 10g TargetMol Chemicals Inc.
  • ALK5-IN-33 pictures
  • ALK5-IN-33
    2785430-89-7
  • $1520.00-2500.00
  • TargetMol Chemicals Inc.

2785430-89-7 (2,4-Pyrimidinediamine, N4-(8-methyl-4-cinnolinyl)-N2-[4-(4-morpholinyl)phenyl]-) Related Search:

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2,4-Pyrimidinediamine, N4-(8-methyl-4-cinnolinyl)-N2-[4-(4-morpholinyl)phenyl]- ALK5-IN-33 2785430-89-7