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ChemicalBook >> CAS DataBase List >>5-Pyrimidinecarbonitrile, 2-[2-[(3-hydroxyphenyl)methylene]hydrazinyl]-4-(4-methoxyphenyl)-6-(4-morpholinyl)-

5-Pyrimidinecarbonitrile, 2-[2-[(3-hydroxyphenyl)methylene]hydrazinyl]-4-(4-methoxyphenyl)-6-(4-morpholinyl)-

5-Pyrimidinecarbonitrile, 2-[2-[(3-hydroxyphenyl)methylene]hydrazinyl]-4-(4-methoxyphenyl)-6-(4-morpholinyl)- Structure
5-Pyrimidinecarbonitrile, 2-[2-[(3-hydroxyphenyl)methylene]hydrazinyl]-4-(4-methoxyphenyl)-6-(4-morpholinyl)- structure
CAS No.
2458163-94-3
Chemical Name:
5-Pyrimidinecarbonitrile, 2-[2-[(3-hydroxyphenyl)methylene]hydrazinyl]-4-(4-methoxyphenyl)-6-(4-morpholinyl)-
Synonyms
PI3K-IN-34;5-Pyrimidinecarbonitrile, 2-[2-[(3-hydroxyphenyl)methylene]hydrazinyl]-4-(4-methoxyphenyl)-6-(4-morpholinyl)-
CBNumber:
CB112704887
Molecular Formula:
C23H22N6O3
Molecular Weight:
430.46
MDL Number:
MOL File:
2458163-94-3.mol
MSDS File:
SDS
Last updated:2026-05-11 16:31:51
Request For Quotation

5-Pyrimidinecarbonitrile, 2-[2-[(3-hydroxyphenyl)methylene]hydrazinyl]-4-(4-methoxyphenyl)-6-(4-morpholinyl)- Properties

Boiling point 752.6±70.0 °C(Predicted)
Density 1.32±0.1 g/cm3(Predicted)
pka 9.16±0.10(Predicted)

5-Pyrimidinecarbonitrile, 2-[2-[(3-hydroxyphenyl)methylene]hydrazinyl]-4-(4-methoxyphenyl)-6-(4-morpholinyl)- Chemical Properties, Uses, Production

Uses

PI3K-IN-34 (Compound 6g) is a highly selective PI3K inhibitor with IC50 values of 11.73, 6.09 and 11.18 μM for PI3K-α、PI3K-β and PI3K-δ , respectively. PI3K-IN-34 arrests cell cycle at G2/M phase and induces apoptosis. PI3K-IN-34 can be used in leukemia research[1].

IC 50

PI3Kα: 8.43 μM (IC50); PI3Kβ: 15.84 μM (IC50); PI3Kδ: 30.62 μM (IC50)

References

[1] Helwa AA, et al. Novel antiproliferative agents bearing morpholinopyrimidine scaffold as PI3K inhibitors and apoptosis inducers; design, synthesis and molecular docking. Bioorg Chem. 2020 Sep;102:104051. DOI:10.1016/j.bioorg.2020.104051

5-Pyrimidinecarbonitrile, 2-[2-[(3-hydroxyphenyl)methylene]hydrazinyl]-4-(4-methoxyphenyl)-6-(4-morpholinyl)- Preparation Products And Raw materials

Raw materials

Preparation Products

5-Pyrimidinecarbonitrile, 2-[2-[(3-hydroxyphenyl)methylene]hydrazinyl]-4-(4-methoxyphenyl)-6-(4-morpholinyl)- Suppliers

Global Suppliers ( 3)
Supplier Tel Email Country ProdList Advantage
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720 klq@cw-bio.com China 9780 55
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29874 58
TargetMol Chemicals Inc. 13564774135 marketing@targetmol.com United States 19950 58
Supplier Advantage
Tianjin Kailiqi Biotechnology Co., Ltd. 55
TargetMol Chemicals Inc. 58
TargetMol Chemicals Inc. 58

View Latest Price from 5-Pyrimidinecarbonitrile, 2-[2-[(3-hydroxyphenyl)methylene]hydrazinyl]-4-(4-methoxyphenyl)-6-(4-morpholinyl)- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
PI3K-IN-34 pictures 2026-05-11 PI3K-IN-34
2458163-94-3
 $1520.00-2500.00 10g TargetMol Chemicals Inc.
  • PI3K-IN-34 pictures
  • PI3K-IN-34
    2458163-94-3
  • $1520.00-2500.00
  • TargetMol Chemicals Inc.

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5-Pyrimidinecarbonitrile, 2-[2-[(3-hydroxyphenyl)methylene]hydrazinyl]-4-(4-methoxyphenyl)-6-(4-morpholinyl)- PI3K-IN-34 2458163-94-3