Triphenylphosphine oxide
- CAS No.
- 791-28-6
- Chemical Name:
- Triphenylphosphine oxide
- Synonyms
- TPO;TPPO;Ph3PO;TTPO;Triphenylphosphinoxid;triphenylphosphane oxide;Trisphenylphosphine oxide;Triphenyl phosphorus oxide;Orlistat Related CoMpound C;PP 560
- CBNumber:
- CB8296821
- Molecular Formula:
- C18H15OP
- Molecular Weight:
- 278.28
- MDL Number:
- MFCD00002080
- MOL File:
- 791-28-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Human Thrombopoietin ELISA Kit for serum, plasma, cell culture supernatants and urine | RAB0463 | 1 kit | $622 |
| Orlistat Related Compound C Pharmaceutical Secondary Standard; Certified Reference Material | PHR2544 | 50MG | $700 |
| Orlistat Related Compound C United States Pharmacopeia (USP) Reference Standard | 1478833 | 25mg | $1390 |
| Triphenylphosphine oxide analytical standard | 08902 | 100mg | $161 |
| Triphenylphosphine Oxide >98.0%(GC) | T0625 | 25g | $27 |
| More product size | |||
| Melting point | 150-157 °C(lit.) |
|---|---|
| Boiling point | 360 °C |
| bulk density | 400-450kg/m3 |
| Density | 1,212 g/cm3 |
| vapor pressure | <1 hPa (50 °C) |
| Flash point | 180 °C |
| storage temp. | Store below +30°C. |
| solubility | methanol: 25 mg/mL, clear |
| form | Crystalline Powder or Flakes |
| color | White to pink-brown |
| Specific Gravity | 1.212 |
| Water Solubility | slightly soluble |
| Hydrolytic Sensitivity | 4: no reaction with water under neutral conditions |
| BRN | 745854 |
| Henry's Law Constant | 1.9×104 mol/(m3Pa) at 25℃, Zhang et al. (2010) |
| Major Application | pharmaceutical |
| InChI | 1S/C18H15OP/c19-20(16-10-4-1-5-11-16,17-12-6-2-7-13-17)18-14-8-3-9-15-18/h1-15H |
| InChIKey | FIQMHBFVRAXMOP-UHFFFAOYSA-N |
| SMILES | O=P(c1ccccc1)(c2ccccc2)c3ccccc3 |
| LogP | 2.8 |
| CAS DataBase Reference | 791-28-6(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | Z69161FKI3 |
| NIST Chemistry Reference | (C6H5)3PO(791-28-6) |
| EPA Substance Registry System | Triphenylphosphine oxide (791-28-6) |
| UNSPSC Code | 77101502 |
| NACRES | NA.32 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H290 | |||||||||
| Precautionary statements | P234-P390 | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 22-36/37/38-52/53 | |||||||||
| Safety Statements | 26-61-36 | |||||||||
| RIDADR | 3077 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | SZ1676000 | |||||||||
| Autoignition Temperature | 590 °C | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 9 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29310095 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Aquatic Chronic 3 |
|||||||||
| Toxicity | LD50 orally in Rabbit: 685 mg/kg | |||||||||
| NFPA 704 |
|
Triphenylphosphine oxide price More Price(50)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | RAB0463 | Human Thrombopoietin ELISA Kit for serum, plasma, cell culture supernatants and urine | 1 kit | $622 | 2026-04-30 | Buy | |
| Sigma-Aldrich | PHR2544 | Orlistat Related Compound C Pharmaceutical Secondary Standard; Certified Reference Material | 791-28-6 | 50MG | $700 | 2026-04-30 | Buy |
| Sigma-Aldrich | 1478833 | Orlistat Related Compound C United States Pharmacopeia (USP) Reference Standard | 791-28-6 | 25mg | $1390 | 2026-04-30 | Buy |
| Sigma-Aldrich | 08902 | Triphenylphosphine oxide analytical standard | 791-28-6 | 100mg | $161 | 2026-04-30 | Buy |
| TCI Chemical | T0625 | Triphenylphosphine Oxide >98.0%(GC) | 791-28-6 | 25g | $27 | 2026-04-30 | Buy |
Triphenylphosphine oxide Chemical Properties,Uses,Production
Description
Triphenylphosphine oxide (TPPO) is a coordinating solvent used to activate crystallization of chemical compounds. It has been used in flame retardant applications, as an epoxy cure catalyst, and more recently, to produce nanostructures.
Chemical Properties
White solid
Uses
Triphenylphosphine oxide is a phosphine ligand used for coupling reactions, epoxidations, and Michael reactions
Uses
Triphenylphosphine oxide can be used:
As a catalyst in Appel-type chlorination reaction of acyclic primary and secondary alcohols.
As a catalyst in stereoselective poly and dibromination of α,β-unsaturated esters and β,γ-unsaturated α-ketoester compounds.
As a promotor in the diastereoselective synthesis of α-ribofuranosides through ribofuranosylation of alcohols with ribofuranosyl iodides.
Uses
Triphenylphosphine Oxide (Orlistat USP Related Compound C) is a catalyst in the conversion of aldehydes into 1,1-dichlorides. Triphenylphosphine Oxide is used as a catalyst for the synthesis of hightly functionalized α-CF3 γ-keto esters.
Definition
ChEBI: A phosphine oxide in which the substituents on phosphorus are three phenyl groups.
Synthesis Reference(s)
Tetrahedron Letters, 31, p. 5463, 1990 DOI: 10.1016/S0040-4039(00)97873-0
Flammability and Explosibility
Not classified
reaction suitability
reagent type: ligand
reaction type: Coupling Reactions
reagent type: ligand
reaction type: Epoxidations
reagent type: ligand
reaction type: Michael Reaction
Purification Methods
It crystallises from absolute EtOH and is dried in vacuo. The gold chloride complex has m 177.5-178.5o. [Addison & Sheldon J Chem Soc 2705 1956, Cox & Westheimer J Am Chem Soc 80 5441 1958, Beilstein 16 III 864, 16 1011.]
Triphenylphosphine oxide Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
1of3
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Guangzhou Xijia New Materials Co.,Ltd | +undefined13650882421 | ebswax@163.com | China | 54 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8618531123677 | faithe@yan-xi.com | China | 5853 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-86-13131129325 +8613131129325 | sales1@chuanghaibio.com | China | 5235 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 | deasea125996@gmail.com | China | 2472 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20124 | 58 |
| ShenZhen H&D Pharmaceutical Technology Co., LTD | +8618627948422 | sale@hdimpurity.com | China | 3681 | 58 |
| Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 | admin@zlchemi.com | China | 3692 | 58 |
| Moxin Chemicals | +86-17320513646 +8617320513646 | anna@molcoo.com | China | 10000 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29640 | 60 |
Related articles
- Applications of Triphenylphosphine oxide
- Triphenylphosphine oxide (often abbreviated TPPO) is the organophosphorus compound with the formula OP(C6H5)3. This colourless....
- Nov 6，2019
View Lastest Price from Triphenylphosphine oxide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-05-04 | Triphenylphosphine oxide
791-28-6
|
0.99 | RongNa Biotechnology Co.,Ltd | ||||
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2026-04-30 | Triphenylphosphine oxide
791-28-6
|
US $0.00 / KG | 1KG | 98%min | 30tons/month | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2026-03-20 | Triphenylphosphine oxide
791-28-6
|
US $0.00 / KG | 1KG | 99% | 10000KG | Guangzhou Xijia New Materials Co.,Ltd |
-
- Triphenylphosphine oxide
791-28-6
- 0.99
- RongNa Biotechnology Co.,Ltd
-
- Triphenylphosphine oxide
791-28-6
- US $0.00 / KG
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Triphenylphosphine oxide
791-28-6
- US $0.00 / KG
- 99%
- Guangzhou Xijia New Materials Co.,Ltd
