AMPK-α1β1γ1 activator 1
- CAS No.
- 1943510-86-8
- Chemical Name:
- AMPK-α1β1γ1 activator 1
- Synonyms
- AMPK-α1β1γ1 activator 1;β-D-Glucopyranuronic acid, 1-[6-chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylate]
- CBNumber:
- CB114246772
- Molecular Formula:
- C25H24ClNO9
- Molecular Weight:
- 517.91
- MDL Number:
- MOL File:
- 1943510-86-8.mol
AMPK-α1β1γ1 activator 1 Chemical Properties, Uses, Production
Uses
AMPK-α1β1γ1 activator 1 (M1) is an acyl glucuronide metabolite of Indole-3-carboxylic Acid-based AMPK activator. AMPK-α1β1γ1 activator 1 can selectively activated human β1 isoforms with an EC50 value of 38.1nM. AMPK-α1β1γ1 activator 1 can direct binding with human AMPK α1β1γ1 isoform. AMPK-α1β1γ1 activator 1 can be used for the research of diabetic nephropathy[1].
References
[1] Ryder TF, et al. Acyl Glucuronide Metabolites of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1 H-indole-3-carboxylic Acid (PF-06409577) and Related Indole-3-carboxylic Acid Derivatives are Direct Activators of Adenosine Monophosphate-Activated Protein Kinase (AMPK). J Med Chem. 2018 Aug 23;61(16):7273-7288. DOI:10.1021/acs.jmedchem.8b00807
AMPK-α1β1γ1 activator 1 Preparation Products And Raw materials
Raw materials
Preparation Products
AMPK-α1β1γ1 activator 1 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
