3-isoquinolinecarboxaldehyde
- CAS No.
- 5470-80-4
- Chemical Name:
- 3-isoquinolinecarboxaldehyde
- Synonyms
- Isoquinoline-3-carbaldehyde;3-Formylisoquinoline;3-isoquinolinecarboxaldehyde;isoquinoline-3-methylaldehyde;Isoquinoline-3-carboxaldehyde;Isoquinoline-3-carboxaldehyde 95%;3-Formylisoquinoline, 3-Formyl-2-azanaphthalene;3-isoquinolinecarboxaldehyde ISO 9001：2015 REACH;3-Isoquinolinecarboxaldehyde (6CI, 7CI, 8CI, 9CI, ACI)
- CBNumber:
- CB11458256
- Molecular Formula:
- C10H7NO
- Molecular Weight:
- 157.17
- MDL Number:
- MFCD06227437
- MOL File:
- 5470-80-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 47 °C |
|---|---|
| Boiling point | 151 °C(Press: 10 Torr) |
| Density | 1.223±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| form | solid |
| pka | 2.94±0.30(Predicted) |
| color | White |
| InChI | InChI=1S/C10H7NO/c12-7-10-5-8-3-1-2-4-9(8)6-11-10/h1-7H |
| InChIKey | XOYMAJLARWXZBA-UHFFFAOYSA-N |
| SMILES | C1C2=C(C=CC=C2)C=C(C=O)N=1 |
| FDA UNII | AG4ERY67PZ |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302+H312+H332-H315-H319-H335 |
| Precautionary statements | P271-P280 |
| HS Code | 2933499090 |
3-isoquinolinecarboxaldehyde price More Price(46)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR40275 | Isoquinoline-3-carboxaldehyde 95% | 5470-80-4 | 250mg | $30 | 2026-06-04 | Buy |
| Activate Scientific | AS1304 | Isoquinoline-3-carbaldehyde 97% | 5470-80-4 | 1g | $114 | 2026-06-04 | Buy |
| Activate Scientific | AS1304 | Isoquinoline-3-carbaldehyde 97% | 5470-80-4 | 5g | $476 | 2026-06-04 | Buy |
| Activate Scientific | AS1304 | Isoquinoline-3-carbaldehyde 97% | 5470-80-4 | 25g | $1588 | 2026-06-04 | Buy |
| Matrix Scientific | 298599 | Isoquinoline-3-carbaldehyde | 5470-80-4 | 1.00g | $71 | 2026-05-19 | Buy |
3-isoquinolinecarboxaldehyde Chemical Properties,Uses,Production
Synthesis Reference(s)
Journal of the American Chemical Society, 73, p. 688, 1951 DOI: 10.1021/ja01146a055
Synthesis
27104-73-0
5470-80-4
General procedure for the synthesis of isoquinoline-3-carbaldehyde from methyl isoquinoline-3-carboxylate: methyl isoquinoline-3-carboxylate (2.0 g, 10.7 mmol) was dissolved in toluene and the solution was cooled to -78 °C. Diisobutylaluminum hydride (1 M solution in toluene, 21.4 mL, 21.4 mmol) was slowly added to this solution using a syringe over a period of 15 minutes. Keeping the reaction mixture at -78 °C, the reaction was quenched with a mixture of ether (80 mL), acetic acid (20 mL) and water (8 mL). The mixture was then slowly warmed to room temperature and stirred overnight. The organic layer was separated and the solvent was evaporated. Purification by fast column chromatography (eluent gradient: 1:4 ethyl acetate/hexane to 1:3 ethyl acetate/hexane) afforded 1.1 g of the title compound isoquinoline-3-carbaldehyde in 65% yield.1H-NMR (CDCl3, 300 MHz) δ 10.24 (s, 1H), 9.35 (s, 1H), 8.36 (s, 1H), 8.07- 7.98 (m, 2H), 7.82-7.32 (m, 2H). MS: m/z 158 ([MH]+).
References
[1] Patent: WO2005/56550, 2005, A2. Location in patent: Page/Page column 75-76
[2] Patent: WO2005/92885, 2005, A1. Location in patent: Page/Page column 73
[3] Patent: WO2005/56562, 2005, A1. Location in patent: Page/Page column 71-72
[4] Tetrahedron Letters, 1999, vol. 40, # 6, p. 1211 - 1214
[5] Patent: US5554620, 1996, A
3-isoquinolinecarboxaldehyde Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
3-isoquinolinecarboxaldehyde Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Yancheng KangdiSen Pharmaceutical Co., Ltd. | 13812573443;18052965989 | tongbenwan22@163.com | China | 1975 | 55 |
| PharmaBlock Sciences (Nanjing), Inc. | 4000255188 13327728092 | sales@pharmablock.com | China | 9999 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| ZEROSCHEM.CO.,LTD. | 10-61256048 13810278579; | sales@zeroschem.com | China | 1399 | 59 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| China DongFan Chemical Co.,LTD | 86-0571-85151182 | China | 5681 | 66 | |
| Hangzhou Sage Chemical Co., Ltd. | +86057186818502 13588463833 | info@sagechem.com | China | 10265 | 58 |
| Shanghai Topbiochem Technology Co., Ltd | 021-58170097 | info@topbiochem.com | China | 9513 | 58 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 13913916777 | cfzhang@aikonchem.com | China | 19902 | 55 |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 18201 | 56 |
View Lastest Price from 3-isoquinolinecarboxaldehyde manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | 3-isoquinolinecarboxaldehyde
5470-80-4
|
$1.10 | 1g | 99.00% | 100 Tons | Dideu Industries Group Limited | |
 |
2021-07-13 | 3-isoquinolinecarboxaldehyde
5470-80-4
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2021-07-10 | 3-isoquinolinecarboxaldehyde
5470-80-4
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
-
- 3-isoquinolinecarboxaldehyde
5470-80-4
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 3-isoquinolinecarboxaldehyde
5470-80-4
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 3-isoquinolinecarboxaldehyde
5470-80-4
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
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