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ChemicalBook >> CAS DataBase List >>3,5-Pyridinedicarbonitrile, 2-(methyl-2-propyn-1-ylamino)-4-phenyl-6-[[3-[1-(phenylmethyl)-4-piperidinyl]propyl]amino]-

3,5-Pyridinedicarbonitrile, 2-(methyl-2-propyn-1-ylamino)-4-phenyl-6-[[3-[1-(phenylmethyl)-4-piperidinyl]propyl]amino]-

3,5-Pyridinedicarbonitrile, 2-(methyl-2-propyn-1-ylamino)-4-phenyl-6-[[3-[1-(phenylmethyl)-4-piperidinyl]propyl]amino]- Structure
3,5-Pyridinedicarbonitrile, 2-(methyl-2-propyn-1-ylamino)-4-phenyl-6-[[3-[1-(phenylmethyl)-4-piperidinyl]propyl]amino]- structure
CAS No.
1335032-28-4
Chemical Name:
3,5-Pyridinedicarbonitrile, 2-(methyl-2-propyn-1-ylamino)-4-phenyl-6-[[3-[1-(phenylmethyl)-4-piperidinyl]propyl]amino]-
Synonyms
Sigma-1 receptor antagonist 6;3,5-Pyridinedicarbonitrile, 2-(methyl-2-propyn-1-ylamino)-4-phenyl-6-[[3-[1-(phenylmethyl)-4-piperidinyl]propyl]amino]-
CBNumber:
CB114686730
Molecular Formula:
C32H34N6
Molecular Weight:
502.65
MDL Number:
MOL File:
1335032-28-4.mol
Last updated:2025-04-18 09:51:37
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3,5-Pyridinedicarbonitrile, 2-(methyl-2-propyn-1-ylamino)-4-phenyl-6-[[3-[1-(phenylmethyl)-4-piperidinyl]propyl]amino]- Properties

Boiling point 737.3±60.0 °C(predicted)
Density 1.20±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
pka 8.96±0.10(predicted)

3,5-Pyridinedicarbonitrile, 2-(methyl-2-propyn-1-ylamino)-4-phenyl-6-[[3-[1-(phenylmethyl)-4-piperidinyl]propyl]amino]- Chemical Properties, Uses, Production

Uses

Sigma-1 receptor antagonist 6 (Compound 12) is an antagonist of the Sigma-1 receptor (σ1R). Sigma-1 receptor antagonist 6 exerts a robust antiallodynic effect by antagonizing σ1R. Sigma-1 receptor antagonist 6 can be used in neuropathic pain animal models to alleviate mechanical allodynia induced by paclitaxel (HY-B0015)[1].

References

[1] Entrena JM, et al. The proof of concept of 2-{3-[N-(1-benzylpiperidin-4-yl)propyl]amino}-6-[N-methyl-N-(prop-2-yn-1-yl)amino]-4-phenylpyridine-3,5-dicarbonitrile for the therapy of neuropathic pain. Bioorg Chem. 2024 Sep;150:107537. DOI:10.1016/j.bioorg.2024.107537

3,5-Pyridinedicarbonitrile, 2-(methyl-2-propyn-1-ylamino)-4-phenyl-6-[[3-[1-(phenylmethyl)-4-piperidinyl]propyl]amino]- Preparation Products And Raw materials

Raw materials

Preparation Products

3,5-Pyridinedicarbonitrile, 2-(methyl-2-propyn-1-ylamino)-4-phenyl-6-[[3-[1-(phenylmethyl)-4-piperidinyl]propyl]amino]- Suppliers

Global Suppliers ( 1)
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29874 58
Supplier Advantage
TargetMol Chemicals Inc. 58

1335032-28-4 (3,5-Pyridinedicarbonitrile, 2-(methyl-2-propyn-1-ylamino)-4-phenyl-6-[[3-[1-(phenylmethyl)-4-piperidinyl]propyl]amino]-) Related Search:

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PB28 dihydrochloride

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3,5-Pyridinedicarbonitrile, 2-(methyl-2-propyn-1-ylamino)-4-phenyl-6-[[3-[1-(phenylmethyl)-4-piperidinyl]propyl]amino]- Sigma-1 receptor antagonist 6 1335032-28-4