ChemicalBook >> CAS DataBase List >>ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE

ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE

ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE structure

CAS No.: 161798-03-4

Chemical Name:: ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE

Synonyms: 2-(3-forMyl;Febuxostat-24;-4-isobutoxyphenyL;Febuxostat Impurity G;Febuxostat Impurity 2;Febuxostat Impurities2;Febuxostat Impurity Z18;Febuxostat Impurity Z2-2;Ethyl 2-(3-formyl-4-isobutoxyphenyl);Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiaz

CBNumber:: CB11474517

Molecular Formula:: C18H21NO4S

Molecular Weight:: 347.43

MDL Number:: MFCD13194811

MOL File:: 161798-03-4.mol

MSDS File:: SDS

Last updated:2026-07-16 18:07:46

Product description	Number	Pack Size	Price
Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate	448748	500mg	$305
Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate	448748	1g	$396
Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate 98%(HPLC)	Y0387	1g	$62
Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate 98%(HPLC)	Y0387	5g	$173
Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate 98%(HPLC)	Y0387	10g	$343
More product size

Request For Quotation

ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE Properties

Melting point	158-160°C
Boiling point	495.9±55.0 °C(Predicted)
Density	1.183
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	Chloroform (Slightly), Methanol (Slightly, Sonicated)
form	Solid
pka	1.39±0.10(Predicted)
color	Pale Yellow
InChI	InChI=1S/C18H21NO4S/c1-5-22-18(21)16-12(4)19-17(24-16)13-6-7-15(14(8-13)9-20)23-10-11(2)3/h6-9,11H,5,10H2,1-4H3
InChIKey	AIQMFFCWDAIGNV-UHFFFAOYSA-N
SMILES	S1C(C(OCC)=O)=C(C)N=C1C1=CC=C(OCC(C)C)C(C=O)=C1
CAS DataBase Reference	161798-03-4(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319
Precautionary statements	P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P
REACH Registrations	Active

ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE price More Price(50)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Usbiological	448748	Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate	161798-03-4	500mg	$305	2026-06-03	Buy
Usbiological	448748	Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate	161798-03-4	1g	$396	2026-06-03	Buy
AK Scientific	Y0387	Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate 98%(HPLC)	161798-03-4	1g	$62	2026-06-04	Buy
AK Scientific	Y0387	Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate 98%(HPLC)	161798-03-4	5g	$173	2026-06-04	Buy
AK Scientific	Y0387	Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate 98%(HPLC)	161798-03-4	10g	$343	2026-06-04	Buy

Product number	Packaging	Price	Buy
448748	500mg	$305	Buy
448748	1g	$396	Buy
Y0387	1g	$62	Buy
Y0387	5g	$173	Buy
Y0387	10g	$343	Buy

ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE Chemical Properties,Uses,Production

Uses

Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate is an impurity of Febuxostat (F229000), which is a xanthine oxidase/xanthine dehydrogenase inhibitor, used for treatment of hyperuricemia and chronic gout.

Synthesis

Preparation of Compound of formula III)[0094] A compound of formula II (10.0 gr, 34.33 mmol) was reacted with iso- butyl bromide (18.9 gr, 137.3 mmol) in the presence of potassium carbonate (19.0 gr, 137.3 mmol) and potassium iodide (2.3 gr, 13.7 mmol) in 60 ml dimethylformamide. The reaction was performed at about 70°C during 4 hours. The reaction mixture was extracted at 70°C using 300 ml ethyl acetate and 600 ml water. The separated aqueous phase was washed twice with 100 ml ethyl acetate. The combined organic phase was washed twice with 100 ml water and then concentrated to dryness. The resulting solid residue was re- crystallized from 70 ml ethyl acetate, filtered and dried under reduced pressure at about 40°C to provide a compound of formula III (8.9 gr, yield - 83percent). The Compound of formula III purity is 99.1percent (by HPLC).

References

[1] Patent: WO2011/31409, 2011, A1. Location in patent: Page/Page column 15
[2] Patent: WO2011/141933, 2011, A2. Location in patent: Page/Page column 46
[3] Patent: WO2012/131590, 2012, A1. Location in patent: Page/Page column 15; 21; 23
[4] Patent: WO2012/168948, 2012, A2. Location in patent: Page/Page column 11
[5] Patent: WO2015/18507, 2015, A2. Location in patent: Page/Page column 12

ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE Preparation Products And Raw materials

Raw materials

1-Bromo-2-methylpropane Ethyl 2-(3-Formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate Potassium iodide N,N-Dimethylformamide Potassium carbonate

Preparation Products

Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate

ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE Suppliers

Global( 342)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
HEBEI BRANT PHARMACEUTICAL CO.,LTD	+86-18713118368 18713118368	lisa@brantpharm.com	China	17	58
Ningbo Banco Chemical Technology Co., Ltd.	+86-15827200700	sales@bancochemical.com	China	487	58
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971	deasea125996@gmail.com	China	2452	58
Anhui Ruihan Technology Co., Ltd	+undefined17756083858	daisy@anhuiruihan.com	China	954	58
ShenZhen H&D Pharmaceutical Technology Co., LTD	+86-18627948422	sale@hdimpurity.com	China	3676	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29626	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	14032	58
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1796	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21531	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29766	58

Supplier	Advantage
HEBEI BRANT PHARMACEUTICAL CO.,LTD	58
Ningbo Banco Chemical Technology Co., Ltd.	58
Henan Bao Enluo International TradeCo.，LTD	58
Anhui Ruihan Technology Co., Ltd	58
ShenZhen H&D Pharmaceutical Technology Co., LTD	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58

View Lastest Price from ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE manufacturers

Update time	Product	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-08	Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate 161798-03-4	1kg	99.0%min	5MT	Hangzhou ICH Biofarm Co., Ltd
2026-08-07	Febuxostat Impurity 161798-03-4	1KG	99%min	1000kg	WUHAN FORTUNA CHEMICAL CO., LTD
2026-07-16	ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE 161798-03-4	1kg	98%	1000kgs	Shaanxi Dideu New Materials Co. Ltd

Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate
161798-03-4
$0.00
99.0%min
Hangzhou ICH Biofarm Co., Ltd

Febuxostat Impurity
161798-03-4
$0.00
99%min
WUHAN FORTUNA CHEMICAL CO., LTD

ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE
161798-03-4
$0.00
98%
Shaanxi Dideu New Materials Co. Ltd

ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE Spectrum

ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE(161798-03-4)¹HNMR

161798-03-4(ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE)Related Search:

Febuxostat Ethyl 2-(3-Cyano-4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate isopropyl 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate 2-(3-cyano-4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid

Febuxostat Impurity 6 2,2'-[4-(2-Methylpropoxy)-1,3-phenylene]bis[4-Methyl-5-thiazolecarboxylic Acid 2-[3-Carboxy-4-(2-Methylpropoxy)phenyl]-4-Methyl-5-thiazolecarboxylic Acid 2-(3-cyano-4-propoxyphenyl)-4-methylthiazole-5-carboxylic acid Febuxostat Impurity 8

4-(2-Methylpropoxy)-1,3-benzenedicarbothioaMide 4-Hydroxythiobenzamide ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate 3-Cyano-4-isobutoxybenzoic acid

FeBuxostat Impurity 33 Febuxostat impurity 37 Febuxostat-d9

1of4

Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole- Ethyl-2-(3-Formyl-4-isobutoxy phenyl)-4-methyl-1,3-thiazole-5-carboxylate Febuxostat-24 2-(3-forMyl 5-Thiazolecarboxylicacid, 2-[3-forMyl-4-(2-Methylpropoxy)phenyl]-4-Methyl-, ethyl ester ethyl-2-[3-forMyl-4-(2-Methylpropoxy)phenyl]-4-Methyl-5-thiazolecarboxylate Febuxostat Impurity 2 Febuxostat Impurity G 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate Ethyl 2-(3-formyl-4-isobutoxyphenyl) ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE 2-(3-Formyl-4-isobutoxy-phenyl)-4-methyl-thiazole-5-carboxylic acid ethyl ester 5-carboxylato-1-ethyl-2-[3-forMyl-4-(2-Methylpropoxy)phenyl]-4-Methyl-1H-1$l^{4},3-thiazol-1-yl Febuxostat Impurity Z18 2-(3-forMyl-4-isobutoxyphenyI)-4-MethyIthiazole-5-carboxylic acid ethyl ester Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiaz 2-[3-formyl-4-(2-methylpropoxy)phenyl]-4-methyl-5-Thiazolecarboxylicacid ethyl ester -4-isobutoxyphenyL Febuxostat intermediates，Ethyl 2-(3-Formyl-4-isobutoxyphenyl)- 4-Methylthiazole-5-Carboxylate Ethyl 2-(3-cyano-4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate 2- Ethyl 2-(3-Formyl-4-isobutoxyphenyl)-4-Methylthiazole-5-Carb... Febuxostat Impurities2 2 - (3-aldehyde-4-isobutyloxyphenyl) - 4-methylthiazole-5-carboxylic acid ethyl ester Ethyl 2-(3- aldehyde -4- isobutyloxyphenyl) -4- methylthiazole -5- carboxylate 5-Thiazolecarboxylic acid, 2-[3-formyl-4-(2-methylpropoxy)phenyl]-4-methyl-, ethyl ester (9CI, ACI) 2-[3-formyl-4-(2-methylpropoxy)phenyl]-4-methyl-5-Thiazolecarboxylic acid ethyl ester (9CI ACI) Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate (F4) 2-(3-formyl-4-isobutoxyphenyl)-4-methyl-1,3-thiazole-5-carboxylat Febuxostat Impurity Z2-2 Febuxostat Impurity 2 ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5- carboxylate ethyl 2-[3-formyl-4-(2-methylpropoxy)phenyl]-4-methyl-1,3-thiazole-5-carboxylate 2-(3-Formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate 98%min Ethyl 2-(3-formyl-4-isobutoxy-phenyl)-4-methylthiazol-5-carboxylate 161798-03-4 84006-10-6 1161798-03-4 Febuxostat intermediate 161798-03-4