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Ethyl 2-(3-Formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate

Ethyl 2-(3-Formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate structure

CAS No.: 161798-01-2

Chemical Name:: Ethyl 2-(3-Formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate

Synonyms: ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate;ETHYL 2-(3-FORMYL-4-HYDROXYPHENYL)-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE;Febuxostat-23;Febuxostat PI-2;-4-hydroxyphenyL;Febuxostat Impurity 1;Febuxostat Impurities1;Febuxostat Impurity Z17;Febuxostat intermediate3;Ethyl 2-(3-formyl-4-hydroxyphenyl)

CBNumber:: CB12128604

Molecular Formula:: C14H13NO4S

Molecular Weight:: 291.32

MDL Number:: MFCD13194810

MOL File:: 161798-01-2.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-07-06 17:03:36

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Ethyl 2-(3-Formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate Properties

Melting point	116 °C
Boiling point	446.7±55.0 °C(Predicted)
Density	1.335
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	6.81±0.20(Predicted)
color	Pale Yellow to Yellow
InChI	InChI=1S/C14H13NO4S/c1-3-19-14(18)12-8(2)15-13(20-12)9-4-5-11(17)10(6-9)7-16/h4-7,17H,3H2,1-2H3
InChIKey	NJRGQNNSIAFIJC-UHFFFAOYSA-N
SMILES	S1C(C(OCC)=O)=C(C)N=C1C1=CC=C(O)C(C=O)=C1
CAS DataBase Reference	161798-01-2(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H319-H315-H335
Precautionary statements	P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362
HS Code	2934100090
REACH Registrations	Active

Ethyl 2-(3-Formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate price More Price(43)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	E1394	Ethyl 2-(3-Formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate	161798-01-2	5G	$46	2026-04-30	Buy
TCI Chemical	E1394	Ethyl 2-(3-Formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate	161798-01-2	25G	$138	2026-04-30	Buy
ChemScene	CS-W022643	Ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate ≥98%	161798-01-2	10g	$7	2026-06-04	Buy
ChemScene	CS-W022643	Ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate ≥98%	161798-01-2	25g	$15	2026-06-04	Buy
ChemScene	CS-W022643	Ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate ≥98%	161798-01-2	100g	$54	2026-06-04	Buy

Product number	Packaging	Price	Buy
E1394	5G	$46	Buy
E1394	25G	$138	Buy
CS-W022643	10g	$7	Buy
CS-W022643	25g	$15	Buy
CS-W022643	100g	$54	Buy

Ethyl 2-(3-Formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate Chemical Properties, Uses, Production

Description

Ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate is a pharmaceutical intermediate used in the preparation of the xanthine oxidase inhibitor febuxostat, which is used in the treatment of hyperuricaemia and gout. It is also used in the synthesis of novel thiazolyl α-aminophosphonates.

Chemical Properties

Yellow or yellow powder

Uses

Ethyl 2-(3-Formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate is a product prepared via reaction 4-Hydroxybenzene-1-benzothiomide with ethyl-2-chloro acetoacetate. An antibacterial agent and antifungal activity against C.albicans.

Synthesis

Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate

161797-99-5

100-97-0

161798-01-2

The general procedure for the synthesis of ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate from ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate and urotropine was as follows: 120 kg of polyphosphoric acid was added to a clean and dry 200 L reactor, stirred and heated to 40-50°C. After stirring, 20 kg ( 76.0 mol) ethyl 2-(4-hydroxyphenyl)-4-methyl-5-thiazolecarboxylate and 11 kg (76.3 mol) hexamethylenetetramine (HMTA) were added sequentially. After the addition was completed, the reaction mixture was heated to 93°C for 3 hours. After completion of the reaction, the reaction solution was slowly poured into dilute aqueous glacial acetic acid solution for hydrolysis for 20 min. The reaction mixture was extracted with 300 L of ethyl acetate in three portions and the organic phases were combined. To the organic phase, 10 kg of anhydrous sodium sulfate was added for drying, and after filtration, the filtrate was concentrated under reduced pressure to obtain 210 mg of ethyl acetate solvent. To the concentrate, 100 kg of water was added and stirred to induce crystallization, followed by centrifugal separation and drying, resulting in 18.0 kg of light yellow intermediate product in 81.3% yield. The intermediate 2-(3-formyl-4-hydroxyphenyl)-4-methyl-5-thiazolecarboxylic acid ethyl ester was tested to be 99.4%, and the dicarboxylic acid impurity content was 0.008%.

References

[1] Patent: CN106366048, 2017, A. Location in patent: Paragraph 0007; 0008; 0009; 0010; 0011; 0012
[2] Patent: WO2012/14117, 2012, A1. Location in patent: Page/Page column 12
[3] Patent: WO2012/131590, 2012, A1. Location in patent: Page/Page column 15; 21-23
[4] Patent: WO2012/168948, 2012, A2. Location in patent: Page/Page column 10-11
[5] Letters in Organic Chemistry, 2015, vol. 12, # 3, p. 217 - 221

Ethyl 2-(3-Formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate synthesis

Synthesis of Ethyl 2-(3-Formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate from Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate and Hexamethylenetetramine

Ethyl 2-(3-Formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate Preparation Products And Raw materials

Raw materials

ethyl 2-broMo-3-oxobutanoate Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate N,N-Dimethylformamide Hexamethylenetetramine Acetic acid

Preparation Products

Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate

Ethyl 2-(3-Formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate Suppliers

Global Suppliers ( 417)

Supplier	Tel	Email	Country	ProdList	Advantage
Jinan Lide Pharmaceutical Technology Co., Ltd.	0531-68654990 18560195202	leadgxm@leadchem.net	China	186	58
Beijing Lianben Pharm-Chemicals Tech. Co.,Ltd	010-83386758 18810831598	sales@lianben.com	China	94	58
Changzhou Xianglong Pharmaceutical Technology Co., LTD	18661161657	sales@xianglongpharm.com	China	9998	58
Shanghai Taijilin Industrial Co., Ltd.	02150630626 17717886015	kate@tajilin.com	China	1341	58
Shanghai Jiahua Herong Biotechnology Co., Ltd	18916155073	market@trustwe.com	China	203	58
Henan Jinbak New Material Technology Co., Ltd	18737135779	1169001743@qq.com	China	106	58
Nanjing Tianyuexing Bio-tech Co.,Ltd.	吴经理15305186370 15305186370	david@chicopharm.com	China	716	58
Shanghai Newthink Biotechnology Co., Ltd.	18121861491	3847526528@qq.com	China	107	58
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
Chembest Research Laboratories Limited	021-20908456	sales@BioChemBest.com	China	5996	61

Supplier	Advantage
Jinan Lide Pharmaceutical Technology Co., Ltd.	58
Beijing Lianben Pharm-Chemicals Tech. Co.,Ltd	58
Changzhou Xianglong Pharmaceutical Technology Co., LTD	58
Shanghai Taijilin Industrial Co., Ltd.	58
Shanghai Jiahua Herong Biotechnology Co., Ltd	58
Henan Jinbak New Material Technology Co., Ltd	58
Nanjing Tianyuexing Bio-tech Co.,Ltd.	58
Shanghai Newthink Biotechnology Co., Ltd.	58
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
Chembest Research Laboratories Limited	61

View Latest Price from Ethyl 2-(3-Formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate manufacturers

Update time	Product	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-17	ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate 161798-01-2	1kg	99%min	20ton	Jinan Jianfeng Chemical Co., Ltd
2026-09-16	Ethyl 2-(3-Formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate 161798-01-2	1kg	99%		SHANGHAI T&W PHARMACEUTICAL CO., LTD.
2026-06-30	Ethyl 2-(3-Formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate 161798-01-2	1kg	99%	10000KGS	Shaanxi Dideu New Materials Co. Ltd

ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate
161798-01-2
99%min
Jinan Jianfeng Chemical Co., Ltd

Ethyl 2-(3-Formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate
161798-01-2
$0.00
99%
SHANGHAI T&W PHARMACEUTICAL CO., LTD.

Ethyl 2-(3-Formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate
161798-01-2
$0.00
99%
Shaanxi Dideu New Materials Co. Ltd

Ethyl 2-(3-Formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate Spectrum

Ethyl 2-(3-Formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate(161798-01-2)¹HNMR

161798-01-2 (Ethyl 2-(3-Formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate) Related Search:

Febuxostat Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate isopropyl 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate 2,2'-[4-(2-Methylpropoxy)-1,3-phenylene]bis[4-Methyl-5-thiazolecarboxylic Acid 5,5'-DiMethyl Ester Febuxostat Impurity 14

2-(3-cyano-4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid Febuxostat Impurity 6 2,2'-[4-(2-Methylpropoxy)-1,3-phenylene]bis[4-Methyl-5-thiazolecarboxylic Acid 2-[3-Carboxy-4-(2-Methylpropoxy)phenyl]-4-Methyl-5-thiazolecarboxylic Acid 2-(3-cyano-4-propoxyphenyl)-4-methylthiazole-5-carboxylic acid

Febuxostat Impurity 8 4-(2-Methylpropoxy)-1,3-benzenedicarbothioaMide Ethyl 2-(3-Cyano-4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate 3-Cyano-4-(2-methylpropoxy)benzenecarbothioamide Ethyl 2-(3-bromo-4-isobutoxyphenyl)- 4-methyl-5-thiazolecarboxylate

4-Hydroxythiobenzamide Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate

1of4

2-(3-Formyl-4-hydroxy-phenyl)-4-methyl-thiazole-5-carboxylic acid ethyl ester Thiazolecarboxylicacid,2-(3-forMyl-4-hydroxyphenyl)-4-Methyl-,ethylester 5-carboxylato-1-ethyl-2-(3-forMyl-4-hydroxyphenyl)-4-Methyl-1H-1$l^{4},3-thiazol-1-yl Ethyl 2-(3-forMyl-4-hydroxyphenyl)-4-Methyl-5-Thiazolecarboxylate 5-carboxylato-1-ethyl-2-(3-forMyl-4-h ETHYL 2-(3-FORMYL-4-HYDROXYPHENYL)-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE Febuxostat-23 Febuxostat intermediate3 ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl thiazo 5-Thiazolecarboxylicacid, 2-(3-forMyl-4-hydroxyphenyl)-4-Methyl-, ethyl ester 2-(3-formyl-4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate Febuxostat Impurity 1 Febuxostat PI-2 Ethyl 2-(3-formyl-4-hydroxyphenyl) 2-(3-forMyl-4-hydroxyphenyl)-4-Methyl-5-Thiazolecarboxylicacid ethyl ester Febuxostat Impurity Z17 ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl thiazole-5- -4-hydroxyphenyL ethyl-2-(3-formyl-4-hydroxyphenyl)-4-methyl thiozole-5-carboxylate Febuxostat intermediates，Ethyl 2-(3-formyl-4-hydroxyphenyl)-4- methylthiazole-5-carboxylate Ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate 2- Ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carbox... Febuxostat Impurities1 Ethyl 2-(3- aldehyde -4- hydroxyphenyl) -4- methylthiazole -5- carboxylate Ethyl 2-(3-formyl-4-hydroxypheip)-4-methylthiazole-5-carboxylate 5-Thiazolecarboxylic acid, 2-(3-formyl-4-hydroxyphenyl)-4-methyl-, ethyl ester (9CI, ACI) 2-(3-formyl-4-hydroxyphenyl)-4-methyl-5-Thiazolecarboxylic acid ethyl ester (9CI ACI) 2-(3-formyl-4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate Ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate（F3） Ethyl 2-(3-formyl-4- hydroxyphenyl)-4- 2-(3-formyl-4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylat 2- (3-aldehyde 4-hydroxyphenyl) -4-methylthiazole-5-carboxylic acid ethyl ester cEthyl 2-(3-Formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate Ehtyl 2-(3-Formyl-4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate Febuxostat Inter. (avoid the patent) ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate 161798-01-2 Febuxostat intermediate 161798-01-2