ChemicalBook >> CAS DataBase List >>Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate

Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate

Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate structure

CAS No.: 160844-75-7

Chemical Name:: Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate

Synonyms: 2-[3-cyano-4-(2-Methylpropoxy)phenyl]-4-Methyl-5-Thiazolecarboxylic acid ethyl ester;Febuxostat Ethyl Ester;Febuxostat Impurity 15/Febuxostat Ethyl Ester/Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate;Febuxostat-7;FEBUXOSTAT INT N-1;Non-Bust Impurity 23;Febuxostat Impurities3;ethyl ester of febuxostat;Febuxostat Ethyl Ester Impurity;ethyl 2-(3-cyano-4-isobutoxyphenyl)

CBNumber:: CB22129451

Molecular Formula:: C18H20N2O3S

Molecular Weight:: 344.43

MDL Number:: MFCD09833701

MOL File:: 160844-75-7.mol

MSDS File:: SDS

Last updated:2026-07-16 18:07:46

Request For Quotation

Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate Properties

Melting point	176 °C
Boiling point	497.1±55.0 °C(Predicted)
Density	1.22
storage temp.	Sealed in dry,Room Temperature
solubility	DMSO (Slightly, Heated), Methanol (Very Slightly, Heated)
form	Solid
pka	1.02±0.10(Predicted)
color	White to Off-White
InChI	InChI=1S/C18H20N2O3S/c1-5-22-18(21)16-12(4)20-17(24-16)13-6-7-15(14(8-13)9-19)23-10-11(2)3/h6-8,11H,5,10H2,1-4H3
InChIKey	OGAZOYHQFBSRMC-UHFFFAOYSA-N
SMILES	S1C(C(OCC)=O)=C(C)N=C1C1=CC=C(OCC(C)C)C(C#N)=C1
CAS DataBase Reference	160844-75-7(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319

Precautionary statements

P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362

HS Code

2934.10.2000

REACH Registrations

Active

NFPA 704

	0
2		0

Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate price More Price(47)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	E1414	Ethyl 2-(3-Cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate	160844-75-7	5G	$62	2026-04-30	Buy
TCI Chemical	E1414	Ethyl 2-(3-Cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate	160844-75-7	25G	$217	2026-04-30	Buy
Usbiological	448745	Ethyl 2-(3-Cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate	160844-75-7	250mg	$403	2026-06-03	Buy
Usbiological	448745	Ethyl 2-(3-Cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate	160844-75-7	1g	$595	2026-06-03	Buy
Biosynth	FE45493	Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate	160844-75-7	5g	$900	2026-06-04	Buy

Product number	Packaging	Price	Buy
E1414	5G	$62	Buy
E1414	25G	$217	Buy
448745	250mg	$403	Buy
448745	1g	$595	Buy
FE45493	5g	$900	Buy

Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate Chemical Properties, Uses, Production

Chemical Properties

White crystalline powder

Uses

Ethyl 2-(3-Cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate is an impurity of Febuxostat (F229000), a xanthine oxidase/xanthine dehydrogenase inhibitor. Used for treatment of hyperuricemia and chronic gout. 40-120 mg/day febuxostat was proven effective in lowering serum urate levels when administered to manage hyperuricemia in patients with gout.

Synthesis

CarboxylatePotassium carbonate (300 g, 2.17 mol) and isobutyl bromide (142.7 g, 1.041 mol) were added to a solution of ethyl-2-(3-cyano-4-hydroxyphenyl)-4-methyl-5-thiazole carboxylate (100 g, 0.347 mol) in dimethylformamide (300 mL), and the reaction mixture was heated at a temperature of about 75°C for about 8 hours. After completion of the reaction, the reaction mixture was cooled to about 40°C, and water was added. The reaction mixture was further cooled to about 0°C and stirred for about 1 hour. The solid thus obtained was filtered, washed with water, and dried to give Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate. (Yield: 11 lg, 92.9%)

Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate synthesis

Synthesis of Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate from 1-Bromo-2-methylpropane and Ethyl 2-(3-Formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate

Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate Preparation Products And Raw materials

Raw materials

5-iodo-2-isobutoxybenzonitrile Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate Ethyl 2-(3-Formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate Ethyl 2-(3-bromo-4-isobutoxyphenyl)- 4-methyl-5-thiazolecarboxylate

5-bromo-2-isobutoxy benzonitirle 3-Cyano-4-(2-methylpropoxy)benzenecarbothioamide (3-cyano-4-isobutoxyphenyl)boronic acid Febuxostat Impurity 6 Ethyl 2-bromo-4-methyl-1,3-thiazole-5-carboxylate

Ethyl 4-methyl-5-thiazoleactate Ethyl 2-(3-Cyano-4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate 5-Bromo-2-fluorobenzonitrile 1-Bromo-2-methylpropane

1of3

Preparation Products

Febuxostat

Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate Suppliers

Global Suppliers ( 427)

Supplier	Tel	Email	Country	ProdList	Advantage
Beijing Lianben Pharm-Chemicals Tech. Co.,Ltd	010-83386758 18810831598	sales@lianben.com	China	94	58
Shanghai Peiling Biological Technology Co., LTD	13127581762 13127581762	peilingchem@sina.com	China	516	58
Shanghai Boyle Chemical Co., Ltd.		sales@boylechem.com	China	2915	55
Chembest Research Laboratories Limited	021-20908456	sales@BioChemBest.com	China	5996	61
Jia Xing Isenchem Co.,Ltd	0573-85285100 18627885956	isenchem@163.com	China	9389	66
Suzhou Zehou Biotechnology Co. , Ltd.	0512-68716880 19984816880	sales@growingchem.com	China	228	64
Pure Chemistry Scientific Inc.	001-857-928-2050 or 1-888-588-9418	sales@chemreagents.com	United States	10174	62
Adamas Reagent, Ltd.	400-6009262 15618770481	yhx@titansci.com	China	14098	59
XiaoGan ShenYuan ChemPharm co,ltd	15527621225; 15527621225	1791901229@qq.com	China	6744	52
Beijing Isomersyn Technology CO;LTD	010-82954736 13391601435	sales@isomersyn.com	China	3294	57

Supplier	Advantage
Beijing Lianben Pharm-Chemicals Tech. Co.,Ltd	58
Shanghai Peiling Biological Technology Co., LTD	58
Shanghai Boyle Chemical Co., Ltd.	55
Chembest Research Laboratories Limited	61
Jia Xing Isenchem Co.,Ltd	66
Suzhou Zehou Biotechnology Co. , Ltd.	64
Pure Chemistry Scientific Inc.	62
Adamas Reagent, Ltd.	59
XiaoGan ShenYuan ChemPharm co,ltd	52
Beijing Isomersyn Technology CO;LTD	57

View Latest Price from Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-14	Febuxostat Intermediates 160844-75-7		2Kg/Bag	99% up, High Density	20 tons	Sinoway Industrial co., ltd.
2026-09-11	Febuxostat Intermediate 160844-75-7		1KG	99%min	1000kg	WUHAN FORTUNA CHEMICAL CO., LTD
2026-08-25	Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate 160844-75-7	$60.00-600.00	10kg	0.99	20tons	Zibo Hangyu Biotechnology Development Co., Ltd

Febuxostat Intermediates
160844-75-7
$0.00
99% up, High Density
Sinoway Industrial co., ltd.

Febuxostat Intermediate
160844-75-7
$0.00
99%min
WUHAN FORTUNA CHEMICAL CO., LTD

Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate
160844-75-7
$60.00-600.00
0.99
Zibo Hangyu Biotechnology Development Co., Ltd

160844-75-7 (Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate) Related Search:

Memantine Ethyl 2-(3-Cyano-4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate Febuxostat Acyl-β-D-glucuronide Febuxostat Descyano Impurity

Febuxostat Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate isopropyl 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate Febuxostat Impurity 6 2,2'-[4-(2-Methylpropoxy)-1,3-phenylene]bis[4-Methyl-5-thiazolecarboxylic Acid

2-[3-Carboxy-4-(2-Methylpropoxy)phenyl]-4-Methyl-5-thiazolecarboxylic Acid 2-(3-cyano-4-propoxyphenyl)-4-methylthiazole-5-carboxylic acid Febuxostat Impurity 8 4-(2-Methylpropoxy)-1,3-benzenedicarbothioaMide 3-Cyano-4-isobutoxybenzoic acid

FeBuxostat Impurity 33 Febuxostat impurity 37 Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate

1of4

Febuxostat Ethyl Ester Impurity Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazol Febuxostat-7 5-Thiazolecarboxylicacid, 2-[3-cyano-4-(2-Methylpropoxy)phenyl]-4-Methyl-, ethyl ester 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate Febuxostat Ethyl Ester ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate Ethyl> 2-(3-cyano-4-isobutoxyphenyl)-4-Methyl-5-th 5-carboxylato-2-[3-cyano-4-(2-Methylpropoxy)phenyl]-1-ethyl-4-Methyl-1H-1$l^{4},3-thiazol-1-yl ethyl ester of febuxostat 2-[3-cyano-4-(2-Methylpropoxy)phenyl]-4-Me 2[3-Cyano-4-(2-methyl propoxy)phenyl]4-methyl-5-thiazole carboxylic acid ethyl ester (CPT) ethyl 2-(3-cyano-4-isobutoxyphenyl) Non-Bust Impurity 23 2-(3-Cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylic Acid Ethyl Ester 2-[3-CYANO-4-(2-METHYLPROPOXY)PHENYL]-4-METHYL-5-THIAZOLECARBOXYLIC ACID ETHYL FEBUXOSTAT INT N-1 Febuxostat intermediates，Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4- methyl-5-thiazolecarboxylate 2-(4-isobutoxyphenyl)-3-carboxylate)4-methyl-1,3- thiazole-5- carboxylate acid( Febuxostat dicarboxylic acid impurity) Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarbo... Febuxostat Impurities3 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazol-5-carboxylic acid ethyl esterQ: What is 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazol-5-carboxylic acid ethyl ester Q: What is the CAS Number of 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazol-5-carboxylic acid ethyl ester Q: What is the storage condition of 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazol-5-carboxylic acid ethyl ester Febuxostat Ethyl Ester (2-[3-Cyano-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylic Acid Ethyl Ester) Ethyl 2-(3- cyano -4- isobutyloxyphenyl) -4- methylthiazole -5- carboxylate Ethyl 2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylate Ethyl 2-(3-cyno-4-isobutoxyphenyl)-4-methyl-5- thiazolecarboxylate 2-(4-ISOBUTOXYPHENYL)-3-CARBOXYLATE)4-METHYL-1,3- THIAZOLE-5- Febuxostat Ethyl Ester Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5- carboxylate 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate Febuxostat Ethyl Ester (2-[3-Cyano-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylic Acid Et ETHYL 2-[3-CYANO-4-(2-METHYLPROPOXY)PHENYL]- 4-METHYLTHIAZOLE-5-CARBOXYLATE Febuxostat Ethyl Ester: Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate 2-[3-cyano-4-(2-Methylpropoxy)phenyl]-4-Methyl-5-Thiazolecarboxylic acid ethyl ester Febuxostat Impurity 15/Febuxostat Ethyl Ester/Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate 160844-75-7 161797-01-2 Febuxostat Intermediates Febuxostat intermediate