Trans-4-(Maleimidomethyl)cyclohexanecarboxylic Acid
- CAS No.
- 69907-67-1
- Chemical Name:
- Trans-4-(Maleimidomethyl)cyclohexanecarboxylic Acid
- Synonyms
- Mal-AMCHC;5-Dioxo-2;trans-4-((2;4-Maleimidomethylcyclohexanecaroboxylic acid;trans-4-((2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl);Trans-4-(Maleimidomethyl)cyclohexanecarboxylic Acid;trans-4-(N-Maleimidomethyl)cyclohexane-1-carboxylic Acid;trans-4-(N-maleimidemethyl)cyclohexane-1-carboxylic acid;5-dihydro-1H-pyrrol-1-yl)methyl)cyclohexanecarboxylic acid;trans-4-[(2,5-dioxopyrrol-1-yl)methyl]cyclohexanecarboxylic acid
- CBNumber:
- CB11562195
- Molecular Formula:
- C12H15NO4
- Molecular Weight:
- 237.25
- MDL Number:
- MFCD11519178
- MOL File:
- 69907-67-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| trans-4-(N-Maleimidomethyl)cyclohexane-1-carboxylic Acid | M3219 | 1G | $123 |
| trans-4-(N-Maleimidomethyl)cyclohexane-1-carboxylic Acid | M3219 | 5G | $430 |
| trans-4-[(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl]cyclohexanecarboxylic acid | FM54570 | 0.005kg | $206.25 |
| trans-4-[(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl]cyclohexanecarboxylic acid | FM54570 | 0.01kg | $343.75 |
| trans-4-[(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl]cyclohexanecarboxylic acid | FM54570 | 0.025kg | $618.75 |
| More product size | |||
| Melting point | 144 °C(Solv: benzene (71-43-2)) |
|---|---|
| Boiling point | 433.6±18.0 °C(Predicted) |
| Density | 1.329 |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | soluble in Methanol |
| form | powder to crystal |
| pka | 4.80±0.10(Predicted) |
| color | White to Almost white |
| InChI | InChI=1S/C12H15NO4/c14-10-5-6-11(15)13(10)7-8-1-3-9(4-2-8)12(16)17/h5-6,8-9H,1-4,7H2,(H,16,17)/t8-,9- |
| InChIKey | LQILVUYCDHSGEU-KYZUINATSA-N |
| SMILES | [C@@H]1(C(O)=O)CC[C@@H](CN2C(=O)C=CC2=O)CC1 |
| CAS DataBase Reference | 69907-67-1 |
| FDA UNII | 7CN76JAX09 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 | |||||||||
| HS Code | 2928009090 | |||||||||
| NFPA 704 |
|
Trans-4-(Maleimidomethyl)cyclohexanecarboxylic Acid price More Price(50)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | M3219 | trans-4-(N-Maleimidomethyl)cyclohexane-1-carboxylic Acid | 69907-67-1 | 1G | $123 | 2026-04-30 | Buy |
| TCI Chemical | M3219 | trans-4-(N-Maleimidomethyl)cyclohexane-1-carboxylic Acid | 69907-67-1 | 5G | $430 | 2026-04-30 | Buy |
| Biosynth | FM54570 | trans-4-[(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl]cyclohexanecarboxylic acid | 69907-67-1 | 0.005kg | $206.25 | 2026-06-04 | Buy |
| Biosynth | FM54570 | trans-4-[(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl]cyclohexanecarboxylic acid | 69907-67-1 | 0.01kg | $343.75 | 2026-06-04 | Buy |
| Biosynth | FM54570 | trans-4-[(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl]cyclohexanecarboxylic acid | 69907-67-1 | 0.025kg | $618.75 | 2026-06-04 | Buy |
Trans-4-(Maleimidomethyl)cyclohexanecarboxylic Acid Chemical Properties,Uses,Production
Description
Trans-4-(Maleimidomethyl) cyclohexanecarboxylic Acid is a kind of carboxylate, being well known for its N-hydroxysuccinimide ester derivative (SMCC), which is a useful cross-linking reagent. SMCC is widely used for the generation of stable maleimide-activated carrier proteins, enzyme immunoconjugates and hapten carrier molecule conjugates. It can be used for the coupling of a peptide to an amino group.
Synthesis
![Cyclohexanecarboxylic acid, 4-[[(3-carboxy-1-oxo-2-propen-1-yl)amino]methyl]-, trans-](/CAS/20200515/GIF/953817-12-4.gif)
953817-12-4
69907-67-1
Step B: Maleamic acid (36.8 g, 144 mmol) and sodium acetate (13.6 g, 165 mmol) prepared in Step A were dissolved in acetic anhydride (368 mL), and the mixture was transferred to a sealed glass reaction vessel and heated to react for 3 hours at 120 °C. Upon completion of the reaction, the cooled black slurry reaction mixture was slowly poured into water (3 L), stirred thoroughly and extracted with dichloromethane. The organic layers were combined, dried with anhydrous sodium sulfate, filtered through a sintered glass funnel, and the filtrate was evaporated to dryness and dried under high vacuum to afford the target product trans-4-(maleimidomethyl)cyclohexanecarboxylic acid as a yellow solid (7.00 g, 20% yield). The product was characterized by 1H NMR (300 MHz, CDCl3): δ 6.73 (s, 2H), 3.40 (d, 2H, J = 7 Hz), 2.28 (m, 1H), 2.06 (m, 2H), 1.75 (m, 3H), 1.42 (m, 2H), 1.03 (m, 2H).
References
https://www.aatbio.com/products/smcc-4-n-maleimidomethyl-cyclohexanecarboxylic-acid-n-hydroxysuccinimide-ester-cas-64987-85-5
http://www.sigmaaldrich.com/catalog/product/sigma/m5525lang=en®ion=US
Zhang, Hongyan, et al. "Antifreeze protein detection using Rhodamine B as photoluminescence label inporous silicon." Current Applied Physics13.4(2013):736-742.
Trans-4-(Maleimidomethyl)cyclohexanecarboxylic Acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131956 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| Win-Win chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 | sales@win-winchemical.com | China | 14304 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52704 | 58 |
| Hangzhou Huarong Pharm Co., Ltd. | 571-86758373 +8613588754946 | sales@huarongpharm.com | CHINA | 3148 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19908 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +86-571-86217390; +8618058761490 | info@gihichemicals.com | China | 49962 | 58 |
| Xuzhou B&C Chemical Technology Co., Ltd | +86-400-0516-021 +8617855106283 | info@bcpharma.com | China | 2732 | 58 |
View Lastest Price from Trans-4-(Maleimidomethyl)cyclohexanecarboxylic Acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-12-31 | Trans-4-(Maleimidomethyl)cyclohexanecarboxylic Acid
69907-67-1
|
$6.60 | 1KG | 97%-99% | 1kg-1000kg | Career Henan Chemical Co |
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- Trans-4-(Maleimidomethyl)cyclohexanecarboxylic Acid
69907-67-1
- $6.60
- 97%-99%
- Career Henan Chemical Co
