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1-Amino-4-methylpiperazine

1-Amino-4-methylpiperazine Structure
1-Amino-4-methylpiperazine structure
CAS No.
6928-85-4
Chemical Name:
1-Amino-4-methylpiperazine
Synonyms
4-methylpiperazin-1-amine;AMPRZ;1A4MP;1-Amino-4-Methyl;TIMTEC-BB SBB004299;AMINOMETHYLPIPERAZINE;LABOTEST-BB LT00005082;1-piperazinylmethanamine;1-METHYL-4-AMINOPIERAZINE;1-AMINO-4-METHYLPIERAZINE
CBNumber:
CB1177970
Molecular Formula:
C5H13N3
Molecular Weight:
115.18
MDL Number:
MFCD00006154
MOL File:
6928-85-4.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-27 23:33:19
Request For Quotation

1-Amino-4-methylpiperazine Properties

Boiling point 172-175 °C (lit.)
Density 0.957 g/mL at 25 °C (lit.)
vapor pressure 1.29hPa at 25℃
refractive index 1.4835-1.4855
Flash point 62 °C
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility water: soluble
form Viscous Solution
pka 7+-.0.42(Predicted)
color Clear
Water Solubility miscible
Sensitive Air & Light Sensitive
BRN 103334
InChI 1S/C5H13N3/c1-7-2-4-8(6)5-3-7/h2-6H2,1H3
InChIKey RJWLLQWLBMJCFD-UHFFFAOYSA-N
SMILES CN1CCN(N)CC1
LogP -1.61 at 25℃
CAS DataBase Reference 6928-85-4(CAS DataBase Reference)
FDA UNII J5GBT1LFT2
NIST Chemistry Reference 1-Amino-4-methylpiperazine(6928-85-4)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs Respiratory system
PPE Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes  Xi,Xn
Risk Statements  36/37/38-20/21/22
Safety Statements  24/25-36-26
RIDADR  2733
WGK Germany  3
HazardClass  3
PackingGroup  III
HS Code  29335995
Storage Class 10 - Combustible liquids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
REACH Registrations Active
NFPA 704
2
2 1

1-Amino-4-methylpiperazine price More Price(53)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 255688 1-Amino-4-methylpiperazine 97% 6928-85-4 25g $70.9 2026-04-30 Buy
TCI Chemical A1192 1-Amino-4-methylpiperazine >98.0%(GC)(T) 6928-85-4 25mL $69 2026-04-30 Buy
TCI Chemical A1192 1-Amino-4-methylpiperazine >98.0%(GC)(T) 6928-85-4 500mL $1028 2026-04-30 Buy
TRC TRC-A613435-25G 1-Amino-4-methylpiperazine (>90%) 6928-85-4 25g $68 2026-06-03 Buy
TRC TRC-A613435-100G 1-Amino-4-methylpiperazine (>90%) 6928-85-4 100g $151 2026-06-03 Buy
Product number Packaging Price Buy
255688 25g $70.9 Buy
A1192 25mL $69 Buy
A1192 500mL $1028 Buy
TRC-A613435-25G 25g $68 Buy
TRC-A613435-100G 100g $151 Buy

1-Amino-4-methylpiperazine Chemical Properties,Uses,Production

Chemical Properties

clear colorless to light yellow liquid

Uses

1-Amino-4-methylpiperazine has been used:
in synthesis of pyrazolo-pyrazine, -pyridine derivatives and 2-[(4-methylpiperazin-1-yl)iminomethyl]phenol
as a solvating and stabilizing agent in the preparation of uniform Ag nanoparticles (<10nm)
synthesis of N-(4-Fluorobenzylidene)-4-methylpiperazin1-amine
synthesis of 4-Methyl-N-(3,4,5-trimethoxybenzylidene) piperazin-1-amine
synthesis of N-(3,4-Dichlorobenzylidene)-4- methylpiperazin-1-amine
synthesis of N-(4-(Diethylamino)benzylidene)-4- methylpiperazin-1-amine
synthesis of N-(2,5-Dimethoxybenzylidene)-4- methylpiperazin-1-amine
synthesis of 4-Methyl-N-((5-nitrofuran-2- yl)methylene)piperazin-1-amine

Application

1-Amino-4-methylpiperazine, a derivative of piperazine, is used widely as an intermediate in the synthesis of pharmaceutical agents. It is an important intermediate for Rifampicin. Rifampicin , known as rifampin, is an antibiotic used to treat a several kinds of bacterial infections such as tuberculosis, leprosy and Legionnare's disease.

Preparation

1-Amino-4-methylpiperazine is obtained from piperazine hexahydrate through the steps of methylation, hydrolysis, nitrosation and reduction.
1-Amino-4-methylpiperazine is synthesized by chlorination of methyl(diethanol)amine (I) and subsequent cyclization of the di(chloroethyl)amine (II) obtained in aqueous hydrazine.

Flammability and Explosibility

Not classified

1-Amino-4-methylpiperazine synthesis

16339-07-4
109-01-3
6928-85-4
Synthesis of 1-Amino-4-methylpiperazine from 1-methyl-4-nitrosopiperazine

1-Amino-4-methylpiperazine Preparation Products And Raw materials

Raw materials

ZINC Piperazine hexahydrate 1-Methylpiperazine Water 1-Piperazinecarbaldehyde

Preparation Products

1-Amino-4-methylpiperazine Suppliers

Global( 359)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Qiao Chemical Science Co., Ltd 021-58892003 info@qiaochem.com China 6065 65
Suzhou ARTK Medchem Co., Ltd. 18168183658 sales1@artkmedchem.com China 782 58
TaizhouDaozhiTechCo.,Ltd +86-15958626787 15958626787@163.com China 20 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
INTATRADE GmbH +49 3493/605464 sales@intatrade.de Germany 3563 66
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Supplier Advantage
Shanghai Qiao Chemical Science Co., Ltd 65
Suzhou ARTK Medchem Co., Ltd. 58
TaizhouDaozhiTechCo.,Ltd 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
INTATRADE GmbH 66
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61
Capot Chemical Co., Ltd 66

View Lastest Price from 1-Amino-4-methylpiperazine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-Methyl-1-piperazinamine pictures 2026-09-02 4-Methyl-1-piperazinamine
6928-85-4
 $3.00-10.00 1kg 99% Henan Fengda Chemical Co., Ltd
1-Amino-4-methylpiperazine pictures 2026-06-30 1-Amino-4-methylpiperazine
6928-85-4
 1kg 99% 10000KGS Shaanxi Dideu New Materials Co. Ltd
1-Amino-4-methylpiperazine pictures 2026-05-15 1-Amino-4-methylpiperazine
6928-85-4
 $1.50 1g 99.0% Min 100 Tons Shaanxi Didu New Materials Co. Ltd

1-Amino-4-methylpiperazine Spectrum

1-Amino-4-methylpiperazine(6928-85-4)MS1-Amino-4-methylpiperazine(6928-85-4)1HNMR1-Amino-4-methylpiperazine(6928-85-4)13CNMR1-Amino-4-methylpiperazine(6928-85-4)IR11-Amino-4-methylpiperazine(6928-85-4)Raman

6928-85-4(1-Amino-4-methylpiperazine)Related Search:

Butylamine hydrochloride 1-Aminononadecane 1-Aminoheptadecane 4-[(2-Methoxyethyl)amino]-1-methylpiperazine 1-Amino-4-methylpiperazine dihydrochloride monohydrate
Rifampicin

1of2

LABOTEST-BB LT00005082 1-METHYL-4-AMINOPIERAZINE 1-METHYL-4-AMINOPIPERAZINE 1-AMINO-4-METHYLPIERAZINE 1-AMINO-4-METHYLPIPERAZINE 4-AMINO-1-METHYLPIPERAZINE 4-methylpiperazin-1-ylamine AMPRZ TIMTEC-BB SBB004299 N-METHYL-N-AMINOPIPERAZINE 1-Piperazinamine, 4-methyl- 1-AMino-4-Methylpiperazine, 99% 25GR 1-Amino-4-methylpiperazine 97% Amino methyl piperazine Alias 4-Methyl-1-piperazinamine AMINOMETHYLPIPERAZINE 1-Amino-4-Methyl 1-Amino-4-methylpiperazine ,98% 1-Methylpiperazine-4-amine 4-Methyl-1-aminopiperazine 1-Amino-4-methylpiperazine,99% 1-METHYL-4-AMINOPIPERAZINE(1-AMINO-4-METHYLPIPERAZINE) 1-piperazinylmethanamine 1-Amino-4-methylpiperazine > 1-Amino-4-methylpiperazine ISO 9001：2015 REACH 1-Amino-4-methylpiperazine (>90%) 6928-85-4 1-Amino-4-methylpiperazine 1-Amino 4-Methyl Piperazine (AMP) 1A4MP 4-methylpiperazin-1-amine 6928-85-4 6298-85-4 C5H13N3 C5H13N2 Piperazines Heterocyclic Building Blocks Building Blocks Building Blocks Heterocyclic Building Blocks Piperazines Piperaizine Piperazine derivates