8-(4-Chlorophenylthio)-2',O-methyladenosine 3',5'-cyclic monophosphate sodium salt
- CAS No.
- 510774-50-2
- Chemical Name:
- 8-(4-Chlorophenylthio)-2',O-methyladenosine 3',5'-cyclic monophosphate sodium salt
- Synonyms
- 8-CPT-2'-O-ME CAMP NA;CAMP, 8-CPT-2'-O-ME, NA;-O-methyladenosine3’8CPT-2ME-CAMP, SODIUM SALT;-cyclicMonophosphateSodiumSalt;8-(4-Chlorophenylthio)-2’8-PCPT-2''-O-ME-CAMP SODIUM SALT;8-[(4-Chlorophenyl)thio]-2'-O-methyladenosine cyclic 3',5'-(hydrogen phosphate);8-(4-Chlorophenylthio)-2'-O-methyladenosine 3',5'-cyclic monophosphate sodium salt;8-(4-Chlorophenylthio)-2',O-methyladenosine 3',5'-cyclic monophosphate sodium salt
- CBNumber:
- CB1194975
- Molecular Formula:
- C17H17ClN5O6PS
- Molecular Weight:
- 485.84
- MDL Number:
- MFCD04974491
- MOL File:
- Mol file
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 748.9±70.0 °C(Predicted) |
|---|---|
| Density | 1.95±0.1 g/cm3(Predicted) |
| storage temp. | Desiccate at -20°C |
| solubility | water: 10 mg/mL |
| form | White to off-white crystalline powder. |
| pka | 0.92±0.60(Predicted) |
| Water Solubility | water: 10mg/mL |
| UNSPSC Code | 12352208 |
8-(4-Chlorophenylthio)-2',O-methyladenosine 3',5'-cyclic monophosphate sodium salt price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 295627 | 8-(4-Chlorophenylthio)-2'-O-methyladenosine 3',5'-cyclic monophosphate sodium salt Asreported | 510774-50-2 | 1mg | $496 | 2026-06-03 | Buy |
| Usbiological | 295627 | 8-(4-Chlorophenylthio)-2'-O-methyladenosine 3',5'-cyclic monophosphate sodium salt Asreported | 510774-50-2 | 2mg | $672 | 2026-06-03 | Buy |
| Usbiological | 295627 | 8-(4-Chlorophenylthio)-2'-O-methyladenosine 3',5'-cyclic monophosphate sodium salt Asreported | 510774-50-2 | 5mg | $1133 | 2026-06-03 | Buy |
| Usbiological | 295627 | 8-(4-Chlorophenylthio)-2'-O-methyladenosine 3',5'-cyclic monophosphate sodium salt Asreported | 510774-50-2 | 10mg | $1798 | 2026-06-03 | Buy |
| Usbiological | 295627 | 8-(4-Chlorophenylthio)-2'-O-methyladenosine 3',5'-cyclic monophosphate sodium salt Asreported | 510774-50-2 | 25mg | $3319 | 2026-06-03 | Buy |
8-(4-Chlorophenylthio)-2',O-methyladenosine 3',5'-cyclic monophosphate sodium salt Chemical Properties, Uses, Production
Uses
8-(4-Chlorophenylthio)-2''-O-methyladenosine 3'',5''-cyclic Monophosphate sodium salt is an activator of the Epac cAMP receptor. It can be used in biological study of interaction between TCL1 and Epac1 in activation of Akt kinases in plasma membranes and nuclei of 8-CPT-2-O-Me-cAMP-stimulated macrophages
Biological Activity
Selective activator of Epac, the cAMP-sensitive guanine nucleotide-exchange factor for Rap1 and Rap2. Activates Epac1 (EC 50 = 2.2 mM), but not PKA (EC 50 > 10 mM). Stimulates Epac-mediated Ca 2+ -mediated Ca 2+ release in pancreatic b-cells in vitro .
in vivo
8-CPT-2'-O-Me-cAMP (2.05μM; 1 μL; intravitreal injection) inhibits development of choroidal neovascular lesions in a laser-injury model[1].
| Animal Model: | Wild type (WT) C57/Bl6 mice (choroidal neovascularization (CNV) model) [1] |
| Dosage: | 2.05μM; 1 μL |
| Administration: | Intravitreal injection |
| Result: | Induced a slight increase in F-actin localization to the cell periphery, and reorganized cell junctions to a more linear shape, dose-dependent decreased in CNV volume, increased Rap1 activity in isolated RPE/choroids. |
8-(4-Chlorophenylthio)-2',O-methyladenosine 3',5'-cyclic monophosphate sodium salt Preparation Products And Raw materials
Raw materials
Preparation Products
8-(4-Chlorophenylthio)-2',O-methyladenosine 3',5'-cyclic monophosphate sodium salt Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8435 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| NewCan Biotech Limited | +86-571-86912261 19975279805 | sales@newcanbio.com | China | 9984 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44871 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| Shanghai meikai technology co., ltd | 021-68689288 15300790979 | info@mkbio.com.cn | China | 9988 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49709 | 58 |
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