Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>3,11-Dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepine 5,5-dioxide

3,11-Dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepine 5,5-dioxide

3,11-Dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepine 5,5-dioxide Structure
3,11-Dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepine 5,5-dioxide structure
CAS No.
26638-66-4
Chemical Name:
3,11-Dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepine 5,5-dioxide
Synonyms
Tianeptine intermediates;Tianeptine sodium intermediates;Tianeptine InterMediate (the ninth step);Tianeptine Thiazepinyl Chloride IMpurity;5,8-Dichloro-11-Methyldibenzo[c,f]thiazepine 10,10-dioxide;5,8-DICHLORO-10-DIOXO-11-METHYL-DIBENZO[C,F][1,2]THIAZEPINE;3,11-dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepi...;3,11-DICHLORO-6,11-6-METHYLDIBENZO[C,F][1,2]THIAZEPINE5,5-DIOXIDE;3,11-dichloro-6-methyl-11H-benzo[c][2,1]benzothiazepine 5,5-dioxide;3,11-Dichloro-6,11-dihydro-6-methyl-5,5-dioxodibenzo[c,f][1,2]thiazepine
CBNumber:
CB1201158
Molecular Formula:
C14H11Cl2NO2S
Molecular Weight:
328.21
MDL Number:
MFCD09743977
MOL File:
26638-66-4.mol
MSDS File:
SDS
Last updated:2026-05-27 23:13:59
Request For Quotation

3,11-Dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepine 5,5-dioxide Properties

Melting point >233oC (dec.)
Boiling point 445.3±55.0 °C(Predicted)
Density 1.54±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO (Slightly)
form Solid
pka -4.11±0.40(Predicted)
color White
InChI InChI=1S/C14H11Cl2NO2S/c1-17-12-5-3-2-4-10(12)14(16)11-7-6-9(15)8-13(11)20(17,18)19/h2-8,14H,1H3
InChIKey FHICZIHQHGRZLE-UHFFFAOYSA-N
SMILES S1(=O)(=O)C2=CC(Cl)=CC=C2C(Cl)C2=CC=CC=C2N1C

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)Exclamation Mark (GHS07)
GHS05,GHS07
Signal word  Danger
Hazard statements  H302-H314
Precautionary statements  P260-P264-P270-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P405-P501
REACH Registrations Active

3,11-Dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepine 5,5-dioxide price More Price(31)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Usbiological 288650 rac 3,11-dichloro-6,11-dihydro-6-methyl-dibenzo[c,f][1,2]thiazepine 5,5-dioxide 26638-66-4 10mg $446 2026-06-03 Buy
Usbiological 288650 rac 3,11-dichloro-6,11-dihydro-6-methyl-dibenzo[c,f][1,2]thiazepine 5,5-dioxide 26638-66-4 25mg $679 2026-06-03 Buy
Usbiological 288650 rac 3,11-dichloro-6,11-dihydro-6-methyl-dibenzo[c,f][1,2]thiazepine 5,5-dioxide 26638-66-4 50mg $1044 2026-06-03 Buy
Usbiological 288650 rac 3,11-dichloro-6,11-dihydro-6-methyl-dibenzo[c,f][1,2]thiazepine 5,5-dioxide 26638-66-4 100mg $1649 2026-06-03 Buy
Usbiological 288650 rac 3,11-dichloro-6,11-dihydro-6-methyl-dibenzo[c,f][1,2]thiazepine 5,5-dioxide 26638-66-4 250mg $2697 2026-06-03 Buy
Product number Packaging Price Buy
288650 10mg $446 Buy
288650 25mg $679 Buy
288650 50mg $1044 Buy
288650 100mg $1649 Buy
288650 250mg $2697 Buy

3,11-Dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepine 5,5-dioxide Chemical Properties, Uses, Production

Chemical Properties

Off-White Solid

Uses

Intermediate in the preparation of Tianeptine and respective metabolites

Synthesis

3-Chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-ol 5,5-dioxide

26723-60-4

3,11-Dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepine 5,5-dioxide

26638-66-4

General procedure for the synthesis of 3,11-dichloro-6,11-dihydro-6-methyl-dibenzo[c,f][1,2]thiazepin-11-ol 5,5-dioxide from 3-chloro-6,11-dihydro-6-methyl-dibenzo[c,f][1,2]thiazepin 5,5-dioxide: the compound of formula III (58.0 g) was suspended in dichloromethane ( 600 ml) and cooled to 0-10°C. Hydrogen chloride gas was passed into the suspension at 0-10°C and the reaction was kept for 2-4 hours. Upon completion of the reaction, the precipitate was collected by filtration and the resulting solid was dried to constant weight to afford the target product 3,11-dichloro-6,11-dihydro-6-methyl-dibenzo[c,f][1,2]thiazepine 5,5-dioxide in 90-95% yield.

References

[1] Patent: WO2010/70667, 2010, A2. Location in patent: Page/Page column 5
[2] Journal of Medicinal Chemistry, 1992, vol. 35, # 13, p. 2481 - 2496

3,11-Dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepine 5,5-dioxide Preparation Products And Raw materials

Raw materials

3-Chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-ol 5,5-dioxide Dichloromethane Hydrochloric acid

Preparation Products

3,11-Dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepine 5,5-dioxide Suppliers

Global Suppliers ( 169)
Supplier Tel Email Country ProdList Advantage
Ningbo Dingsheng New Material Co. , Ltd. 0574-27961868 jianghuanhuan@lumilan.cn China 10 58
Shaanxi DIDU pharmaceutical and Chemical Co., Ltd 029-029-029-81148696 18161915376 1027@dideu.com China 9989 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Shijiazhuang Sdyano Fine Chemical Co., Ltd. 0311-89250318 13582355795 master@sjzsdyn.com China 2776 65
JinYan Chemicals(ShangHai) Co.,Ltd. 13817811078 sales@jingyan-chemical.com China 9963 60
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Chemsky（shanghai）International Co.,Ltd. 021-50135380 shchemsky@sina.com China 32273 50
Beijing Isomersyn Technology CO;LTD 010-82954736 13391601435 sales@isomersyn.com China 3294 57
Shanghai Ennopharm Co., Ltd. +86 (21) 6435-5022 China 4263 65
Tianjin heowns Biochemical Technology Co., Ltd. 400 638 7771 sales@heowns.com China 14412 57
Supplier Advantage
Ningbo Dingsheng New Material Co. , Ltd. 58
Shaanxi DIDU pharmaceutical and Chemical Co., Ltd 58
J & K SCIENTIFIC LTD. 76
Shijiazhuang Sdyano Fine Chemical Co., Ltd. 65
JinYan Chemicals(ShangHai) Co.,Ltd. 60
Shanghai Hanhong Scientific Co.,Ltd. 64
Chemsky（shanghai）International Co.,Ltd. 50
Beijing Isomersyn Technology CO;LTD 57
Shanghai Ennopharm Co., Ltd. 65
Tianjin heowns Biochemical Technology Co., Ltd. 57

View Latest Price from 3,11-Dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepine 5,5-dioxide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3,11-Dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepine 5,5-dioxide pictures 2026-09-20 3,11-Dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepine 5,5-dioxide
26638-66-4
 1kg 99%min 5000kg Jinan Jianfeng Chemical Co., Ltd
Tianeptine pictures 2026-05-28 Tianeptine
26638-66-4
 $10.00 1KG 98% 10 ton Hebei Chuanghai Biotechnology Co,.LTD
3,11-dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepine 5,5-dioxide pictures 2021-07-13 3,11-dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepine 5,5-dioxide
26638-66-4
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd
  • Tianeptine pictures
  • Tianeptine
    26638-66-4
  • $10.00
  • 98%
  • Hebei Chuanghai Biotechnology Co,.LTD

26638-66-4 (3,11-Dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepine 5,5-dioxide) Related Search:

Dihydromyrcenol 2-Chloro-5-chloromethylpyridine Tetramethylammonium hydroxide pentahydrate Zirconium dioxide Dichloromethylphenylsilane
Dichlorodimethylsilane Sulfurous Acid Chlorine dioxide Quartz Carbon dioxide
Rutile Thiophanate-methyl Tianeptine sodium salt Tianeptine Methyl Ester sulfur dioxide
3,11-Dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepine 5,5-dioxide SilicaDioxide

1of4

Dibenzo[c,f][1,2]thiazepine,3,11-dichloro-6,11-dihydro-6-methyl-,5,5-dioxide 3,11-DICHLORO-6,11-6-METHYLDIBENZO[C,F][1,2]THIAZEPINE5,5-DIOXIDE 5,8-DICHLORO-10-DIOXO-11-METHYL-DIBENZO[C,F][1,2]THIAZEPINE DIBENZO[C,F][1,2]THIAZEPINE,3,11-DICHLORO-6,11-DIHYDRO-6-METHYL-,5,5-DIOXIDE (8CI,9CI) 3-Chloro-6,11-dihydro-6-methyl-11-chlorodibenzo[c,f][1,2]thiazepine 5,5-dioxide 3,11-Dichloro-6,11-dihydro-6-methyl-5,5-dioxodibenzo[c,f][1,2]thiazepine rac 3,11-Dichloro-6,11-dihydro-6-methyl-dibenzo[c,f][1,2]thiazepine 5,5-Dioxide Tianeptine InterMediate (the ninth step) 3,11-DICHLORO-6,11-DIHYDRO-5,5-DIOXO-11-HYDROXY-6-METHYLDIBENZO[C,F][1,2]THIAZEPINE 3,11-dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepine 5,5-dioxide Tianeptine intermediates 5,8-Dichloro-11-Methyldibenzo[c,f]thiazepine 10,10-dioxide Tianeptine Thiazepinyl Chloride IMpurity 3,11-Dichloro-6-Methyl-6,11-dihydrodibenzo[c,f][1,2]thiazepine 5,5-dioxide 3,11-dichloro-6-methyl-11H-benzo[c][2,1]benzothiazepine 5,5-dioxide 11-Dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepine 5,5-dioxide 3,11-Dichloro-6,11-dihydro-6-methyld26638-66-4ibenzo[c,f][1,2]thiazepine 5,5-dioxide Tianeptine sodium intermediates 3,11-dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepi... 3,11-Dichloro-6,11-dihydro-6-methyl-dibenzo [c, f] [1,2] thiodiazepine 5,5-dioxide 3,11-Dichloro-6,11-dihydro-6-methyl-dibenzo[c,f][1,2]thiazepin 5,5-dioxide 26638-66-4 Intermediate Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals 26638-66-4