1,2,3,4,8,9,10,11-Octahydro[1,4]diazepino[6,7,1-jk]carbazole hydrochloride
![1,2,3,4,8,9,10,11-Octahydro[1,4]diazepino[6,7,1-jk]carbazole hydrochloride Structure](CAS/GIF/57756-45-3.gif)
- CAS No.
- 57756-45-3
- Chemical Name:
- 1,2,3,4,8,9,10,11-Octahydro[1,4]diazepino[6,7,1-jk]carbazole hydrochloride
- Synonyms
- WAY 629 hydrochlorid;WAY 629 HYDROCHLORIDE;4,5,6,7,9,10,11,12-Octahydro[1,4]diazepino[6,7,1-jk]carbazole;[1,4]Diazepino[6,7,1-jk]carbazole, 4,5,6,7,9,10,11,12-octahydro-;1,2,3,4,8,9,10,11-Octahydro[1,4]diazepino[6,7,1-jk]carbazole hydrochloride
- CBNumber:
- CB1212002
- Molecular Formula:
- C15H18N2
- Molecular Weight:
- 226.32
- MDL Number:
- MFCD06798323
- MOL File:
- 57756-45-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 114-115℃ |
|---|---|
| storage temp. | Desiccate at +4°C |
| FDA UNII | V59TZ3ACG6 |
1,2,3,4,8,9,10,11-Octahydro[1,4]diazepino[6,7,1-jk]carbazole hydrochloride Chemical Properties, Uses, Production
Uses
WAY 629 is a selective SR-2C agonist. Potent and efficacious 5-HT2C receptor agonists.
Definition
ChEBI: LSM-3233 is a member of carbazoles.
Biological Activity
Selective 5-HT 2C agonist. K i values are 56, 2350, 1575 and 815 nM for human recombinant 5-HT 2C , 5-HT 2A , 5-HT 6 and 5-HT 7 receptors respectively. Stimulates intracellular Ca 2+ mobilization in CHO cells expressing human 5-HT 2C receptors (EC 50 = 72 nM). Reduces food intake in rats.
in vivo
WAY 629 (30 mg/kg; i.p.) decreases feeding behavior in rats[1].
WAY 629 (21 mg/kg; i.p.) decreases the expression of NPY mRNA in mice brains[2].
| Animal Model: | WT mice[2] |
| Dosage: | 21 mg/kg |
| Administration: | I.p. |
| Result: | Decreased the expression of NPY mRNA. |
IC 50
5-HT2C Receptor: 426 nM (EC50); 5-HT2A Receptor: 260000 nM (EC50)
1,2,3,4,8,9,10,11-Octahydro[1,4]diazepino[6,7,1-jk]carbazole hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
1,2,3,4,8,9,10,11-Octahydro[1,4]diazepino[6,7,1-jk]carbazole hydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Shanghai Hekang Biotechnology Co., Ltd. | 17721021104 18939837085 | 2880152141@qq.com | China | 1840 | 55 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8435 | 60 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44871 | 58 |
| Shanghai Universal Biotech Co.,Ltd | 15921930842 15921930842 | yh-wang@univ-bio.com | China | 25030 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Shaanxi Didu Pharmaceutical Co., Ltd. | 029-81124775 17791530730 | 1079@dideu.com | China | 10000 | 58 |
| DAYANG CHEM (HANGZHOU) CO.,LTD | +86-88938639 +86-17705817739 | info@dycnchem.com | China | 53589 | 58 |
| TargetMol Chemicals Inc. | 13564774135 | marketing@targetmol.com | United States | 19950 | 58 |
