Amsacrine
- CAS No.
- 51264-14-3
- Chemical Name:
- Amsacrine
- Synonyms
- AMSA;CI-880;m-AMSA;C01553;Amekrin;Amsidyl;Amsakrin;AMSIDINE;Lamasine;SN 11841
- CBNumber:
- CB1236394
- Molecular Formula:
- C21H19N3O3S
- Molecular Weight:
- 393.46
- MDL Number:
- MFCD00242748
- MOL File:
- 51264-14-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 230-240 °C |
|---|---|
| Boiling point | 563.0±60.0 °C(Predicted) |
| Density | 1.2205 (rough estimate) |
| refractive index | 1.6740 (estimate) |
| storage temp. | 2-8°C(protect from light) |
| solubility | Soluble in DMSO |
| form | Powder |
| pka | 8.55±0.10(Predicted) |
| color | Orange to red |
| CAS DataBase Reference | 51264-14-3 |
| NCI Dictionary of Cancer Terms | amsacrine |
| FDA UNII | 00DPD30SOY |
| NCI Drug Dictionary | amsacrine |
| ATC code | L01XX01 |
| Proposition 65 List | Amsacrine |
| IARC | 2B (Vol. 76) 2000 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H227 |
| Precautionary statements | P501-P210-P264-P280-P302+P352-P370+P378-P337+P313-P305+P351+P338-P362+P364-P332+P313-P403+P235 |
| RIDADR | 3249 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| Hazardous Substances Data | 51264-14-3(Hazardous Substances Data) |
| Toxicity | LD50 in male, female CDF1 mice: 810 mg/m2; 729 mg/m2 orally (Pavkov) |
Amsacrine price More Price(43)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-1942 | Amsacrine 99.91% | 51264-14-3 | 5mg | $87 | 2026-06-04 | Buy |
| ChemScene | CS-1942 | Amsacrine 99.91% | 51264-14-3 | 10mg | $135 | 2026-06-04 | Buy |
| ChemScene | CS-1942 | Amsacrine 99.91% | 51264-14-3 | 25mg | $271 | 2026-06-04 | Buy |
| ChemScene | CS-1942 | Amsacrine 99.91% | 51264-14-3 | 50mg | $433 | 2026-06-04 | Buy |
| ChemScene | CS-1942 | Amsacrine 99.91% | 51264-14-3 | 100mg | $693 | 2026-06-04 | Buy |
Amsacrine Chemical Properties, Uses, Production
Description
Amsacrine is a cytostatic reported to be active against adult lymphoblastic leukemia which has failed primary treatment or become resistant. Its clinical use, however, is associated with significant neuro-, gastro- and hepatotoxicity.
Chemical Properties
Acute toxicity LD50 male mice, female mice (mg/m2): 810, 729 oral. Amsacrine Hydrochloride (Amsacrine Hydrochloride): C2Lh19N3O3SHCl. crystalline, melting point 197-199°C. Acute toxicity LD50 mice (mg/kg): about 60 intraperitoneally. Amsacrine Methanesulfonate (Amsacrine Methanesulfonate): C21H19N3O3SCH3SO3H. crystallization, melting point 292-293 ℃. Acute toxicity LD50 mice (mg/kg): about 24 intraperitoneal injection.
Originator
Auckland Cancer Chemotherapy Lab (New Zealand)
Uses
Amsacrine (Amsidyl) is used as an Investigational drug.
Uses
Amsacrine is a drug undergoing intensive trials for severe leukemia and lymphoma. It is a cytotoxic drug that binds with DNA with expressed specificity to the adenosine–tyrosine pair, thus inhibiting DNA synthesis. It has been suggested to be used for severe leukemia. A synonym of this drug is amsidyl.
Uses
Antineoplastic.
Definition
ChEBI: A sulfonamide that is N-phenylmethanesulfonamide substituted by a methoxy group at position 3 and an acridin-9-ylamino group at position 4. It exhibits antineoplastic activity.
brand name
Amsidyl (Parke-Davis);Amsakrin.
Synthesis
Amsacrine, 4-(9-acridinylamino)-3-methoxyphenyl-N-methansulfonamide (30.6.11), is made by sulfonating 4-nitro-m-anisidine with methanesulfonyl chloride, which forms a sulfonyl amide 30.6.9, and the nitro group is reduced to an amino group by hydrogen, forming 4-amino-3-methoxyphenyl-N-methansulfonamide (30.6.10). Reacting this with 9-chloroacridine gives amsacrine (30.6.11).
References
[1] nelson em, tewey km, liu lf. mechanism of antitumor drug action: poisoning of mammalian dna topoisomerase ii on dna by 4'-(9-acridinylamino)-methanesulfon-m-anisidide. proc natl acad sci u s a. 1984 mar;81(5):1361-5.
Amsacrine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| LGM Pharma | 1-(800)-881-8210 | inquiries@lgmpharma.com | United States | 2110 | 70 |
| XiaoGan ShenYuan ChemPharm co,ltd | 15527621225; 15527621225 | 1791901229@qq.com | China | 6741 | 52 |
| Beijing HuaMeiHuLiBiological Chemical | 010-56205725 | waley188@sohu.com | China | 12323 | 58 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 13913916777 | cfzhang@aikonchem.com | China | 19902 | 55 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7545 | 61 |
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2774 | 58 |
| Abblis Chemicals LLC | +1-832-373-8299 | info@abblis.com | United States | 322 | 57 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 18149758185 | sales-cpd@caerulumpharma.com | China | 3493 | 58 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
View Latest Price from Amsacrine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | Amsacrine USP/EP/BP
51264-14-3
|
$1.10 | 1g | 99.9% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2026-07-31 | Amsacrine
51264-14-3
|
$103.00-297.00 | 99.34% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-07-31 | Amsacrine
51264-14-3
|
$103.00-297.00 | 99.34% | 10g | TargetMol Chemicals Inc. |
-
- Amsacrine USP/EP/BP
51264-14-3
- $1.10
- 99.9%
- Dideu Industries Group Limited
-
- Amsacrine
51264-14-3
- $103.00-297.00
- 99.34%
- TargetMol Chemicals Inc.
-
- Amsacrine
51264-14-3
- $103.00-297.00
- 99.34%
- TargetMol Chemicals Inc.
