6-(2,2,2-Trifluoro-ethoxy)-pyridine-3-carbaldehyde
- CAS No.
- 159981-19-8
- Chemical Name:
- 6-(2,2,2-Trifluoro-ethoxy)-pyridine-3-carbaldehyde
- Synonyms
- 6-(2,2,2-Trifluoroethoxy)nicotinaldehyde;6-(2,2,2-Trifluoro-ethoxy)-pyridine-3-carbaldehyde;6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxaldehyde;3-Pyridinecarboxaldehyde, 6-(2,2,2-trifluoroethoxy)-
- CBNumber:
- CB1238707
- Molecular Formula:
- C8H6F3NO2
- Molecular Weight:
- 205.13
- MDL Number:
- MFCD06738679
- MOL File:
- 159981-19-8.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Hazard Codes | Xi |
| Risk Statements | 37/38-41-43 |
| Safety Statements | 26-36/37-39 |
6-(2,2,2-Trifluoro-ethoxy)-pyridine-3-carbaldehyde price More Price(41)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 119078 | 6-(2,2,2-Trifluoroethoxy)nicotinaldehyde | 159981-19-8 | 1.00g | $57 | 2026-05-18 | Buy |
| Matrix Scientific | 119078 | 6-(2,2,2-Trifluoroethoxy)nicotinaldehyde | 159981-19-8 | 5.00g | $268 | 2026-05-18 | Buy |
| Matrix Scientific | 119078 | 6-(2,2,2-Trifluoroethoxy)nicotinaldehyde | 159981-19-8 | 10.00g | $502 | 2026-05-18 | Buy |
| Synthonix | T48003 | 6-(2,2,2-Trifluoroethoxy)nicotinaldehyde 98% | 159981-19-8 | 100mg | $72 | 2026-05-06 | Buy |
| Synthonix | T48003 | 6-(2,2,2-Trifluoroethoxy)nicotinaldehyde 98% | 159981-19-8 | 250mg | $84 | 2026-05-06 | Buy |
6-(2,2,2-Trifluoro-ethoxy)-pyridine-3-carbaldehyde Chemical Properties, Uses, Production
Synthesis
1373862-15-7
159981-19-8
General method: (2) Diisobutylaluminum hydride (DIBAL-H, 1.01 mol/L solution in toluene, 1.95 mL, 1.97 mmol) was added slowly and dropwise to a solution in toluene (11 mL) of N-methoxy-N-methyl-6-(2,2,2-trifluoroethoxy)pyridine-3-carboxamide (432 mg, 1.64 mmol) under nitrogen protection , the reaction temperature was -78 °C. After dropwise addition, the reaction was kept at -78 °C with continued stirring for 1 hour. Subsequently, the reaction was quenched by slow dropwise addition of methanol (5 mL) to the reaction mixture and gradually warmed up to room temperature. A 50% aqueous solution of Rochelle salt (potassium sodium tartrate) (10 mL) was added and stirred for 1.5 hours at room temperature. After completion of the reaction, the mixture was extracted with chloroform, the organic layers were combined and concentrated under reduced pressure. The crude product obtained was purified by silica gel column chromatography with the eluent ratio of (hexane:ethyl acetate= 9:1→7:3) to afford the target product 6-(2,2,2-trifluoroethoxy)pyridine-3-carbaldehyde as a colorless solid (287 mg). The structure of the product was confirmed by 1H NMR (300 MHz, CDCl3): δ 4.86 (q, J = 8.4 Hz, 2H), 6.97-7.02 (m, 1H), 8.16 (dd, J = 8.6, 2.3 Hz, 1H), 8.62-8.66 (m, 1H), 10.00 (d, J = 0.6 Hz, 1H).LCMS analysis: Retention time 1.86 min (condition 3), MS ESI/APCI Dual posi: 206 [M + H]+.
References
[1] Patent: EP2687507, 2014, A1. Location in patent: Paragraph 0379
6-(2,2,2-Trifluoro-ethoxy)-pyridine-3-carbaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
6-(2,2,2-Trifluoro-ethoxy)-pyridine-3-carbaldehyde Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Tetranov Biopharm | 13526569071 | sales@leadmedpharm.com | China | 7881 | 64 |
| Shanghai Topbiochem Technology Co., Ltd | 021-58170097 | info@topbiochem.com | China | 9509 | 58 |
| SynAsst Chemical. | 021-60343070 | China | 12731 | 55 | |
| Shanghai Hong-chuang Pharma Tech Co., Ltd. | 18151128828 | hc-sales@foxmail.com | China | 2635 | 55 |
| Shanghai YuYuan Pharmaceutical Co., Ltd. | 13052276172 | product@yuyuanpharm.com | China | 401 | 55 |
| Shanghai DongYang Biotechnology Co., Ltd. | 18657622632 | chemsharker@126.com | China | 371 | 55 |
| JW & Y Pharmlab Co., Ltd. | 021-64340559 | xinyu_shi@jwypharmlab.com.cn | China | 11999 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Changzhou Hopschain Chemical Co.,Ltd. | 85528066 13775048983 | sales@hopschem.com | China | 31548 | 55 |
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