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ChemicalBook >> CAS DataBase List >>6-METHOXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE

6-METHOXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE

6-METHOXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE Structure
6-METHOXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE structure
CAS No.
22246-12-4
Chemical Name:
6-METHOXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE
Synonyms
6-METHOXY-3,4-DIHYDROISOQUINOLIN-1(2H)-ONE;105298;in-1(2H)-one;6-Methoxy-3,4-dihydroisoquinoL;6-METHOXY-3,4-1(1H)-ISOQUINOLINONE;6-methoxy-3,4-dihydroisoquinolin-1-ol;3,4-Dihydro-6-methoxy-1(2H)-isoquinolinone;6-METHOXY-3,4-DIHYDRO-1(2H)-ISOQUINOLINONE;6-METHOXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE;1(2H)-Isoquinolinone, 3,4-dihydro-6-methoxy-
CBNumber:
CB8263452
Molecular Formula:
C10H11NO2
Molecular Weight:
177.2
MDL Number:
MFCD04114865
MOL File:
22246-12-4.mol
MSDS File:
SDS
Last updated:2025-07-24 18:13:48
Product description Number Pack Size Price
6-Methoxy-3,4-dihydroisoquinolin-1(2H)-one M265453 50mg $45
6-Methoxy-3,4-dihydroisoquinolin-1(2H)-one 97% P000387188 1g $70
6-Methoxy-3,4-dihydroisoquinolin-1(2H)-one 95+% 072195 1g $79
6-Methoxy-3,4-dihydroisoquinolin-1(2H)-one CS-0018999 1g $101
6-Methoxy-3,4-dihydroisoquinolin-1(2H)-one 97% P000387188 5g $212
Request For Quotation

6-METHOXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE Properties

Melting point 136-138℃
Boiling point 439.8±45.0 °C(Predicted)
Density 1.159
storage temp. Sealed in dry,Room Temperature
pka 14.77±0.20(Predicted)
Appearance White to yellow Solid
InChI InChI=1S/C10H11NO2/c1-13-8-2-3-9-7(6-8)4-5-11-10(9)12/h2-3,6H,4-5H2,1H3,(H,11,12)
InChIKey WLQWIZAWNPYMBR-UHFFFAOYSA-N
SMILES C1(=O)C2=C(C=C(OC)C=C2)CCN1

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H332-H335
Precautionary statements  P261-P280-P305+P351+P338
HS Code  2933499090

6-METHOXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE price More Price(24)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC M265453 6-Methoxy-3,4-dihydroisoquinolin-1(2H)-one 22246-12-4 50mg $45 2021-12-16 Buy
Ark Pharm P000387188 6-Methoxy-3,4-dihydroisoquinolin-1(2H)-one 97% 22246-12-4 1g $70 2021-12-16 Buy
Matrix Scientific 072195 6-Methoxy-3,4-dihydroisoquinolin-1(2H)-one 95+% 22246-12-4 1g $79 2021-12-16 Buy
ChemScene CS-0018999 6-Methoxy-3,4-dihydroisoquinolin-1(2H)-one 22246-12-4 1g $101 2021-12-16 Buy
Ark Pharm P000387188 6-Methoxy-3,4-dihydroisoquinolin-1(2H)-one 97% 22246-12-4 5g $212 2021-12-16 Buy
Product number Packaging Price Buy
M265453 50mg $45 Buy
P000387188 1g $70 Buy
072195 1g $79 Buy
CS-0018999 1g $101 Buy
P000387188 5g $212 Buy

6-METHOXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE Chemical Properties,Uses,Production

Synthesis

N-(methoxycarbonyl)-2-(3'-methoxyphenyl)ethylamine

110192-21-7

6-METHOXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE

22246-12-4

General procedure for the synthesis of 6-(methoxy)-3,4-dihydro-1(2H)-isoquinolinone from the compound (CAS:110192-21-7): the feedstock compound (35.0 g, 167.26 mmol) was slowly added to preheated polyphosphoric acid (184 mL, 183.99 mmol) at 120 °C, keeping the temperature at 120 °C. The reaction mixture was stirred at room temperature for 6 h. Subsequently, the reaction was quenched with ice water, alkalized with K2CO3 to pH neutral and extracted with dichloromethane (DCM). The organic layers were combined, dried with anhydrous Na2SO4, filtered and the solvent concentrated. The crude product was purified by silica gel column chromatography using ethyl acetate (EtOAc)/hexane (1:1) as eluent to afford the target product 6-(methoxy)-3,4-dihydro-1(2H)-isoquinolone (38.5 g, 218 mmol, 76% yield) as a white solid.1H NMR (500 MHz, CDCl3) δ 8.01 (d, J = 8.7 Hz, 1H), 6.90 (d, J = 8.7 Hz, 1H), 6.86 (dd, J = 8.7, 2.4 Hz, 1H), 6.71 (d, J = 2.4 Hz, 1H), 3.85 (s, 3H), 3.56 (td, J = 6.6, 2.8 Hz, 2H), 2.96 (t, J = 6.6 Hz, 2H); EI/ MS m/z 177.1 [M+].

References

[1] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 2, p. 207 - 219
[2] Patent: US2017/145007, 2017, A1. Location in patent: Paragraph 0322-0325
[3] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 4, p. 789 - 801
[4] Patent: WO2012/97682, 2012, A1. Location in patent: Page/Page column 134
[5] Patent: WO2012/97684, 2012, A1. Location in patent: Page/Page column 108

6-METHOXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE Preparation Products And Raw materials

Raw materials

N-(methoxycarbonyl)-2-(3'-methoxyphenyl)ethylamine Ethyl 3-MethoxyphenethylcarbaMate 5-Methoxy-1-indanone Polyphosphoric acid Ethyl acetate

Preparation Products

6-HYDROXY-3,4-DIHYDRO-1(2H)-ISOQUINOLINONE TERT-BUTYL 6-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE 6-METHOXY-1,2,3,4-TETRAHYDRO-ISOQUINOLINE

6-METHOXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE Suppliers

Global( 117)Suppliers
Supplier Tel Email Country ProdList Advantage
Accela ChemBio Inc. 		+1-858-6993322 info@accelachem.com United States 21193 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
Wuhan Chemwish Technology Co., Ltd 		027-67849912 sales@chemwish.com CHINA 10821 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49975 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29798 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418671 +8618949823763 sales@tnjchem.com China 34563 58
Dayang Chem (Hangzhou) Co.,Ltd. 		+86-0571-88938639 +8617705817739 info@dycnchem.com China 52846 58
HANGZHOU LEAP CHEM CO., LTD. 		+86-571-87711850 market18@leapchem.com China 24727 58
PT CHEM GROUP LIMITED 		+86-85511178; peter68@ptchemgroup.com China 35425 58
GIHI CHEMICALS CO.,LIMITED 		+8618058761490 info@gihichemicals.com China 49946 58
Supplier Advantage
Accela ChemBio Inc. 		58
Alchem Pharmtech,Inc. 		58
Wuhan Chemwish Technology Co., Ltd 		58
CONIER CHEM AND PHARMA LIMITED 		58
career henan chemical co 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58
Dayang Chem (Hangzhou) Co.,Ltd. 		58
HANGZHOU LEAP CHEM CO., LTD. 		58
PT CHEM GROUP LIMITED 		58
GIHI CHEMICALS CO.,LIMITED 		58

View Lastest Price from 6-METHOXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
6-METHOXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE pictures 2020-01-10 6-METHOXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE
22246-12-4
 US $1.00 / KG 1KG 99% 200kg Career Henan Chemical Co

6-METHOXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE Spectrum

6-METHOXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE(22246-12-4)1HNMR

22246-12-4(6-METHOXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE)Related Search:

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3,4-Dihydro-2H-isoquinolin-1-one 7,8-DIHYDRO-[1,3]DIOXOLO[4,5-G]ISOQUINOLIN-5(6H)-ONE 6-METHOXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE 6,7-DIMETHOXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE 7-METHOXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE
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2,2,2-TRIFLUORO-N-(5-OXO-5,6,7,8-TETRAHYDRO[1,3]DIOXOLO[4,5-G]ISOQUINOLIN-8-YL)ACETAMIDE N-(6,7-DIMETHOXY-1-OXO-1,2,3,4-TETRAHYDRO-4-ISOQUINOLINYL)-2,2,2-TRIFLUOROACETAMIDE 6-METHOXY-2-PHENYL-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE

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6-METHOXY-3,4-DIHYDRO-1(2H)-ISOQUINOLINONE 6-METHOXY-3,4-1(1H)-ISOQUINOLINONE 1(2H)-Isoquinolinone, 3,4-dihydro-6-methoxy- 6-(Methyloxy)-3,4-dihydro-1(2H)-isoquinolinone 6-Methoxy-1,2,3,4-tetrahydroisoquinolin-1-one 6-METHOXY-3,4-DIHYDROISOQUINOLIN-1(2H)-ONE 6-METHOXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE 6-Methoxy-1-oxo-1,2,3,4-tetrahydroisoquinoline 6-methoxy-3,4-dihydroisoquinolin-1-ol 3,4-Dihydro-6-methoxy-1(2H)-isoquinolinone 105298 6-Methoxy-3,4-dihydroisoquinoL in-1(2H)-one 22246-12-4 Quinoline series