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ChemicalBook >> CAS DataBase List >>6-Methoxy-3,4-dihydro-2H-isoquinolin-1-one

6-Methoxy-3,4-dihydro-2H-isoquinolin-1-one

6-Methoxy-3,4-dihydro-2H-isoquinolin-1-one Structure
6-Methoxy-3,4-dihydro-2H-isoquinolin-1-one structure
CAS No.
22246-12-4
Chemical Name:
6-Methoxy-3,4-dihydro-2H-isoquinolin-1-one
Synonyms
6-METHOXY-3,4-DIHYDROISOQUINOLIN-1(2H)-ONE;3,4-Dihydro-6-methoxy-1(2H)-isoquinolinone;105298;in-1(2H)-one;6-Methoxy-3,4-dihydroisoquinoL;6-METHOXY-3,4-1(1H)-ISOQUINOLINONE;6-methoxy-3,4-dihydroisoquinolin-1-ol;6-METHOXY-3,4-DIHYDRO-1(2H)-ISOQUINOLINONE;6-Methoxy-3,4-dihydro-2H-isoquinolin-1-one;1(2H)-Isoquinolinone, 3,4-dihydro-6-methoxy-
CBNumber:
CB8263452
Molecular Formula:
C10H11NO2
Molecular Weight:
177.2
MDL Number:
MFCD04114865
MOL File:
22246-12-4.mol
MSDS File:
SDS
Last updated:2026-09-12 18:55:36
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6-Methoxy-3,4-dihydro-2H-isoquinolin-1-one Properties

Melting point 136-138℃
Boiling point 439.8±45.0 °C(Predicted)
Density 1.159
storage temp. Sealed in dry,Room Temperature
pka 14.77±0.20(Predicted)
Appearance White to yellow Solid
InChI InChI=1S/C10H11NO2/c1-13-8-2-3-9-7(6-8)4-5-11-10(9)12/h2-3,6H,4-5H2,1H3,(H,11,12)
InChIKey WLQWIZAWNPYMBR-UHFFFAOYSA-N
SMILES C1(=O)C2=C(C=C(OC)C=C2)CCN1

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H332-H335
Precautionary statements  P261-P280-P305+P351+P338
HS Code  2933499090

6-Methoxy-3,4-dihydro-2H-isoquinolin-1-one price More Price(53)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific OR952422 6-Methoxy-3,4-dihydro-2H-isoquinolin-1-one 97% 22246-12-4 250mg $21 2026-06-04 Buy
Apolloscientific OR952422 6-Methoxy-3,4-dihydro-2H-isoquinolin-1-one 97% 22246-12-4 1g $32 2026-06-04 Buy
Apolloscientific OR952422 6-Methoxy-3,4-dihydro-2H-isoquinolin-1-one 97% 22246-12-4 5g $79 2026-06-04 Buy
Apolloscientific OR952422 6-Methoxy-3,4-dihydro-2H-isoquinolin-1-one 97% 22246-12-4 10g $134 2026-06-04 Buy
Apolloscientific OR952422 6-Methoxy-3,4-dihydro-2H-isoquinolin-1-one 97% 22246-12-4 25g $258 2026-06-04 Buy
Product number Packaging Price Buy
OR952422 250mg $21 Buy
OR952422 1g $32 Buy
OR952422 5g $79 Buy
OR952422 10g $134 Buy
OR952422 25g $258 Buy

6-Methoxy-3,4-dihydro-2H-isoquinolin-1-one Chemical Properties, Uses, Production

Synthesis

N-(methoxycarbonyl)-2-(3'-methoxyphenyl)ethylamine

110192-21-7

6-METHOXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE

22246-12-4

General procedure for the synthesis of 6-(methoxy)-3,4-dihydro-1(2H)-isoquinolinone from the compound (CAS:110192-21-7): the feedstock compound (35.0 g, 167.26 mmol) was slowly added to preheated polyphosphoric acid (184 mL, 183.99 mmol) at 120 °C, keeping the temperature at 120 °C. The reaction mixture was stirred at room temperature for 6 h. Subsequently, the reaction was quenched with ice water, alkalized with K2CO3 to pH neutral and extracted with dichloromethane (DCM). The organic layers were combined, dried with anhydrous Na2SO4, filtered and the solvent concentrated. The crude product was purified by silica gel column chromatography using ethyl acetate (EtOAc)/hexane (1:1) as eluent to afford the target product 6-(methoxy)-3,4-dihydro-1(2H)-isoquinolone (38.5 g, 218 mmol, 76% yield) as a white solid.1H NMR (500 MHz, CDCl3) δ 8.01 (d, J = 8.7 Hz, 1H), 6.90 (d, J = 8.7 Hz, 1H), 6.86 (dd, J = 8.7, 2.4 Hz, 1H), 6.71 (d, J = 2.4 Hz, 1H), 3.85 (s, 3H), 3.56 (td, J = 6.6, 2.8 Hz, 2H), 2.96 (t, J = 6.6 Hz, 2H); EI/ MS m/z 177.1 [M+].

References

[1] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 2, p. 207 - 219
[2] Patent: US2017/145007, 2017, A1. Location in patent: Paragraph 0322-0325
[3] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 4, p. 789 - 801
[4] Patent: WO2012/97682, 2012, A1. Location in patent: Page/Page column 134
[5] Patent: WO2012/97684, 2012, A1. Location in patent: Page/Page column 108

6-Methoxy-3,4-dihydro-2H-isoquinolin-1-one Preparation Products And Raw materials

Raw materials

N-(methoxycarbonyl)-2-(3'-methoxyphenyl)ethylamine Ethyl 3-MethoxyphenethylcarbaMate 5-Methoxy-1-indanone polyphosphoric acid Ethyl acetate

Preparation Products

6-Hydroxy-3,4-dihydro-1(2H)-isoquinolinone tert-Butyl 6-hydroxy-3,4-dihydroisoquinoline-2(1H)-carboxylate 6-Methoxy-1,2,3,4-tetrahydro-isoquinoline

6-Methoxy-3,4-dihydro-2H-isoquinolin-1-one Suppliers

Global Suppliers ( 117)
Supplier Tel Email Country ProdList Advantage
Zhongshan Jukemei Biotechnology Co., Ltd. 13642727863 1009049100@qq.com China 656 58
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Accela ChemBio Co.,Ltd. 021-50795510 4000665055 marketing@accelachem.com China 10972 64
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Shanghai Ennopharm Co., Ltd. +86 (21) 6435-5022 China 4263 65
ChemShuttle, Inc. 0510-83588313-811 18800520310 sales@chemshuttle.com China 2999 62
Shanghai yirong biology science and technology co., ltd 18049974220 3060526242@qq.com China 999 60
Acorn PharmaTech Co., Ltd. 025-58395930 sales@acornpharma.com China 982 60
Shanghai Xiannuo Biotechnology Co., Ltd. 021-50718719 13918719472 China 978 58
Shanghai Topbiochem Technology Co., Ltd 021-58170097 info@topbiochem.com China 9513 58
Supplier Advantage
Zhongshan Jukemei Biotechnology Co., Ltd. 58
Wuhan Chemwish Technology Co., Ltd 56
Accela ChemBio Co.,Ltd. 64
Shanghai Hanhong Scientific Co.,Ltd. 64
Shanghai Ennopharm Co., Ltd. 65
ChemShuttle, Inc. 62
Shanghai yirong biology science and technology co., ltd 60
Acorn PharmaTech Co., Ltd. 60
Shanghai Xiannuo Biotechnology Co., Ltd. 58
Shanghai Topbiochem Technology Co., Ltd 58

View Latest Price from 6-Methoxy-3,4-dihydro-2H-isoquinolin-1-one manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
6-METHOXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE pictures 2020-01-10 6-METHOXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE
22246-12-4
 $1.00 1KG 99% 200kg Career Henan Chemical Co

6-Methoxy-3,4-dihydro-2H-isoquinolin-1-one Spectrum

6-METHOXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE(22246-12-4)1HNMR

22246-12-4 (6-Methoxy-3,4-dihydro-2H-isoquinolin-1-one) Related Search:

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6-METHOXY-3,4-DIHYDRO-1(2H)-ISOQUINOLINONE 6-METHOXY-3,4-1(1H)-ISOQUINOLINONE 1(2H)-Isoquinolinone, 3,4-dihydro-6-methoxy- 6-(Methyloxy)-3,4-dihydro-1(2H)-isoquinolinone 6-Methoxy-1,2,3,4-tetrahydroisoquinolin-1-one 6-METHOXY-3,4-DIHYDROISOQUINOLIN-1(2H)-ONE 6-Methoxy-1-oxo-1,2,3,4-tetrahydroisoquinoline 6-methoxy-3,4-dihydroisoquinolin-1-ol 105298 6-Methoxy-3,4-dihydroisoquinoL in-1(2H)-one 6-(methoxy)-3,4-dihydro-1(2H)-isoquinolineone 3,4-Dihydro-6-methoxy-1(2H)-isoquinolinone 6-Methoxy-3,4-dihydro-2H-isoquinolin-1-one 22246-12-4 Quinoline series