Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>1H-Pyrrolo[3,2-b]pyridine-2-carboxylic acid

1H-Pyrrolo[3,2-b]pyridine-2-carboxylic acid

1H-Pyrrolo[3,2-b]pyridine-2-carboxylic acid Structure
1H-Pyrrolo[3,2-b]pyridine-2-carboxylic acid structure
CAS No.
17288-35-6
Chemical Name:
1H-Pyrrolo[3,2-b]pyridine-2-carboxylic acid
Synonyms
4-Azaindole-2-carboxylic acid;4-Azaindole-2-carboxylic acid 98%;1H-Pyrrolo[3,2-b]pyridine-2-carboxylic acid;1H-pyrrolo[3,2-b]pyridine-2-carbo×ylic acid;1H-Pyrrolo[3,2-b]pyridine-2-carboxylic acid, 2-Carboxy-1H-pyrrolo[3,2b]pyridine
CBNumber:
CB12453397
Molecular Formula:
C8H6N2O2
Molecular Weight:
162.15
MDL Number:
MFCD09955613
MOL File:
17288-35-6.mol
MSDS File:
SDS
Last updated:2026-09-12 18:49:05
Request For Quotation

1H-Pyrrolo[3,2-b]pyridine-2-carboxylic acid Properties

Boiling point 446.8±25.0 °C(Predicted)
Density 1.506±0.06 g/cm3(Predicted)
storage temp. 2-8°C
pka 2.92±0.30(Predicted)
Appearance Off-white to light yellow Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H302-H319-H335
Precautionary statements  P264-P280-P302+P352-P321-P332+P313-P362-P264-P270-P301+P312-P330-P501-P264-P280-P305+P351+P338-P337+P313P
HS Code  2916399090

1H-Pyrrolo[3,2-b]pyridine-2-carboxylic acid price More Price(45)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific OR41130 4-Azaindole-2-carboxylic acid >97% 17288-35-6 250mg $21 2026-06-04 Buy
Apolloscientific OR41130 4-Azaindole-2-carboxylic acid >97% 17288-35-6 1g $32 2026-06-04 Buy
Apolloscientific OR41130 4-Azaindole-2-carboxylic acid >97% 17288-35-6 5g $149 2026-06-04 Buy
Apolloscientific OR41130 4-Azaindole-2-carboxylic acid >97% 17288-35-6 25g $734 2026-06-04 Buy
Apolloscientific OR41130 4-Azaindole-2-carboxylic acid >97% 17288-35-6 100g $2927 2026-06-04 Buy
Product number Packaging Price Buy
OR41130 250mg $21 Buy
OR41130 1g $32 Buy
OR41130 5g $149 Buy
OR41130 25g $734 Buy
OR41130 100g $2927 Buy

1H-Pyrrolo[3,2-b]pyridine-2-carboxylic acid Chemical Properties, Uses, Production

Uses

1H-Pyrrolo[3,2-b]pyridine-2-carboxylic Acid is a useful organic reagent for synthesis of substituted 4- and 6-azaindoles and indolecarboxamides as H4 receptor ligands.

Synthesis

1H-Pyrrolo[3,2-b]pyridine-2-carboxylic acid ethyl ester

17288-32-3

1H-PYRROLO[3,2-B]PYRIDINE-2-CARBOXYLIC ACID

17288-35-6

General procedure for the synthesis of 4-azaindole-2-carboxylic acid from ethyl 4-azaindole-2-carboxylate: 3-amino-2-chloropyridine (150 mg, 1.17 mmol), ethyl pyruvate (0.25 mL, 2.00 mmol), pyridinium p-toluenesulfonate (73 mg, 0.29 mmol), and tetraethoxysilane (0.26 mL, 1.18 mmol) were suspended in 0.4 mL of pyridine and stirred at 20 °C for 24 hours. Tetrakis(triphenylphosphine)palladium (70 mg, 0.06 mmol) and N,N-dicyclohexylmethylamine (0.35 mL, 2.06 mmol) were subsequently added, and the reaction mixture was placed in a microwave reactor, heated to 160 °C, and held for 20 min. After completion of the reaction, the reaction mixture was diluted with 100 mL of dichloromethane and extracted twice with 50 mL of half-saturated aqueous sodium bicarbonate. The organic layer was dried over anhydrous sodium sulfate, concentrated under reduced pressure, and the crude product was purified by silica gel column chromatography (P3) to afford ethyl 1H-pyrrolo[3,2-b]pyridine-2-carboxylate (190 mg, 1.00 mmol). The ester was dissolved in a mixture of 17 mL ethanol and 5 mL water and lithium hydroxide (120 mg, 5.00 mmol) was added. After 16 hours of reaction, the pH of the reaction mixture was adjusted to 4 and the solvent was evaporated under vacuum. The crude product was purified by acidic ion exchange resin (Strata-X-C, Phenomenex) to afford 4-azaindole-2-carboxylic acid (155 mg, 82% yield). Product purity >95%; mass spectrum (ESI) m/z 163 (M + H)+; 1H NMR (DMSO) δ (ppm) 13.34 (br, 1H), 8.77 (d, J = 5.3 Hz, 1H), 8.53 (d, J = 8.3 Hz, 1H), 7.73 (dd, J = 5.4 Hz, J = 8.3 Hz, 1H), 7.33 ( br, 1H); 13C NMR (500 MHz, DMSO) δ (ppm) 161.4 (s), 138.0 (s), 136.1 (s), 135.8 (s), 132.7 (s), 128.6 (s), 119.6 (s), 101.2 (s).

References

[1] European Journal of Medicinal Chemistry, 2012, vol. 54, p. 660 - 668
[2] Patent: WO2004/104001, 2004, A2. Location in patent: Page 42-43

1H-Pyrrolo[3,2-b]pyridine-2-carboxylic acid synthesis

17288-32-3
17288-35-6
Synthesis of 1H-Pyrrolo[3,2-b]pyridine-2-carboxylic acid from 1H-Pyrrolo[3,2-b]pyridine-2-carboxylic acid ethyl ester

1H-Pyrrolo[3,2-b]pyridine-2-carboxylic acid Preparation Products And Raw materials

Raw materials

1H-Pyrrolo[3,2-b]pyridine-2-carboxylic acid ethyl ester Lithium hydroxide Ethanol Water

Preparation Products

1H-Pyrrolo[3,2-b]pyridine-2-carboxylic acid Suppliers

Global Suppliers ( 83)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
JinYan Chemicals(ShangHai) Co.,Ltd. 13817811078 sales@jingyan-chemical.com China 9963 60
Jia Xing Isenchem Co.,Ltd 0573-85285100 18627885956 isenchem@163.com China 9389 66
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418 sales@chemreagents.com United States 10174 62
Adamas Reagent, Ltd. 400-6009262 15618770481 yhx@titansci.com China 14098 59
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd. 17702719238 sales@sun-shinechem.com China 1197 64
Shijiazhuang suchen Chemical Technology Co. LTD 186-33933494 18032288352 1130239@qq.com China 192 60
Shanghai Yolne Chemical Co., Ltd. 021-62960152 934678158@qq.com China 9886 55
Shanghai Raise Chemical Technology Co.,Ltd +86-021-50935922 China 7854 55
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Supplier Advantage
J & K SCIENTIFIC LTD. 76
JinYan Chemicals(ShangHai) Co.,Ltd. 60
Jia Xing Isenchem Co.,Ltd 66
Pure Chemistry Scientific Inc. 62
Adamas Reagent, Ltd. 59
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd. 64
Shijiazhuang suchen Chemical Technology Co. LTD 60
Shanghai Yolne Chemical Co., Ltd. 55
Shanghai Raise Chemical Technology Co.,Ltd 55
Bide Pharmatech Ltd. 60

View Latest Price from 1H-Pyrrolo[3,2-b]pyridine-2-carboxylic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1H-PYRROLO[3,2-B]PYRIDINE-2-CARBOXYLIC ACID pictures 2020-01-13 1H-PYRROLO[3,2-B]PYRIDINE-2-CARBOXYLIC ACID
17288-35-6
 $1.00 1KG 99% 100KG Career Henan Chemical Co

1H-Pyrrolo[3,2-b]pyridine-2-carboxylic acid Spectrum

1H-PYRROLO[3,2-B]PYRIDINE-2-CARBOXYLIC ACID(17288-35-6)1HNMR

17288-35-6 (1H-Pyrrolo[3,2-b]pyridine-2-carboxylic acid) Related Search:

1H-Pyrrolo[3,2-c]pyridine-2-carboxylic acid ethyl ester 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid ethyl 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylate 1H-Pyrrolo[2,3-b]pyridine, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)- ethyl 5-chloro-1H-pyrrolo[3,2-b]pyridine-2-carboxylate
Methyl 3-bromo-1H-pyrrolo-[3,2-b]pyridine-2-carboxylate Methyl 7-chloro-1H-pyrrolo[3,2-b]pyridine-2-carboxylate 5-(Benzyloxy)-1H-pyrrolo[3,2-b]pyridine-2-carboxylic acid 5-Methoxy-1H-pyrrolo[3,2-b]pyridine-2-carboxylic acid 1H-Pyrrolo[3,2-b]pyridine-2-carboxylic acid
Methyl 1H-pyrrolo[3,2-b]pyridine-2-carboxylate Methyl 6-cyano-1H-pyrrolo-[3,2-b]pyridine-2-carboxylate Methyl 5-(trifluoromethyl)-1H-pyrrolo[3,2-b]pyridine-2-carboxylate Ethyl 6-cyano-1H-pyrrolo[3,2-b]pyridine-2-carboxylate Methyl 6-cyano-1-methyl-1H-pyrrolo[3,2-b]pyridine-2-carboxylate
Methyl 5-(trifluoromethyl)-1-tosyl-1H-pyrrolo[3,2-b]pyridine-2-carboxylate Methyl 6-formyl-1-methyl-1H-pyrrolo[3,2-b]pyridine-2-carboxylate Methyl 1-tosyl-1H-pyrrolo[3,2-b]pyridine-2-carboxylate

1of4

1H-Pyrrolo[3,2-b]pyridine-2-carboxylic acid, 2-Carboxy-1H-pyrrolo[3,2b]pyridine 1H-pyrrolo[3,2-b]pyridine-2-carbo×ylic acid 4-Azaindole-2-carboxylic acid 4-Azaindole-2-carboxylic acid 98% 1H-Pyrrolo[3,2-b]pyridine-2-carboxylic acid 17288-35-6