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1H-Pyrrolo[3,2-b]pyridine-2-carboxylic acid ethyl ester

1H-Pyrrolo[3,2-b]pyridine-2-carboxylic acid ethyl ester Structure
1H-Pyrrolo[3,2-b]pyridine-2-carboxylic acid ethyl ester structure
CAS No.
17288-32-3
Chemical Name:
1H-Pyrrolo[3,2-b]pyridine-2-carboxylic acid ethyl ester
Synonyms
Ethyl 1H-pyrrolo[3,2-b]pyridine-2-carboxylate;SW-76;SWF-76;4-azaindole-2-ethyl formate;Ethyl 4-azaindole-2-carbo...;Ethyl 4-azaindole-2-carboxylate;4,4,5,7-tetramethyl-3,4-dihydrocoumarin;4-Azaindole-2-carboxylic acid ethyl ester;ethyl 1H-pyrrolo[3,2-b]pyridine-2-carbo×ylate;1H-Pyrrolo[3,2-b]pyridine-2-carboxylic acid ethyl ester
CBNumber:
CB72514656
Molecular Formula:
C10H10N2O2
Molecular Weight:
190.2
MDL Number:
MFCD11053752
MOL File:
17288-32-3.mol
MSDS File:
SDS
Last updated:2026-05-28 03:34:20
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1H-Pyrrolo[3,2-b]pyridine-2-carboxylic acid ethyl ester Properties

Melting point 179-181℃
Boiling point 356℃
Density 1.272
Flash point 169℃
storage temp. Sealed in dry,Room Temperature
pka 12.67±0.40(Predicted)
Appearance Off-white to yellow Solid
InChI InChI=1S/C10H10N2O2/c1-2-14-10(13)9-6-8-7(12-9)4-3-5-11-8/h3-6,12H,2H2,1H3
InChIKey NOWHXIDXMNNYBL-UHFFFAOYSA-N
SMILES C12C=C(C(OCC)=O)NC1=CC=CN=2

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H335-H302-H319-H315
Precautionary statements  P264-P270-P301+P312-P330-P501-P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362
HS Code  2933998090

1H-Pyrrolo[3,2-b]pyridine-2-carboxylic acid ethyl ester price More Price(36)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific OR321483 Ethyl 1H-pyrrolo[3,2-b]pyridine-2-carboxylate >97% 17288-32-3 250mg $21 2026-06-04 Buy
Apolloscientific OR321483 Ethyl 1H-pyrrolo[3,2-b]pyridine-2-carboxylate >97% 17288-32-3 1g $24 2026-06-04 Buy
Apolloscientific OR321483 Ethyl 1H-pyrrolo[3,2-b]pyridine-2-carboxylate >97% 17288-32-3 5g $60 2026-06-04 Buy
Apolloscientific OR321483 Ethyl 1H-pyrrolo[3,2-b]pyridine-2-carboxylate >97% 17288-32-3 25g $287 2026-06-04 Buy
Apolloscientific OR321483 Ethyl 1H-pyrrolo[3,2-b]pyridine-2-carboxylate >97% 17288-32-3 100g $948 2026-06-04 Buy
Product number Packaging Price Buy
OR321483 250mg $21 Buy
OR321483 1g $24 Buy
OR321483 5g $60 Buy
OR321483 25g $287 Buy
OR321483 100g $948 Buy

1H-Pyrrolo[3,2-b]pyridine-2-carboxylic acid ethyl ester Chemical Properties, Uses, Production

Synthesis

ethyl 2-hydroxy-3-(3-nitropyridin-2-yl)acrylate

23596-34-1

1H-Pyrrolo[3,2-b]pyridine-2-carboxylic acid ethyl ester

17288-32-3

The general procedure for the synthesis of ethyl 4-azaindole-2-carboxylate (4a-1) from the compound (CAS: 23596-34-1) was as follows: ethyl 1H-pyrrolo[3,2-b]pyridine-2-carboxylate (56.8 g, 0.24 mol), ethanol (850 mL), and 10% Pd/C (5.7 g, 10 wt%) were added to a 2 L thick-walled Parr reactor. The reactor was connected to the Parr hydrogenation unit and after flushing with hydrogen, the orange slurry was pressurized to 45 psi. the reaction temperature was raised to 57 °C by shaking for 1 h at room temperature. After the temperature of the reaction mixture stabilized at 35°C, it was slowly heated to 40°C and maintained for 3 hr. After confirming the completion of the reaction by TLC (silica gel plate, unfolding agent was CH2Cl2 solution with 1% MeOH), the reaction mixture was cooled to room temperature, the slurry was filtered through Celite and the filter cake was washed with ethanol (4 x 200 mL). The yellow filtrate was concentrated to obtain a solid (41.6 g), to which ethyl acetate (302 mL) was added and heated on a steam bath. After cooling the mixture to room temperature, heptane (600 mL) was added to precipitate the product. The mixture was stirred in an ice bath for 1 hour and then filtered and the filter cake was washed with heptane (100 mL). The filter cake was dried at 50 °C, 0.1 mmHg for 24 h to give light gray solid 4a-1 (36.6 g, 81% yield).1H NMR (DMSO-d6) δ 1.36 (t, 3H, J=7.0 Hz), 4.36 (q, 2H, J=7.0 Hz), 7.19 (s, 1H), 7.25 (dd, 1H, J=4.5, 8.1 Hz), 7.82 (d, 1H, J=8.1 Hz), 8.44 (d, 1H, J=4.5 Hz), 12.11 (s, 1H).

References

[1] Organic Process Research and Development, 2011, vol. 15, # 5, p. 1040 - 1045
[2] Patent: US2005/131012, 2005, A1. Location in patent: Page/Page column 14
[3] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 1, p. 339 - 342

1H-Pyrrolo[3,2-b]pyridine-2-carboxylic acid ethyl ester Preparation Products And Raw materials

Raw materials

Ethyl pyruvate ethyl 2-hydroxy-3-(3-nitropyridin-2-yl)acrylate 2-Propenoic acid, 2-hydroxy-3-(3-nitro-2-pyridinyl)-, ethyl ester, (2Z)- 2-Chloro-3-pyridinamine Ethanol
Hydrogen

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Preparation Products

3-broMo-1H-pyrrolo[3,2-b]pyridine-2-carboxylic acid (1H-Pyrrolo[3,2-b]pyridin-2-yl)MethanaMine

1H-Pyrrolo[3,2-b]pyridine-2-carboxylic acid ethyl ester Suppliers

Global Suppliers ( 99)
Supplier Tel Email Country ProdList Advantage
Tianjin Ruide Famo Technology Co., Ltd 13821803402 RD_PHARM@163.com China 842 58
Zhongshan Kexin Biotechnology Co., Ltd 0760-+86-0760-88665202 13824707890 sunmaohaohao@163.com China 142 58
JinYan Chemicals(ShangHai) Co.,Ltd. 13817811078 sales@jingyan-chemical.com China 9963 60
Jia Xing Isenchem Co.,Ltd 0573-85285100 18627885956 isenchem@163.com China 9389 66
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418 sales@chemreagents.com United States 10174 62
Adamas Reagent, Ltd. 400-6009262 15618770481 yhx@titansci.com China 14098 59
China DongFan Chemical Co.,LTD 86-0571-85151182 China 5681 66
Shijiazhuang suchen Chemical Technology Co. LTD 186-33933494 18032288352 1130239@qq.com China 192 60
Shanghai Aladdin Bio-Chem Technology Co.,LTD 400-6206333 13167063860 anhua.mao@aladdin-e.com China 29977 65
Shanghai Yolne Chemical Co., Ltd. 021-62960152 934678158@qq.com China 9886 55
Supplier Advantage
Tianjin Ruide Famo Technology Co., Ltd 58
Zhongshan Kexin Biotechnology Co., Ltd 58
JinYan Chemicals(ShangHai) Co.,Ltd. 60
Jia Xing Isenchem Co.,Ltd 66
Pure Chemistry Scientific Inc. 62
Adamas Reagent, Ltd. 59
China DongFan Chemical Co.,LTD 66
Shijiazhuang suchen Chemical Technology Co. LTD 60
Shanghai Aladdin Bio-Chem Technology Co.,LTD 65
Shanghai Yolne Chemical Co., Ltd. 55

View Latest Price from 1H-Pyrrolo[3,2-b]pyridine-2-carboxylic acid ethyl ester manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1H-Pyrrolo[3,2-b]pyridine-2-carboxylic acid ethyl ester pictures 2020-01-13 1H-Pyrrolo[3,2-b]pyridine-2-carboxylic acid ethyl ester
17288-32-3
 $5.00 1KG 98% 100KG Career Henan Chemical Co

1H-Pyrrolo[3,2-b]pyridine-2-carboxylic acid ethyl ester Spectrum

1H-Pyrrolo[3,2-b]pyridine-2-carboxylic acid ethyl ester(17288-32-3)1HNMR

17288-32-3 (1H-Pyrrolo[3,2-b]pyridine-2-carboxylic acid ethyl ester) Related Search:

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1H-Pyrrolo[3,2-b]pyridine-2-carboxylic acid ethyl ester Ethyl 4-azaindole-2-carboxylate Ethyl 4-azaindole-2-carbo... ethyl 1H-pyrrolo[3,2-b]pyridine-2-carbo×ylate 4-Azaindole-2-carboxylic acid ethyl ester 4,4,5,7-tetramethyl-3,4-dihydrocoumarin SWF-76 SW-76 4-azaindole-2-ethyl formate Ethyl 1H-pyrrolo[3,2-b]pyridine-2-carboxylate 17288-32-3