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ChemicalBook >> CAS DataBase List >>1-(2-[4-(6-Fluoro-1H-indol-3-yl)-3,6-dihydro-2H-pyridin-1-yl]-ethyl)-3-isopropyl-6-methanesulfonyl-3,4-dihydro-1H-benzo[1,2,6]thiadiazine 2,2-dioxide

1-(2-[4-(6-Fluoro-1H-indol-3-yl)-3,6-dihydro-2H-pyridin-1-yl]-ethyl)-3-isopropyl-6-methanesulfonyl-3,4-dihydro-1H-benzo[1,2,6]thiadiazine 2,2-dioxide

1-(2-[4-(6-Fluoro-1H-indol-3-yl)-3,6-dihydro-2H-pyridin-1-yl]-ethyl)-3-isopropyl-6-methanesulfonyl-3,4-dihydro-1H-benzo[1,2,6]thiadiazine 2,2-dioxide Structure
1-(2-[4-(6-Fluoro-1H-indol-3-yl)-3,6-dihydro-2H-pyridin-1-yl]-ethyl)-3-isopropyl-6-methanesulfonyl-3,4-dihydro-1H-benzo[1,2,6]thiadiazine 2,2-dioxide structure
CAS No.
271780-64-4
Chemical Name:
1-(2-[4-(6-Fluoro-1H-indol-3-yl)-3,6-dihydro-2H-pyridin-1-yl]-ethyl)-3-isopropyl-6-methanesulfonyl-3,4-dihydro-1H-benzo[1,2,6]thiadiazine 2,2-dioxide
Synonyms
LY-393558;Zymosan (ZM), 95%;1-[2-[4-(6-fluoro-1H-indol-3-yl)-3,6-dihydro-2H-pyridin-1-yl]ethyl]-6-methylsulfonyl-3-propan-2-yl-4H-2λ6,1,3-benzothiadiazine 2,2-dioxide;1-(2-[4-(6-Fluoro-1H-indol-3-yl)-3,6-dihydro-2H-pyridin-1-yl]-ethyl)-3-isopropyl-6-methanesulfonyl-3,4-dihydro-1H-benzo[1,2,6]thiadiazine 2,2-dioxide;1-{2-[4-(6-Fluoro-1H-Indol-3-Yl)-3,6-Dihydro-1(2H)-Pyridinyl]Ethyl}-3-Isopropyl-6-(Methylsulfonyl)-3,4-Dihydro-1H-2,1,3-Benzothiadia zine 2,2-Dioxide;1-[2-[4-(6-Fluoro-1H-indol-3-yl)-3,6-dihydro-1(2H)-pyridinyl]ethyl]-3,4-dihydro-3-(1-methylethyl)-6-(methylsulfonyl)-1H-2,1,3-benzothiadiazine-2,2-dioxide;1H-2,1,3-BENZOTHIADIAZINE, 1-[2-[4-(6-FLUORO-1H-INDOL-3-YL)-3,6-DIHYDRO-1(2H)-PYRIDINYL]ETHYL]-3,4-DIHYDRO-3-(1-METHYLETHYL)-6-(METHYLSULFONYL)-, 2,2-DIOXIDE
CBNumber:
CB12454086
Molecular Formula:
C26H31FN4O4S2
Molecular Weight:
546.68
MDL Number:
MFCD10565930
MOL File:
271780-64-4.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:49:05
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1-(2-[4-(6-Fluoro-1H-indol-3-yl)-3,6-dihydro-2H-pyridin-1-yl]-ethyl)-3-isopropyl-6-methanesulfonyl-3,4-dihydro-1H-benzo[1,2,6]thiadiazine 2,2-dioxide Properties

Boiling point 785.7±60.0 °C(Predicted)
Density 1.359±0.06 g/cm3(Predicted)
storage temp. Store at +4°C
solubility Soluble to 100 mM in DMSO
form Powder
pka 16.46±0.30(Predicted)
color Light yellow to yellow

1-(2-[4-(6-Fluoro-1H-indol-3-yl)-3,6-dihydro-2H-pyridin-1-yl]-ethyl)-3-isopropyl-6-methanesulfonyl-3,4-dihydro-1H-benzo[1,2,6]thiadiazine 2,2-dioxide price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 32775 LY393558 ≥98% 271780-64-4 1mg $37 2026-04-30 Buy
Cayman Chemical 32775 LY393558 ≥98% 271780-64-4 5mg $99 2026-04-30 Buy
Cayman Chemical 32775 LY393558 ≥98% 271780-64-4 10mg $181 2026-04-30 Buy
Usbiological 454018 LY 393558 271780-64-4 10mg $425 2026-06-03 Buy
Usbiological 454018 LY 393558 271780-64-4 50mg $991 2026-06-03 Buy
Product number Packaging Price Buy
32775 1mg $37 Buy
32775 5mg $99 Buy
32775 10mg $181 Buy
454018 10mg $425 Buy
454018 50mg $991 Buy

1-(2-[4-(6-Fluoro-1H-indol-3-yl)-3,6-dihydro-2H-pyridin-1-yl]-ethyl)-3-isopropyl-6-methanesulfonyl-3,4-dihydro-1H-benzo[1,2,6]thiadiazine 2,2-dioxide Chemical Properties, Uses, Production

Uses

LY 393558 acts as a 5HT1B/D receptor antagonist which has been shown to limit serotonin reuptake on extracellular levels. Potential use in the treatment of IBS.

Biological Activity

Dual 5-HT 1B/1D receptor antagonist (pK B values are 9.05 and 8.98 respectively) and 5-HT re-uptake inhibitor (pIC 50 = 8.48). Potently antagonizes terminal autoreceptor activity in vitro and increases extracellular 5-HT levels above those evoked by fluoxetine in vivo . Also acts as an antagonist at 5-HT 2A and 5-HT 2B receptors (pK i values are 7.29 and 7.35 respectively).

in vivo

LY393558 (1-20 mg/kg; p.o., single) raises extracellular levels of 5-HT to 200-250% at 1 mg/kg in guinea pigs model, while levels of 5-HT to approximately 1500% at the highest dose 20 mg/kg[1].
LY393558 (20 mg/kg; p.o., single) completely abolishes the reduction of levels of 5-HT induced by tetrodotoxin (1μM) in guinea pigs model[1].
LY393558 (1-20 mg/kg; p.o., single) significantly increases extracellular levels of 5-HT in rats model[1].
LY393558 (5 mg/kg/day; p.o., 21 days) can still elicit a further increase in extracellular 5-HT in chronic treatment[1].

Animal Model:Female Dunkin Hartley guinea pigs (350-400 g)[1]
Dosage:1-20 mg/kg
Administration:p.o., single
Result:Extracellular levels of 5-HT reached 200-250% at 1 mg/kg, while levels of 5-HT reached approximately 1500% at the highest dose 20 mg/kg.
Animal Model:Female Dunkin Hartley guinea pigs (350-400 g)[1]
Dosage:20 mg/kg
Administration:p.o., single
Result:Completely abolished the reduction of levels of 5-HT induced by tetrodotoxin (1μM).
Animal Model:Male Lister Hooded rats (290-320 g)[1]
Dosage:1-20 mg/kg
Administration:p.o., single
Result:Significantly increased extracellular levels of 5-HT.
Animal Model:Male Lister Hooded rats (290-320 g)[1]
Dosage:5 mg/kg/day
Administration:p.o., 21 days
Result:Still elicited a further increase in extracellular 5-HT in chronic treatment.

1-(2-[4-(6-Fluoro-1H-indol-3-yl)-3,6-dihydro-2H-pyridin-1-yl]-ethyl)-3-isopropyl-6-methanesulfonyl-3,4-dihydro-1H-benzo[1,2,6]thiadiazine 2,2-dioxide Preparation Products And Raw materials

Raw materials

Preparation Products

1-(2-[4-(6-Fluoro-1H-indol-3-yl)-3,6-dihydro-2H-pyridin-1-yl]-ethyl)-3-isopropyl-6-methanesulfonyl-3,4-dihydro-1H-benzo[1,2,6]thiadiazine 2,2-dioxide Suppliers

Global Suppliers ( 33)
Supplier Tel Email Country ProdList Advantage
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 9920 65
EMMX Biotechnology LLC 888-539-0666 info@emmx.com United States 8435 60
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9799 58
Shanghai Chaolan Chemical Technology Center QQ：65489617 13301690235 Sales@ATKchemical.com China 9729 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11123 58
Energy Chemical 021-58432009 400-005-6266 marketing@energy-chemical.com China 44871 58
TargetMol Chemicals Inc. 4008200310 15002144251 marketing@tsbiochem.com China 24951 58
Nantong QuanYi Biotechnology Co., Ltd 0513-66337626 18051384581 sales@chemhifuture.com China 5985 58
Supplier Advantage
3B Pharmachem (Wuhan) International Co.,Ltd. 69
BOC Sciences 65
EMMX Biotechnology LLC 60
Shanghai EFE Biological Technology Co., Ltd. 58
Shanghai Chaolan Chemical Technology Center 58
TargetMol Chemicals Inc. 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Energy Chemical 58
TargetMol Chemicals Inc. 58
Nantong QuanYi Biotechnology Co., Ltd 58

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LY 393558 pictures 2026-07-15 LY 393558
271780-64-4
 $120.00-575.00 10g TargetMol Chemicals Inc.
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    271780-64-4
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271780-64-4 (1-(2-[4-(6-Fluoro-1H-indol-3-yl)-3,6-dihydro-2H-pyridin-1-yl]-ethyl)-3-isopropyl-6-methanesulfonyl-3,4-dihydro-1H-benzo[1,2,6]thiadiazine 2,2-dioxide) Related Search:

1-(2-[4-(6-Fluoro-1H-indol-3-yl)-3,6-dihydro-2H-pyridin-1-yl]-ethyl)-3-isopropyl-6-methanesulfonyl-3,4-dihydro-1H-benzo[1,2,6]thiadiazine 2,2-dioxide 6-Fluoro-3-(1,2,3,6-tetrahydro-pyridin-4-yl)-1H-indole ACT-132577 LU 208075-d3 PRX-08066
ACT 373898

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1H-2,1,3-BENZOTHIADIAZINE, 1-[2-[4-(6-FLUORO-1H-INDOL-3-YL)-3,6-DIHYDRO-1(2H)-PYRIDINYL]ETHYL]-3,4-DIHYDRO-3-(1-METHYLETHYL)-6-(METHYLSULFONYL)-, 2,2-DIOXIDE 1-[2-[4-(6-Fluoro-1H-indol-3-yl)-3,6-dihydro-1(2H)-pyridinyl]ethyl]-3,4-dihydro-3-(1-methylethyl)-6-(methylsulfonyl)-1H-2,1,3-benzothiadiazine-2,2-dioxide LY-393558 1-{2-[4-(6-Fluoro-1H-Indol-3-Yl)-3,6-Dihydro-1(2H)-Pyridinyl]Ethyl}-3-Isopropyl-6-(Methylsulfonyl)-3,4-Dihydro-1H-2,1,3-Benzothiadia zine 2,2-Dioxide 1-[2-[4-(6-fluoro-1H-indol-3-yl)-3,6-dihydro-2H-pyridin-1-yl]ethyl]-6-methylsulfonyl-3-propan-2-yl-4H-2λ6,1,3-benzothiadiazine 2,2-dioxide Zymosan (ZM), 95% 1-(2-[4-(6-Fluoro-1H-indol-3-yl)-3,6-dihydro-2H-pyridin-1-yl]-ethyl)-3-isopropyl-6-methanesulfonyl-3,4-dihydro-1H-benzo[1,2,6]thiadiazine 2,2-dioxide 271780-64-4 C26H34FN4O4S2 C26H31FN4O4S2