Cyclohexanecarbonitrile, 4,4-difluoro-
- CAS No.
- 922728-21-0
- Chemical Name:
- Cyclohexanecarbonitrile, 4,4-difluoro-
- Synonyms
- 4,4-difluorocyclohexane-1-carbonitrile;158106;4,4-DIFLUOROCYCLOHEXANECARBONITRILE;Cyclohexanecarbonitrile, 4,4-difluoro-;4,4-difluoro-1-cyclohexanecarbonitrile
- CBNumber:
- CB12466331
- Molecular Formula:
- C7H9F2N
- Molecular Weight:
- 145.15
- MDL Number:
- MFCD11847832
- MOL File:
- 922728-21-0.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H335-H312-H319-H315-H302-H332 |
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P280-P302+P352-P312-P322-P363-P501-P264-P270-P301+P312-P330-P501-P261-P271-P304+P340-P312-P264-P280-P305+P351+P338-P337+P313P |
Cyclohexanecarbonitrile, 4,4-difluoro- price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | FD82646 | 4,4-Difluorocyclohexanecarbonitrile | 922728-21-0 | 5g | $900 | 2026-06-04 | Buy |
| Biosynth | FD82646 | 4,4-Difluorocyclohexanecarbonitrile | 922728-21-0 | 10g | $908.6 | 2026-06-04 | Buy |
| Matrix Scientific | 305151 | 4,4-Difluorocyclohexanecarbonitrile | 922728-21-0 | 1.00g | $69 | 2026-05-19 | Buy |
| Matrix Scientific | 305151 | 4,4-Difluorocyclohexanecarbonitrile | 922728-21-0 | 5.00g | $226 | 2026-05-19 | Buy |
| Matrix Scientific | 305151 | 4,4-Difluorocyclohexanecarbonitrile | 922728-21-0 | 25.00g | $742 | 2026-05-19 | Buy |
Cyclohexanecarbonitrile, 4,4-difluoro- Chemical Properties, Uses, Production
Synthesis
34916-10-4
922728-21-0
459-53-0
General procedure for the synthesis of 4,4-difluorocyclohexanecarbonitrile and 4-fluorocyclohex-3-ene-1-carbonitrile from 4-oxocyclohexanecarbonitrile: A solution of (diethylamino)sulfur trifluoride (46.7 g, 289 mmol) in dichloromethane (200 mL) was added slowly and dropwise at 0 °C to a solution of 4-oxocyclohexanecarbonitrile (32.4 g, 263 mmol) in dichloromethane ( 400 mL) solution. The reaction mixture was stirred at this temperature for 2 hours and then the reaction was quenched with deionized water (100 mL). The organic phase was separated and dried over anhydrous magnesium sulfate. After concentrating the solvent, a 7:3 mixture of 4,4-difluorocyclohexanecarbonitrile and 4-fluorocyclohex-3-ene-1-carbonitrile was obtained. Another 77% m-chloroperoxybenzoic acid (MCPBA, 45 g, 200 mmol) was stirred in chloroform (600 mL) for 30 min and the solution was dried over anhydrous sodium sulfate and filtered. A mixture of 4,4-difluorocyclohexanecarbonitrile and 4-fluorocyclohex-3-ene-1-carbonitrile obtained above was added to the MCPBA solution and stirred at room temperature for 18 hours. After completion of the reaction, the reaction mixture was washed with 1.5 M sodium hydroxide solution (3 x 300 mL) and the organic phase was dried with anhydrous magnesium sulfate. After concentrating the solvent, the residue was distilled under reduced pressure to give the pure target compound 4,4-difluorocyclohexanecarbonitrile as a colorless liquid. Yield 18.2 g (47%).1H NMR (400 MHz, chloroform-d) δ 1.86-1.96 (m, 1H), 1.95-2.03 (m, 5H), 2.03-2.22 (m, 2H), 2.68-2.85 (m, 1H).
References
[1] Patent: WO2007/13848, 2007, A1. Location in patent: Page/Page column 9
Cyclohexanecarbonitrile, 4,4-difluoro- Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9409 | 55 |
| Santai Labs, Inc. | 519-85601385 | marketing@santailabs.com | China | 891 | 62 |
| Wuhan TCASChem Technology Co., Ltd. | 027-86697669 13986148687 | sales@tcaschem.com | China | 3982 | 55 |
| Nanjing Norris-Pharm Technology Co., Ltd | 13901585132 | sales@norris-pharm.com | China | 8869 | 55 |
| Shanghai Jian Chao Chemical Technology Co., Ltd. | 150-2103-5486 18017383231 | 983544897@qq.com | China | 9335 | 55 |
| Chengdu 3S Pharmaceutical Technology Co., Ltd. | 028-62577698; 19950139520 | cd_chemical@126.com | China | 293 | 56 |
| DebyeTec.com Inc. | 18086626237 18086626237 | 2693528373@qq.com | China | 2999 | 56 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Aikon International Limited | 025-66061636 19370895928 | qqyang@aikonchem.com | China | 15810 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 | sales@sarms4muscle.com | China | 10378 | 58 |
View Latest Price from Cyclohexanecarbonitrile, 4,4-difluoro- manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | CYCLOHEXANECARBONITRILE, 4,4-DIFLUORO-
922728-21-0
|
$1.00-101.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd |
-
- CYCLOHEXANECARBONITRILE, 4,4-DIFLUORO-
922728-21-0
- $1.00-101.00
- 99%
- Henan Fengda Chemical Co., Ltd
