Boc-Thr-OBzl
- CAS No.
- 33662-26-9
- Chemical Name:
- Boc-Thr-OBzl
- Synonyms
- Benzyl (tert-butoxycarbonyl)-L-threoninate;Boc-Thr-OBzl;Boc-L-Thr-OBzl;Boc-L-threonine benzyl ester;(Tert-Butoxy)Carbonyl Thr-OBzl;N-Boc-L-threonine Benzyl Ester;BO-C-L-threonineaminoacidbenzyl ester;N-tert-Butoxycarbonyl-L-threonine benzyl ester;N-α-(t-Butoxycarbonyl)-L-threonine benzyl ester;(2S,3R)-Benzyl 2-((tert-butoxycarbonyl)amino)-3-hydroxybutanoate
- CBNumber:
- CB12467747
- Molecular Formula:
- C16H23NO5
- Molecular Weight:
- 309.36
- MDL Number:
- MFCD11974981
- MOL File:
- 33662-26-9.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
Boc-Thr-OBzl price More Price(21)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | FB111285 | Boc-Thr-OBzl | 33662-26-9 | 5g | $900 | 2026-06-04 | Buy |
| Biosynth | FB111285 | Boc-Thr-OBzl | 33662-26-9 | 10g | $900 | 2026-06-04 | Buy |
| Biosynth | FB111285 | Boc-Thr-OBzl | 33662-26-9 | 2g | $900 | 2026-06-04 | Buy |
| Biosynth | FB111285 | Boc-Thr-OBzl | 33662-26-9 | 25g | $1276.5 | 2026-06-04 | Buy |
| Biosynth | FB111285 | Boc-Thr-OBzl | 33662-26-9 | 50g | $2221.5 | 2026-06-04 | Buy |
Boc-Thr-OBzl Chemical Properties,Uses,Production
Uses
Boc-Thr-Obzl is used in preparation of of substituted Oxopyridine derivatives as factor XIa and plasma kallikrein inhibitors useful in treating Thrombotic or Thromboembolic diseases.
Synthesis
2592-18-9
100-39-0
![Threonine, N-[(1,1-dimethylethoxy)carbonyl]-, phenylmethyl ester](/CAS/20210305/GIF/140422-54-4.gif)
140422-54-4
The general procedure for the synthesis of the target compound (CAS: 140422-54-4) from (2S,3R)-2-((tert-butoxycarbonyl)amino)-3-hydroxybutanoic acid (Boc-L-threonine, 1.32 g, 6.03 mmol) and benzyl bromide (783 μL, 1.13 g, 6.63 mmol) was as follows: dissolve Boc-L-threonine in methanol (40 mL) and cesium carbonate (Cs2CO3, 1.08 g, 3.32 mmol) was added. After complete dissolution, the solution was concentrated. Subsequently, the concentrate was dissolved in N,N-dimethylformamide (DMF, 20 mL) and benzyl bromide was added. The reaction mixture was stirred at room temperature for 18 hours. After completion of the reaction, the solvent was removed by evaporation. The crude product was dissolved in water (20 mL) and extracted with dichloromethane (3 × 20 mL). The organic phase was dried over anhydrous magnesium sulfate (MgSO4) and the solvent was evaporated to give the crude product. The target compound (1.73 g, 5.58 mmol, 93% yield) was purified by silica gel fast column chromatography (eluent: hexane/ethyl acetate, 5:1). Thin layer chromatography (TLC) showed Rf = 0.16 (Expanding agent: hexane/ethyl acetate, 5:1, potassium permanganate solution showed color). Nuclear magnetic resonance hydrogen (1H-NMR, 500 MHz, CDCl3) and carbon (13C-NMR, 125 MHz, CDCl3) spectral data were consistent with the structure of the target compound. Mass spectrometry (MS) and high performance liquid chromatography-mass spectrometry (HRMS) data further confirmed the molecular weight and structure of the target compounds.
References
[1] Journal of the American Chemical Society, 2014, vol. 136, # 18, p. 6754 - 6762
[2] Tetrahedron, 2012, vol. 68, # 2, p. 697 - 704
[3] Organic letters, 2002, vol. 4, # 8, p. 1335 - 1338
[4] Organic Letters, 2010, vol. 12, # 22, p. 5306 - 5309
[5] Chemistry - A European Journal, 2016, vol. 22, # 47, p. 16912 - 16919
Boc-Thr-OBzl Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15350 | 60 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Wuxi Zhongkun Biochemical Technology Co., Ltd. | 0510-85629785 18013409632; | sales@reading-chemicals.com | China | 15165 | 58 |
| NINGBO INNO PHARMCHEM CO.,LTD. | 86-574-27787657 | info@dearchem.com | China | 4607 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Wuxi Asia Peptide Biotechnology Limited Company | 0510-83583050 13771062561 | willsun@peptide-search.com | China | 6713 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
View Lastest Price from Boc-Thr-OBzl manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-11 | Boc-Thr-Obzl
33662-26-9
|
1kg | 98% | 1T+ | Sichuan HongRi Pharma-Tech Co.,Ltd | ||
 |
2024-08-15 | BOC-THR-OBZL
33662-26-9
|
$1.00 | 1KG | 99% | 20T | Shaanxi Dideu Medichem Co. Ltd | |
 |
2020-01-10 | BOC-THR-OBZL
33662-26-9
|
$1.00 | 1KG | 98% | 200kgs | Career Henan Chemical Co |
-
- Boc-Thr-Obzl
33662-26-9
- 98%
- Sichuan HongRi Pharma-Tech Co.,Ltd
-
- BOC-THR-OBZL
33662-26-9
- $1.00
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- BOC-THR-OBZL
33662-26-9
- $1.00
- 98%
- Career Henan Chemical Co
