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Methyl N-(tert-butoxycarbonyl)-L-threoninate

Methyl N-(tert-butoxycarbonyl)-L-threoninate Structure
Methyl N-(tert-butoxycarbonyl)-L-threoninate structure
CAS No.
79479-07-5
Chemical Name:
Methyl N-(tert-butoxycarbonyl)-L-threoninate
Synonyms
Boc-L-Thr-OMe;Boc-Thr-OMe-OH;N-BOC-L-threonine methylester;(Tert-Butoxy)Carbonyl Thr-OMe;N-Boc-L-threonine methyl ester, 95%;N-Boc-L-threonine methyl ester, 97.5%;Boc-L-threonine methyl ester≥ 98% (HPLC);N-(TERT-BUTOXYCARBONYL)-L-THREONINE MET&;Methyl N-(tert-butoxycarbonyl)-L-threoninate;Methyl N-(tert-butoxycarbonyl)-L-threoninate USP/EP/BP
CBNumber:
CB3504231
Molecular Formula:
C10H19NO5
Molecular Weight:
233.26
MDL Number:
MFCD00270479
MOL File:
79479-07-5.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 02:37:24
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Methyl N-(tert-butoxycarbonyl)-L-threoninate Properties

Boiling point 206 °C(lit.)
Density 1.123±0.06 g/cm3(Predicted)
refractive index n20/D 1.45(lit.)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Chloroform (Sparingly), Dichloromethane (Sparingly), DMF (Sparingly)
form Viscous Liquid
pka 11.00±0.46(Predicted)
color Yellow
Water Solubility Slightly soluble in water.
Major Application peptide synthesis
InChI 1S/C10H19NO5/c1-6(12)7(8(13)15-5)11-9(14)16-10(2,3)4/h6-7,12H,1-5H3,(H,11,14)/t6-,7+/m1/s1
InChIKey MZMWAPNVRMDIPS-RQJHMYQMSA-N
SMILES COC(=O)[C@@H](NC(=O)OC(C)(C)C)[C@@H](C)O
UNSPSC Code 12352200
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Skull and Crossbones (GHS06)
GHS06
Signal word  Warning
Hazard statements  H302+H332-H311-H315-H319
Precautionary statements  P261-P264b-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P330-P361-P405-P501c
WGK Germany  3
HS Code  29241990
Storage Class 10 - Combustible liquids
NFPA 704
1
0 0

Methyl N-(tert-butoxycarbonyl)-L-threoninate price More Price(63)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 465658 N-(tert-Butoxycarbonyl)-L-threonine methyl ester 95% 79479-07-5 10g $165 2022-05-15 Buy
Usbiological 265269 Boc-L-threonine methyl ester Asreported 79479-07-5 5g $376 2026-06-03 Buy
Usbiological 265269 Boc-L-threonine methyl ester Asreported 79479-07-5 10g $523 2026-06-03 Buy
Usbiological 265269 Boc-L-threonine methyl ester Asreported 79479-07-5 25g $844 2026-06-03 Buy
Usbiological 265269 Boc-L-threonine methyl ester Asreported 79479-07-5 50g $1187 2026-06-03 Buy
Product number Packaging Price Buy
465658 10g $165 Buy
265269 5g $376 Buy
265269 10g $523 Buy
265269 25g $844 Buy
265269 50g $1187 Buy

Methyl N-(tert-butoxycarbonyl)-L-threoninate Chemical Properties,Uses,Production

Chemical Properties

Light yellow transparent oil

Uses

N-Boc-L-threonine methyl ester is used as pharmaceutical intermediates and chemical intermediate.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

Boc-L-Threonine

2592-18-9

Dimethyl sulfate

77-78-1

D-Allothreonine, N-[(1,1-dimethylethoxy)carbonyl]-, methyl ester

60538-19-4

The general procedure for the synthesis of Boc-D-alanine methyl ester from (2S,3R)-2-((tert-butoxycarbonyl)amino)-3-hydroxybutanoic acid and dimethyl sulfate was as follows: 1) Synthesis of N-Boc-L-threonine methyl ester: Potassium carbonate (34.7 g, 250 mmol) and dimethyl sulfate (29.3 g, 232 mmol) were sequentially added to a solution of N-Boc-L-threonine (50.0 g, 213 mmol) in acetone (250 mL). The reaction mixture was heated to reflux for 1 h and subsequently cooled to room temperature in air. Insoluble solids were removed by filtration and the filtrate was concentrated under reduced pressure to remove the solvent to afford N-tert-butoxycarbonyl-L-threonine methyl ester as a colorless oil (54.6 g, 100% yield). The product was characterized by 1H-NMR (300 MHz, DMSO-d6): δ 1.26 (3H, d, J = 6.42 Hz), 1.46 (9H, s), 2.02 (1H, d, J = 5.14 Hz), 3.78 (3H, s), 4.28 (1H, m), 5.29 (1H, m). Mass spectra (FAB) showed molecular ion peak m/z: 234 ([M + H]+).

References

[1] Patent: EP1621537, 2006, A1. Location in patent: Page/Page column 25
[2] Patent: CN108003048, 2018, A. Location in patent: Paragraph 0013

Methyl N-(tert-butoxycarbonyl)-L-threoninate Preparation Products And Raw materials

Raw materials

Boc-L-Threonine Dimethyl sulfate Potassium carbonate Acetone

Preparation Products

Methyl N-(tert-butoxycarbonyl)-L-threoninate Suppliers

Global( 119)Suppliers
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Accela ChemBio Co.,Ltd. 021-50795510 4000665055 marketing@accelachem.com China 10972 64
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
ChemPep, Inc. +1 (888) 615-9178 / (561) 791-8787 service@chempep.com United States 2138 57
Shanghai civi chemical technology co.,Ltd 86-21-34053660 sale@labgogo.com China 9853 52
Beijing HuaMeiHuLiBiological Chemical 010-56205725 waley188@sohu.com China 12323 58
Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd. +86-28-85122536 85324413 market@astatech.cn China 8016 55
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Alfa Aesar 84
Energy Chemical 61
Accela ChemBio Co.,Ltd. 64
Shanghai Hanhong Scientific Co.,Ltd. 64
ChemPep, Inc. 57
Shanghai civi chemical technology co.,Ltd 52
Beijing HuaMeiHuLiBiological Chemical 58
Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd. 55
Bide Pharmatech Ltd. 60

View Lastest Price from Methyl N-(tert-butoxycarbonyl)-L-threoninate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Boc-Thr-OMe pictures 2026-09-11 Boc-Thr-OMe
79479-07-5
 1kg 98% 1T Sichuan HongRi Pharma-Tech Co.,Ltd
Methyl N-(tert-butoxycarbonyl)-L-threoninate pictures 2020-01-09 Methyl N-(tert-butoxycarbonyl)-L-threoninate
79479-07-5
 $1.00 1KG 99% 100KG Career Henan Chemical Co
Boc-Thr-OMe pictures 2020-01-06 Boc-Thr-OMe
79479-07-5
 $1.00 1g 98% 100KG Sichuan Jiaying Lai Technology Co.,LTD
  • Boc-Thr-OMe pictures
  • Boc-Thr-OMe
    79479-07-5
  • 98%
  • Sichuan HongRi Pharma-Tech Co.,Ltd
  • Boc-Thr-OMe pictures
  • Boc-Thr-OMe
    79479-07-5
  • $1.00
  • 98%
  • Sichuan Jiaying Lai Technology Co.,LTD

Methyl N-(tert-butoxycarbonyl)-L-threoninate Spectrum

Methyl N-(tert-butoxycarbonyl)-L-threoninate(79479-07-5)1HNMR

79479-07-5(Methyl N-(tert-butoxycarbonyl)-L-threoninate)Related Search:

BOC-DL-PRO-OH N-Boc-4-oxo-L-Proline methyl ester Boc-Tyr-OtBu Boc-D-Ser(tBu)-OH Boc-Trp(Boc)-OH
Boc-L-serine methyl ester Boc-Hyp-OH 1-BOC-D-PYROGLUTAMIC ACID ETHYL ESTER Boc-D-Valine Methyl dihydrojasmonate
Methyl salicylate BOC-SER(TOS)-OCH3 Boc-guanidine Boc-D-Phe-OSu BOC-D-TYR(TBU)-OH
Boc-L-Threonine BOC-L-THR(BZL)-O-CH2-PHI-CH2-COOH DCHA Methyl N-(tert-butoxycarbonyl)-L-threoninate

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methyl (2S,3R)-2-{[(tert-butoxy)carbonyl]amino}-3-hydroxybutanoate Methyl N-(tert-butoxycarbonyl)-L-threoninate N-(TERT-BUTOXYCARBONYL)-L-THREONINE MET& N-BOC-L-threonine methylester (2S,3R)-methyl 2-(tert-butoxycarbonylamino)-3-hydroxybutanoate Boc-L-Thr-OMe Boc-L-threonine methyl ester≥ 98% (HPLC) (Tert-Butoxy)Carbonyl Thr-OMe N-Boc-L-threonine methyl ester, 97.5% (2S, 3S)-2-Tert-butoxycarbonylaMino-3-hydroxy-butyric acid Methyl ester Boc-Thr-OMe L-Threonine, N-[(1,1-dimethylethoxy)carbonyl]-, methyl ester Methyl N-(tert-butoxycarbonyl)-L-threoninate USP/EP/BP Boc-Thr-OMe-OH N-(tert-Butoxycarbonyl)-L-threonine methyl ester N-Boc-L-threonine methyl ester, 95% (2S,3R)-Methyl 2-((tert-butoxycarbonyl)amino)-3-hydroxybutanoate - [M89142] 79479-07-5 CH3CHOHCHNHCO2CCH33CO2CH3 Threonine Amino Acid Derivatives Peptide Synthesis