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Methyl N-(tert-butoxycarbonyl)-L-threoninate

Methyl N-(tert-butoxycarbonyl)-L-threoninate structure

CAS No.: 79479-07-5

Chemical Name:: Methyl N-(tert-butoxycarbonyl)-L-threoninate

Synonyms: Boc-L-Thr-OMe;Boc-Thr-OMe-OH;N-BOC-L-threonine methylester;(Tert-Butoxy)Carbonyl Thr-OMe;N-Boc-L-threonine methyl ester, 95%;N-Boc-L-threonine methyl ester, 97.5%;Boc-L-threonine methyl ester≥ 98% (HPLC);N-(TERT-BUTOXYCARBONYL)-L-THREONINE MET&;Methyl N-(tert-butoxycarbonyl)-L-threoninate;Methyl N-(tert-butoxycarbonyl)-L-threoninate USP/EP/BP

CBNumber:: CB3504231

Molecular Formula:: C10H19NO5

Molecular Weight:: 233.26

MDL Number:: MFCD00270479

MOL File:: 79479-07-5.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 02:37:24

Product description	Number	Pack Size	Price
N-(tert-Butoxycarbonyl)-L-threonine methyl ester 95%	465658	10g	$165
Boc-L-threonine methyl ester Asreported	265269	5g	$376
Boc-L-threonine methyl ester Asreported	265269	10g	$523
Boc-L-threonine methyl ester Asreported	265269	25g	$844
Boc-L-threonine methyl ester Asreported	265269	50g	$1187
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Methyl N-(tert-butoxycarbonyl)-L-threoninate Properties

Boiling point	206 °C(lit.)
Density	1.123±0.06 g/cm3(Predicted)
refractive index	n20/D 1.45(lit.)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Chloroform (Sparingly), Dichloromethane (Sparingly), DMF (Sparingly)
form	Viscous Liquid
pka	11.00±0.46(Predicted)
color	Yellow
Water Solubility	Slightly soluble in water.
Major Application	peptide synthesis
InChI	1S/C10H19NO5/c1-6(12)7(8(13)15-5)11-9(14)16-10(2,3)4/h6-7,12H,1-5H3,(H,11,14)/t6-,7+/m1/s1
InChIKey	MZMWAPNVRMDIPS-RQJHMYQMSA-N
SMILES	COC(=O)[C@@H](NC(=O)OC(C)(C)C)[C@@H](C)O
UNSPSC Code	12352200
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06

Signal word

Warning

Hazard statements

H302+H332-H311-H315-H319

Precautionary statements

P261-P264b-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P330-P361-P405-P501c

WGK Germany

HS Code

29241990

Storage Class

10 - Combustible liquids

NFPA 704

	1
0		0

Methyl N-(tert-butoxycarbonyl)-L-threoninate price More Price(73)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	465658	N-(tert-Butoxycarbonyl)-L-threonine methyl ester 95%	79479-07-5	10g	$165	2022-05-15	Buy
Usbiological	265269	Boc-L-threonine methyl ester Asreported	79479-07-5	5g	$376	2026-06-03	Buy
Usbiological	265269	Boc-L-threonine methyl ester Asreported	79479-07-5	10g	$523	2026-06-03	Buy
Usbiological	265269	Boc-L-threonine methyl ester Asreported	79479-07-5	25g	$844	2026-06-03	Buy
Usbiological	265269	Boc-L-threonine methyl ester Asreported	79479-07-5	50g	$1187	2026-06-03	Buy

Product number	Packaging	Price	Buy
465658	10g	$165	Buy
265269	5g	$376	Buy
265269	10g	$523	Buy
265269	25g	$844	Buy
265269	50g	$1187	Buy

Methyl N-(tert-butoxycarbonyl)-L-threoninate Chemical Properties,Uses,Production

Chemical Properties

Light yellow transparent oil

Uses

N-Boc-L-threonine methyl ester is used as pharmaceutical intermediates and chemical intermediate.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

2592-18-9

77-78-1

D-Allothreonine, N-[(1,1-dimethylethoxy)carbonyl]-, methyl ester

60538-19-4

The general procedure for the synthesis of Boc-D-alanine methyl ester from (2S,3R)-2-((tert-butoxycarbonyl)amino)-3-hydroxybutanoic acid and dimethyl sulfate was as follows: 1) Synthesis of N-Boc-L-threonine methyl ester: Potassium carbonate (34.7 g, 250 mmol) and dimethyl sulfate (29.3 g, 232 mmol) were sequentially added to a solution of N-Boc-L-threonine (50.0 g, 213 mmol) in acetone (250 mL). The reaction mixture was heated to reflux for 1 h and subsequently cooled to room temperature in air. Insoluble solids were removed by filtration and the filtrate was concentrated under reduced pressure to remove the solvent to afford N-tert-butoxycarbonyl-L-threonine methyl ester as a colorless oil (54.6 g, 100% yield). The product was characterized by 1H-NMR (300 MHz, DMSO-d6): δ 1.26 (3H, d, J = 6.42 Hz), 1.46 (9H, s), 2.02 (1H, d, J = 5.14 Hz), 3.78 (3H, s), 4.28 (1H, m), 5.29 (1H, m). Mass spectra (FAB) showed molecular ion peak m/z: 234 ([M + H]+).

References

[1] Patent: EP1621537, 2006, A1. Location in patent: Page/Page column 25
[2] Patent: CN108003048, 2018, A. Location in patent: Paragraph 0013

Methyl N-(tert-butoxycarbonyl)-L-threoninate Preparation Products And Raw materials

Raw materials

Boc-L-Threonine Dimethyl sulfate Potassium carbonate Acetone

Preparation Products

Methyl N-(tert-butoxycarbonyl)-L-threoninate Suppliers

Global( 116)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Sichuan HongRi Pharma-Tech Co.,Ltd	+8618382028708	ni@enlaibio.com	China	1103	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Sichuan Jiaying Lai Technology Co.,LTD	18716376478	ycling@enlaibio.com	CHINA	302	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29792	58
GL Biochem(Binhai) Ltd.	+86-021-61263370 +8615301650015	wuqiuyan@glschina.com	China	2975	58
Dideu Industries Group Limited	+86-86-15536356810 +8617392712697	1022@dideu.com	China	29068	58
Finetech Industry Limited	+86-27-8746-5837 +8619945049750	info@finetechnology-ind.com	China	9539	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 +8617705817739	info@dycnchem.com	China	52704	58
Nextpeptide Inc	+86-0571-81612335 +8613336028439	sales@nextpeptide.com	China	19908	58
Labnetwork lnc.	+86-27-50766799 +8618062016861	contact@labnetwork.com	China	19987	58

Supplier	Advantage
Sichuan HongRi Pharma-Tech Co.,Ltd	58
ATK CHEMICAL COMPANY LIMITED	60
Sichuan Jiaying Lai Technology Co.,LTD	58
career henan chemical co	58
GL Biochem(Binhai) Ltd.	58
Dideu Industries Group Limited	58
Finetech Industry Limited	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
Nextpeptide Inc	58
Labnetwork lnc.	58

View Lastest Price from Methyl N-(tert-butoxycarbonyl)-L-threoninate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-07-15	Boc-Thr-OMe 79479-07-5		1kg	98%	1T	Sichuan HongRi Pharma-Tech Co.,Ltd
2020-01-09	Methyl N-(tert-butoxycarbonyl)-L-threoninate 79479-07-5	$1.00	1KG	99%	100KG	Career Henan Chemical Co
2020-01-06	Boc-Thr-OMe 79479-07-5	$1.00	1g	98%	100KG	Sichuan Jiaying Lai Technology Co.,LTD

Boc-Thr-OMe
79479-07-5
98%
Sichuan HongRi Pharma-Tech Co.,Ltd

Methyl N-(tert-butoxycarbonyl)-L-threoninate
79479-07-5
$1.00
99%
Career Henan Chemical Co

Boc-Thr-OMe
79479-07-5
$1.00
98%
Sichuan Jiaying Lai Technology Co.,LTD

Methyl N-(tert-butoxycarbonyl)-L-threoninate Spectrum

Methyl N-(tert-butoxycarbonyl)-L-threoninate(79479-07-5)¹HNMR

79479-07-5(Methyl N-(tert-butoxycarbonyl)-L-threoninate)Related Search:

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Boc-Hyp-OH 1-BOC-D-PYROGLUTAMIC ACID ETHYL ESTER Boc-D-Valine BOC-D-PHE-OSU Methyl dihydrojasmonate

Methyl salicylate BOC-SER(TOS)-OCH3 Boc-L-serine methyl ester BOC-GUANIDINE BOC-D-TYR(TBU)-OH

Boc-L-Threonine BOC-L-THR(BZL)-O-CH2-PHI-CH2-COOH DCHA Methyl N-(tert-butoxycarbonyl)-L-threoninate

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methyl (2S,3R)-2-{[(tert-butoxy)carbonyl]amino}-3-hydroxybutanoate Methyl N-(tert-butoxycarbonyl)-L-threoninate N-(TERT-BUTOXYCARBONYL)-L-THREONINE MET& N-BOC-L-threonine methylester (2S,3R)-methyl 2-(tert-butoxycarbonylamino)-3-hydroxybutanoate Boc-L-Thr-OMe Boc-L-threonine methyl ester≥ 98% (HPLC) (Tert-Butoxy)Carbonyl Thr-OMe N-Boc-L-threonine methyl ester, 97.5% (2S, 3S)-2-Tert-butoxycarbonylaMino-3-hydroxy-butyric acid Methyl ester Boc-Thr-OMe L-Threonine, N-[(1,1-dimethylethoxy)carbonyl]-, methyl ester Methyl N-(tert-butoxycarbonyl)-L-threoninate USP/EP/BP Boc-Thr-OMe-OH N-(tert-Butoxycarbonyl)-L-threonine methyl ester N-Boc-L-threonine methyl ester, 95% (2S,3R)-Methyl 2-((tert-butoxycarbonyl)amino)-3-hydroxybutanoate - [M89142] 79479-07-5 CH3CHOHCHNHCO2CCH33CO2CH3 Threonine Amino Acid Derivatives Peptide Synthesis