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Cbz-L-Threonine benzyl ester

Cbz-L-Threonine benzyl ester Structure
Cbz-L-Threonine benzyl ester structure
CAS No.
16597-50-5
Chemical Name:
Cbz-L-Threonine benzyl ester
Synonyms
N-Carbobenzoxy-L-threonine Benzyl Ester;Z-THR-OBZL;CBZ-THR-OBZL;Z-L-Thr-OBzl;Cbz-L-Thr-OBzl;Cbz-Thr-Obzl-OH;Z-THREONINE-OBZL;CBZ-L-THR BENZYL ESTER;Z-L-THREONINE BENZYL ESTER;Cbz-L-Threonineα-benzylester
CBNumber:
CB1769692
Molecular Formula:
C19H21NO5
Molecular Weight:
343.37
MDL Number:
MFCD00077041
MOL File:
16597-50-5.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-27 23:44:55
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Cbz-L-Threonine benzyl ester Properties

Melting point 78-82°C
Boiling point 536.8±50.0 °C(Predicted)
Density 1.228±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,2-8°C
solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form powder to crystal
pka 10.76±0.46(Predicted)
color White to Almost white
optical activity Consistent with structure
CAS DataBase Reference 16597-50-5(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P301+P312-P302+P352-P304+P340-P305+P351+P338
Safety Statements  24/25
HS Code  29224999
NFPA 704
1
0 0

Cbz-L-Threonine benzyl ester price More Price(39)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical C2285 N-Carbobenzoxy-L-threonine Benzyl Ester >98.0%(HPLC)(N) 16597-50-5 5g $103 2026-04-30 Buy
Usbiological 291108 Z-L-threonine alpha-benzyl ester Asreported 16597-50-5 5g $360 2026-06-03 Buy
Usbiological 291108 Z-L-threonine alpha-benzyl ester Asreported 16597-50-5 10g $498 2026-06-03 Buy
Usbiological 291108 Z-L-threonine alpha-benzyl ester Asreported 16597-50-5 25g $811 2026-06-03 Buy
Usbiological 291108 Z-L-threonine alpha-benzyl ester Asreported 16597-50-5 50g $1133 2026-06-03 Buy
Product number Packaging Price Buy
C2285 5g $103 Buy
291108 5g $360 Buy
291108 10g $498 Buy
291108 25g $811 Buy
291108 50g $1133 Buy

Cbz-L-Threonine benzyl ester Chemical Properties, Uses, Production

Chemical Properties

White powder

Synthesis

N-Cbz-L-Threonine

19728-63-3

Benzyl bromide

100-39-0

L-Allothreonine, N-[(phenylmethoxy)carbonyl]-, phenylmethyl ester

84500-41-4

General procedure for the synthesis of compounds (CAS: 84500-41-4) from (2S,3R)-2-(((benzyloxy)carbonyl)amino)-3-hydroxybutanoic acid and benzyl bromide: (2S,3R)-2- benzyloxycarbonylamino-3-hydroxybutanoic acid (1.0 g, 4.0 mmol) was dissolved in a mixture of N,N-dimethylformamide (DMF, 15.0 mL) and deionized water (5.0 mL) in a mixed solvent, cesium carbonate (644.5 mg, 2.0 mmol) was added, and the reaction was stirred for 30 min at room temperature. After the reaction was completed, the reaction solution was concentrated and the residual water was removed by azeotropy with toluene (3 × 10 mL). Subsequently, a solution of benzyl bromide (0.71 mL, 5.9 mmol) in DMF (10.0 mL) was added to the dried residue and the reaction was continued for 24 hours. At the end of the reaction, the reaction was quenched by the addition of water (15 mL) and extracted with ethyl acetate (2 x 30 mL). The organic phases were combined, dried over anhydrous sodium sulfate, filtered and concentrated. The crude product was purified by fast column chromatography with ethyl acetate/hexane (1:3, v/v) as eluent to give the target compound (1.149 g, 84% yield) as a white powder. The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3), 13C NMR (125 MHz, CDCl3) and LC-ESI-MS: 1H NMR (400 MHz, CDCl3) δ 7.26-6.35 (m, 10H), 5.60 (d, 1H, J = 8.7 Hz), 5.17-5.24 (m, 2H) 5.13 (s, 2H), 4.37-4.39 (m, 2H), 1.97 (br, 1H), 1.63 (br, 1H), 1.23 (d, 1H, J = 6.3 Hz); 13C NMR (125 MHz, CDCl3) δ 171.2, 156.9, 136.2, 135.3, 128.6, 128.5, 128.5 128.5, 128.2, 128.0, 68.0, 67.4, 67.2, 59.5, 19.9; LC-ESI-MS [M + H]+ C19H21NO5 Calculated value 344.14, measured value 344.03.

References

[1] Tetrahedron Letters, 1968, p. 6323 - 6326
[2] Tetrahedron, 2018, vol. 74, # 23, p. 2891 - 2903

Cbz-L-Threonine benzyl ester Preparation Products And Raw materials

Raw materials

N-Cbz-L-Threonine Benzyl bromide N,N-Dimethylformamide Cesium carbonate

Preparation Products

Cbz-L-Threonine benzyl ester Suppliers

Global Suppliers ( 151)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
GL Biochem (Shanghai) Ltd 21-61263452 13641803416 ymbetter@glbiochem.com China 9981 64
Shanghai Longsheng chemical Co.,Ltd. 58099637 13585536065 sales@shlschem.com China 9880 59
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Chemsky (shanghai) International Co.,Ltd 021-50135380 shchemsky@sina.com China 15350 60
Shandong Xiya Chemical Co., Ltd 13355009207 13355009207 3007715519@qq.com China 18722 57
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61
GL Biochem (Shanghai) Ltd 64
Shanghai Longsheng chemical Co.,Ltd. 59
Shanghai Hanhong Scientific Co.,Ltd. 64
Chemsky (shanghai) International Co.,Ltd 60
Shandong Xiya Chemical Co., Ltd 57

View Latest Price from Cbz-L-Threonine benzyl ester manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Cbz-Thr-Obzl pictures 2026-09-17 Cbz-Thr-Obzl
16597-50-5
 1kg 98% 1T+ Sichuan HongRi Pharma-Tech Co.,Ltd
Cbz-L-Threonine benzyl ester pictures 2021-07-13 Cbz-L-Threonine benzyl ester
16597-50-5
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd
Cbz-L-Threonine benzyl ester pictures 2021-07-10 Cbz-L-Threonine benzyl ester
16597-50-5
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd

16597-50-5 (Cbz-L-Threonine benzyl ester) Related Search:

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(2S,3R)-benzyl 2-(benzyloxycarbonylamino)-3-hydroxybutanoate Z-L-threonine beta-benzyl ester N-Cbz-L-threonine Benzyl Ester Z-Thr-OBzl Cbz-L-Threoninea benzyl ester Cbz-L-Thr-OBzl Z-L-threonine α-benzyl ester≥ 98% (HPLC) N-BENZYLOXYCARBONYL-L-THREONINE BENZYL ESTER N-ALPHA-CARBOBENZOXY-L-THREONINE BENZYL ESTER N-CBZ-L-THREONINE BENZYL ESTER Z-L-THREONINE BENZYL ESTER Z-L-THREONINE ALPHA-BENZYL ESTER Z-THREONINE-OBZL Z-THR-OBZL CBZ-L-THR BENZYL ESTER CBZ-THR-OBZL BENZYLOXYCARBONYL-L-THREONINE BENZYL ESTER Cbz-L-Threonineα-benzylester N-alpha-Benzyloxycarbonyl-L-threonine benzyl ester Z-L-Thr-OBzl N-Benzyloxycarbonyl-L-threonine benzyl ester, 98%, Z-amino acids benzyl (2S,3R)-2-{[(benzyloxy)carbonyl]amino}-3-hydroxybutanoate N-Carbobenzoxy-L-threonine Benzyl Ester > L-Threonine, N-[(phenylmethoxy)carbonyl]-, phenylmethyl ester Cbz-L-Threonine benzyl ester USP/EP/BP Z-L-threonine α-benzyl ester Cbz-Thr-Obzl-OH Cbz-L-Threonine benzyl ester N-Carbobenzoxy-L-threonine Benzyl Ester 16597-50-5 Amino Acid Derivatives Z-Amino Acids and Derivatives