cis-Trimethoxy stilbene
- CAS No.
- 94608-23-8
- Chemical Name:
- cis-Trimethoxy stilbene
- Synonyms
- cis-Trimethoxy stilbene;CIS-TRISMETHOXY RESVERATROL;(Z)-3,5,4'-Trimethoxystilbene;CIS-TRIMETHOXY STILBENE USP/EP/BP;Resveratrol Trimethyl Ether cis-Isomer;cis-trismethoxy Resveratrol, 10 mM in DMSO;1,2,3-trimethoxy-4-(2-phenylethenyl)benzene;cis-trismethoxy Resveratrol (Solution in Ethanol);Resveratrol Impurity 27 (cis-trismethoxy Resveratrol);(Z)-1-(3,5-dimethoxyphenyl)-2-(4-methoxyphenyl)ethene
- CBNumber:
- CB12468643
- Molecular Formula:
- C17H18O3
- Molecular Weight:
- 270.32
- MDL Number:
- MFCD11977725
- MOL File:
- 94608-23-8.mol
- MSDS File:
- SDS
| Melting point | 55-57 °C |
|---|---|
| Boiling point | 423.8±35.0 °C(Predicted) |
| Density | 1.104±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | ≤50mg/ml in DMSO;50mg/ml in dimethyl formamide |
| form | solution in ethanol. |
| color | Colorless to light yellow |
| CAS DataBase Reference | 94608-23-8 |
cis-Trimethoxy stilbene price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 13199 | cis-trismethoxy Resveratrol ≥98% | 94608-23-8 | 10mg | $19 | 2026-04-30 | Buy |
| Cayman Chemical | 13199 | cis-trismethoxy Resveratrol ≥98% | 94608-23-8 | 50mg | $74 | 2026-04-30 | Buy |
| Cayman Chemical | 13199 | cis-trismethoxy Resveratrol ≥98% | 94608-23-8 | 100mg | $130 | 2026-04-30 | Buy |
| Cayman Chemical | 13199 | cis-trismethoxy Resveratrol ≥98% | 94608-23-8 | 500mg | $561 | 2026-04-30 | Buy |
| TRC | TRC-R150133-5MG | cis-trismethoxy Resveratrol (Solution in Ethanol) | 94608-23-8 | 5mg | $70 | 2026-06-03 | Buy |
cis-Trimethoxy stilbene Chemical Properties, Uses, Production
Description
Resveratrol is a potent antioxidant found in grapes and red wine that also has anti-
Uses
Resveratrol is a potent antioxidant found in grapes and red wine that also has anti-proliferative, anti-neoplastic and anti-angiogenic activities. In addition, resveratrol activates sirtuins and, in yeast, extends lifespan. cis-trismethoxy Resveratrol is a potent anti-mitotic drug that is 100-fold more active than resveratrol at inhibiting the growth of human colon cancer Caco-2 cells. It inhibits tubulin polymerization in a dose-dependent manner (IC50 = 4 μM) and inhibits enzymes involved in the synthesis of the polyamines, putrescine, and spermidine. trans-trismethoxy Resveratrol has superior pharmacokinetic characteristics when compared with resveratrol, including greater plasma exposure, longer elimination half-life, and lower clearance.
Uses
cis-trismethoxy Resveratrol is a potent antioxidant found in grapes and red wine. Also, it is a resveratrol analog with increased antiproliferative activity towards a number of cancer cell lines.
in vitro
cis-trismethoxy resveratrol at 0.3 microm could exert a 80% growth inhibition of human colon cancer caco-2 cells and arrest growth completely at 0.4 microm. the cis conformation of cis-trismethoxy resveratrol was also 100-fold more potent than the trans isomer. cis-trismethoxy resveratrol was able to cause cell cycle arrest at the g2/m phase transition and inhibit tubulin polymerization dose-dependently, leading to the depletion of the polyamines, putrescine and spermidine. in addition, cis-trismethoxy resveratrol inhibited partially colchicine binding to its binding site on tubulin [1].
in vivo
previous study found that from the angle of pharmacokinetics, cis-trismethoxy resveratrol appeared to be a superior analog of resveratrol since it was orally available and showed greater plasma exposure, longer elimination half-life and lower clearance. due to the superior pharmacokinetic characteristics of cis-trismethoxy resveratrol had, its potentials as a preventive or therapeutic agent in resveratrol-effective diseases would be considered [2].
IC 50
4 microm for tubulin polymerization
References
[1] schneider, y. ,chabert, p.,stutzmann, j., et al. resveratrol analog (z)-3,5,4'-trimethoxystilbene is a potent anti-mitotic drug inhibiting tubulin polymerization. international journal of cancer 107, 189-196 (2003).
[2] lin, h. s. and ho, p.c. a rapid hplc method for the quantification of 3,5,4'-trimethoxy-trans-stilbene (tms) in rat plasma and its application in pharmacokinetic study. journal of pharmaceutical & biomedical analysis 49, 387-392 (2009).
cis-Trimethoxy stilbene Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| XiaoGan ShenYuan ChemPharm co,ltd | 15527621225; 15527621225 | 1791901229@qq.com | China | 6743 | 52 |
| T&W GROUP | 021-61551611 13296011611 | contact@trustwe.com | China | 9884 | 58 |
| Shanghai T&W Pharmaceutical Co., Ltd. | +86 21 61551611 | China | 9874 | 58 | |
| Finetech Industry Limited | 027-87465837 19945049750 | sales@finetechnology-ind.com | China | 9331 | 58 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9909 | 65 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Jiangsu aikang biomedical research and development co., LTD | 025-58859352 17714375163 | qzhang@aikonchem.com | China | 15525 | 58 |
| Alfa Chemistry | +1-5166625404; | Info@alfa-chemistry.com | United States | 20000 | 58 |
View Latest Price from cis-Trimethoxy stilbene manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-15 | cis-trismethoxy Resveratrol
94608-23-8
|
$54.00-110.00 | 99.88% | 10g | TargetMol Chemicals Inc. |
-
- cis-trismethoxy Resveratrol
94608-23-8
- $54.00-110.00
- 99.88%
- TargetMol Chemicals Inc.
