trans/cis Resveratrol-D4
- CAS No.
- 1089051-56-8
- Chemical Name:
- trans/cis Resveratrol-D4
- Synonyms
- trans/cis Resveratrol-D4;5-[(E)-2-(2,3,5,6-tetradeuterio-4-hydroxyphenyl)ethenyl]benzene-1,3-diol;Resveratrol D4Q: What is Resveratrol D4 Q: What is the CAS Number of Resveratrol D4 Q: What is the storage condition of Resveratrol D4 Q: What are the applications of Resveratrol D4
- CBNumber:
- CB32647480
- Molecular Formula:
- C14H8D4O3
- Molecular Weight:
- 232.27
- MDL Number:
- MOL File:
- 1089051-56-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| trans-Resveratrol-d4 ≥99%deuteratedforms(d1- |
13130 | 100μg | $54 |
| trans-Resveratrol-d4 ≥99%deuteratedforms(d1- |
13130 | 250μg | $127 |
| trans-Resveratrol-d4 ≥99%deuteratedforms(d1- |
13130 | 500μg | $238 |
| trans-Resveratrol-d4 ≥99%deuteratedforms(d1- |
13130 | 1mg | $418 |
| Resveratrol-d4 99.36% | CS-0085961 | 1mg | $770 |
| Boiling point | 449.115±14.00 °C(Press: 760.00 Torr)(predicted) |
|---|---|
| Density | 1.359±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) |
| storage temp. | Store at -20°C |
| solubility | DMF: >100 mg/ml,DMSO: >50mg/ml,Ethanol: >50mg/ml,PBS (pH 7.2): <100 μg/ml |
| form | Liquid |
| pka | 9.221±0.10(predicted) |
| color | Colorless to light yellow |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H350 | |||||||||
| Precautionary statements | P201-P202-P210-P233-P240-P241-P242-P243-P280-P303+P361+P353-P308+P313-P370+P378-P403+P235-P405-P501 | |||||||||
| NFPA 704 |
|
trans/cis Resveratrol-D4 price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 13130 | trans-Resveratrol-d4 ≥99%deuteratedforms(d1- |
1089051-56-8 | 100μg | $54 | 2026-04-30 | Buy |
| Cayman Chemical | 13130 | trans-Resveratrol-d4 ≥99%deuteratedforms(d1- |
1089051-56-8 | 250μg | $127 | 2026-04-30 | Buy |
| Cayman Chemical | 13130 | trans-Resveratrol-d4 ≥99%deuteratedforms(d1- |
1089051-56-8 | 500μg | $238 | 2026-04-30 | Buy |
| Cayman Chemical | 13130 | trans-Resveratrol-d4 ≥99%deuteratedforms(d1- |
1089051-56-8 | 1mg | $418 | 2026-04-30 | Buy |
| ChemScene | CS-0085961 | Resveratrol-d4 99.36% | 1089051-56-8 | 1mg | $770 | 2026-06-04 | Buy |
trans/cis Resveratrol-D4 Chemical Properties,Uses,Production
Description
trans-Resveratrol-d4 is intended for use as an internal standard for the quantification of trans-resveratrol by GC- or LC-MS. trans-Resveratrol is a polyphenolic phytoalexin found in a variety of plants, including grapes, that has anti-inflammatory, antioxidant, and anticancer activities. It inhibits the cyclooxygenase and hydroperoxidase activities of COX-1 (EC50s = 15 and 3.7 μM, respectively), but not COX-2 (EC50s = >100 μM and 85 μM, respectively). trans-Resveratrol (3 and 8 mg/kg) inhibits carrageenan-induced paw edema in mice. It inhibits free radical formation in HL-60 human promyelocytic leukemia cells induced by phorbol 12-myristate 13-acetate (TPA; ; EC50 = 27 μM). trans-Resveratrol (1-25 μmol) reduces both the incidence and number of tumors in a two-stage mouse model of skin cancer induced by TPA and 7,12-dimethyl-benz[a]anthracene (DMBA). trans-Resveratrol (200 μM) also activates sirtuin 1 (SIRT1) by 8-fold in vitro and inhibits a variety of targets including ERK1, JNK1, Src, PKCα, aromatase/CYP19, and DNA polymerases α and δ (IC50s = 37, 50, 20, <10, 25, 3.3, and 5 μM, respectively) in vitro and/or ex vivo. It prolongs lifespan in model organisms including C. elegans, D. melanogaster, and mice.
Uses
Resveratrol-d4 is labelled Resveratrol (R150000) which is a minor constituent of wine, correlated with serum lipid reduction and inhibition of platelet aggregation. Resveratrol is a specific inhibitor of COX-1, and it also inhibits the hydroperoxidase activity of COX-1. It has been shown to inhibit events associated with tumor initiation, promotion and progression.
References
[1] MEISHIANG JANG. Cancer Chemopreventive Activity of Resveratrol, a Natural Product Derived from Grapes[J]. Science, 1997, 275 5297. DOI: 10.1126/science.275.5297.218
[2] LUCIANO PIROLA Sara F. Resveratrol: one molecule, many targets.[J]. IUBMB Life, 2008, 60 5: 323-332. DOI: 10.1002/iub.47
[3] MARGIE T BORRA John M D Brian C Smith. Mechanism of human SIRT1 activation by resveratrol.[J]. The Journal of Biological Chemistry, 2005, 280 17: 17187-17195. DOI: 10.1074/jbc.m501250200
trans/cis Resveratrol-D4 Preparation Products And Raw materials
Raw materials
Preparation Products
trans/cis Resveratrol-D4 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Clearsynth Labs Limited | +91-22-26355700 | info@clearsynth.com | India | 9656 | 58 |
| Artis Biotech Co. Ltd. | 18108108965 18108108965 | sales@artisbio.com | China | 2469 | 58 |
| Guangzhou Dreampharm Biotechnology Co., Ltd. | 020-36607679; 13502246435 | 3008233746@qq.com | China | 9965 | 12 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| Guangzhou Younan Technology Co., Ltd | 020-82000279 18988941452 | YN_research@163.com | China | 2951 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44924 | 58 |
| CHINA ISOTOPE CO., LIMITED | 02151600108 13062666369 | info@isotopechem.com | China | 4719 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 17301488900 | judy.xia@synzest.com | China | 12577 | 58 |
| TLC Pharmaceutical Standards Ltd. | 18012923235 | chinasales04@tlcstandards.com.cn | China | 8143 | 58 |
