TPEN
- CAS No.
- 16858-02-9
- Chemical Name:
- TPEN
- Synonyms
- TPEN;TPEDA;CS-960;TPEN, >=98%;TPEN/CH63857;TPEN (TPEDA);TPEN, 10 mM in DMSO;TPEN ISO 9001：2015 REACH;TPEN, Metal ion chelator;TPEN - CAS 16858-02-9 - Calbiochem
- CBNumber:
- CB1249909
- Molecular Formula:
- C26H28N6
- Molecular Weight:
- 424.54
- MDL Number:
- MFCD00036918
- MOL File:
- 16858-02-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 110-112 °C |
|---|---|
| Boiling point | 530.56°C (rough estimate) |
| Density | 1.3893 (rough estimate) |
| refractive index | 1.4570 (estimate) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | Soluble in DMSO (up to 10 mg/ml). |
| pka | 5.19±0.12(Predicted) |
| form | Tan solid |
| color | Off-white or tan |
| BRN | 4211982 |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| InChI | InChI=1S/C26H28N6/c1-5-13-27-23(9-1)19-31(20-24-10-2-6-14-28-24)17-18-32(21-25-11-3-7-15-29-25)22-26-12-4-8-16-30-26/h1-16H,17-22H2 |
| InChIKey | CVRXLMUYFMERMJ-UHFFFAOYSA-N |
| SMILES | C(N(CC1=NC=CC=C1)CC1=NC=CC=C1)CN(CC1=NC=CC=C1)CC1=NC=CC=C1 |
| CAS DataBase Reference | 16858-02-9(CAS DataBase Reference) |
| FDA UNII | R9PTU1U29I |
| UNSPSC Code | 12352116 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 8-10-23 | |||||||||
| HS Code | 29333990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
TPEN price More Price(85)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | P4413 | N,N,N′,N′-Tetrakis(2-pyridylmethyl)ethylenediamine | 16858-02-9 | 50mg | $111 | 2026-04-30 | Buy |
| Sigma-Aldrich | P4413 | N,N,N′,N′-Tetrakis(2-pyridylmethyl)ethylenediamine | 16858-02-9 | 100mg | $163 | 2026-04-30 | Buy |
| Sigma-Aldrich | 616394 | TPEN - CAS 16858-02-9 - Calbiochem | 16858-02-9 | 100mg | $217 | 2026-04-30 | Buy |
| TCI Chemical | T1487 | N,N,N',N'-Tetrakis(2-pyridylmethyl)ethylenediamine >97.0%(T) | 16858-02-9 | 1g | $213 | 2026-04-30 | Buy |
| TCI Chemical | T1487 | N,N,N',N'-Tetrakis(2-pyridylmethyl)ethylenediamine >97.0%(T) | 16858-02-9 | 5g | $722 | 2026-04-30 | Buy |
TPEN Chemical Properties, Uses, Production
Description
TPEN (16858-02-9) is a cell permeable metal chelator. Frequently used to study effects of zinc depletion on cellular processes.1,2
Chemical Properties
Colourless Crystals
Uses
Membrane-permeable zinc chelator; decreased the intracellular level of zinc and induced apoptosis.
Definition
ChEBI: An N-substituted diamine that is ethylenediamine in which the four amino hydrogens are replaced by 2-pyridylmethyl groups.
reaction suitability
reagent type: chelator
Biochem/physiol Actions
N,N,N′,N′-Tetrakis(2-pyridylmethyl)ethylenediamine (TPEN) elicits pro-apoptotic effect in human acute promyelocytic NB4 cells by inhibiting nitric oxide signalling and Zn2+ signaling. In microglia pretreated with zinc, TPEN inhibits the interleukin 6 secretion and nitric oxide synthase (iNOS) mRNA expression. It induces damage on DNA structure by activating ATM (ataxia telangiectasia mutated) and ATR (ATM-Rad3-related) signaling in human colon cancer cells.
storage
Store at +4°C
References
[1] FABRICE CHIMIENTI . Role of cellular zinc in programmed cell death: temporal relationship between zinc depletion, activation of caspases, and cleavage of Sp family transcription factors1[J]. Biochemical pharmacology, 2001, 62 1: Pages 51-62. DOI:10.1016/s0006-2952(01)00624-4
[2] CATHERINE MÉPLAN Pierre H Marie Jeanne Richard. Metalloregulation of the tumor suppressor protein p53: zinc mediates the renaturation of p53 after exposure to metal chelators in vitro and in intact cells[J]. Oncogene, 2000, 19 46: 5227-5236. DOI:10.1038/sj.onc.1203907
TPEN Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Jingli Chemistry Co., Ltd. | 19072511635 15926669505 | jinglichemistry@126.com | China | 224 | 58 |
| Zhengzhou Alfachem Co., Ltd. | 0371-53765687 18937137882 | 3969243885@qq.com | China | 7734 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9407 | 55 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| VDM Biochemicals | 0330-2528181 | sales@vdmbio.com | United States | 510 | 64 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
View Latest Price from TPEN manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | TPEN
16858-02-9
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2026-04-21 | TPEN
16858-02-9
|
$38.00-80.00 | 99.94% | 10g | TargetMol Chemicals Inc. | ||
 |
2021-08-12 | TPEN
16858-02-9
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
