- TPEN
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- $38.00
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2026-04-21
- CAS:16858-02-9
- Purity: 99.94%
- Supply Ability: 10g
- TPEN
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- $1.10
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2025-11-18
- CAS:16858-02-9
- Min. Order: 1g
- Purity: 99.00%
- Supply Ability: 100 Tons Min
- TPEN
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- $15.00
-
2021-08-12
- CAS:16858-02-9
- Min. Order: 1KG
- Purity: 99%+ HPLC
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| Product Name: | TPEN | | Synonyms: | TETRAKIS-(2-PYRIDYLMETHYL)ETHYLENEDIAMINE;{2-[BIS(PYRIDIN-2-YLMETHYL)AMINO]ETHYL}BIS(PYRIDIN-2-YLMETHYL)AMINE;TPEN - CAS 16858-02-9 - Calbiochem;N,N,N',N'-tetrakis(2-pyridinylmethyl)-1,2-Ethanediamine;CS-960;TPEN;1,2-Ethanediamine, N,N,N',N'-tetrakis(2-pyridinylmethyl)-;1,2-Ethanediamine, N,N,N',N'-tetrakis(2-pyridinylmethyl)-, (oc-6-11)- | | CAS: | 16858-02-9 | | MF: | C26H28N6 | | MW: | 424.54 | | EINECS: | | | Product Categories: | Apoptosis;Aromatics;Chelating Agents & Ligands;Heterocycles;Inhibitors;Apoptosis Inducers | | Mol File: | 16858-02-9.mol |  |
| Melting point | 110-112 °C | | Boiling point | 530.56°C (rough estimate) | | density | 1.3893 (rough estimate) | | refractive index | 1.4570 (estimate) | | storage temp. | Sealed in dry,2-8°C | | solubility | Soluble in DMSO (up to 10 mg/ml). | | pka | 5.19±0.12(Predicted) | | form | Tan solid | | color | Off-white or tan | | BRN | 4211982 | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. | | InChI | InChI=1S/C26H28N6/c1-5-13-27-23(9-1)19-31(20-24-10-2-6-14-28-24)17-18-32(21-25-11-3-7-15-29-25)22-26-12-4-8-16-30-26/h1-16H,17-22H2 | | InChIKey | CVRXLMUYFMERMJ-UHFFFAOYSA-N | | SMILES | C(N(CC1=NC=CC=C1)CC1=NC=CC=C1)CN(CC1=NC=CC=C1)CC1=NC=CC=C1 | | CAS DataBase Reference | 16858-02-9(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | F | 8-10-23 | | HS Code | 29333990 | | Storage Class | 11 - Combustible Solids |
| Description | TPEN (16858-02-9) is a cell permeable metal chelator. Frequently used to study effects of zinc depletion on cellular processes.1,2 | | Chemical Properties | Colourless Crystals | | Uses | Membrane-permeable zinc chelator; decreased the intracellular level of zinc and induced apoptosis. | | Definition | ChEBI: An N-substituted diamine that is ethylenediamine in which the four amino hydrogens are replaced by 2-pyridylmethyl groups. | | reaction suitability | reagent type: chelator | | Biochem/physiol Actions | N,N,N′,N′-Tetrakis(2-pyridylmethyl)ethylenediamine (TPEN) elicits pro-apoptotic effect in human acute promyelocytic NB4 cells by inhibiting nitric oxide signalling and Zn2+ signaling. In microglia pretreated with zinc, TPEN inhibits the interleukin 6 secretion and nitric oxide synthase (iNOS) mRNA expression. It induces damage on DNA structure by activating ATM (ataxia telangiectasia mutated) and ATR (ATM-Rad3-related) signaling in human colon cancer cells. | | storage | Store at +4°C | | References | [1] FABRICE CHIMIENTI . Role of cellular zinc in programmed cell death: temporal relationship between zinc depletion, activation of caspases, and cleavage of Sp family transcription factors1[J]. Biochemical pharmacology, 2001, 62 1: Pages 51-62. DOI:10.1016/s0006-2952(01)00624-4
[2] CATHERINE MÉPLAN Pierre H Marie Jeanne Richard. Metalloregulation of the tumor suppressor protein p53: zinc mediates the renaturation of p53 after exposure to metal chelators in vitro and in intact cells[J]. Oncogene, 2000, 19 46: 5227-5236. DOI:10.1038/sj.onc.1203907 |
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