XRP44X
- CAS No.
- 729605-21-4
- Chemical Name:
- XRP44X
- Synonyms
- XRP44X;XRP44X, 10 mM in DMSO;Ras-Net (Elk-3) Pathway Inhibitor, XRP44X;Ras-Net (Elk-3) Pathway Inhibitor, XRP44X - CAS 729605-21-4 - Calbiochem;[4-(3-chlorophenyl)piperazin-1-yl]-(5-methyl-2-phenylpyrazol-3-yl)methanone;1-(3-Chlorophenyl)-4-[(3-methyl-1-phenyl-1H-pyrazol-5-yl)carbonyl]piperazine;Piperazine,1-(3-chlorophenyl)-4-[(3-methyl-1-phenyl-1H-pyrazol-5-yl)carbonyl]-;(4-(3-Chlorophenyl)piperazin-1-yl)(3-methyl-1-phenyl-1H-pyrazol-5-yl)methanone;[4-(3-Chlorophenyl)piperazin-1-yl](5-methyl-2-phenyl-2H-pyrazol-3-yl)methanone;[4-(3-Chlorophenyl)-1-piperazinyl](3-methyl-1-phenyl-1H-pyrazol-5-yl)-methanone
- CBNumber:
- CB12502879
- Molecular Formula:
- C21H21ClN4O
- Molecular Weight:
- 380.87
- MDL Number:
- MFCD12828749
- MOL File:
- 729605-21-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 136-140 0C |
|---|---|
| Boiling point | 591.1±50.0 °C(Predicted) |
| Density | 1.27±0.1 g/cm3(Predicted) |
| storage temp. | room temp |
| solubility | DMSO: ≥20mg/mL |
| pka | 1.79±0.20(Predicted) |
| form | White solid |
| color | white to off-white |
| InChI | 1S/C21H21ClN4O/c1-16-14-20(26(23-16)18-7-3-2-4-8-18)21(27)25-12-10-24(11-13-25)19-9-5-6-17(22)15-19/h2-9,14-15H,10-13H2,1H3 |
| InChIKey | NPHPNBGYPKBDDB-UHFFFAOYSA-N |
| UNSPSC Code | 12352200 |
XRP44X price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 257135 | XRP44X Asreported | 729605-21-4 | 10mg | $466 | 2026-06-03 | Buy |
| Usbiological | 257135 | XRP44X Asreported | 729605-21-4 | 50mg | $1281 | 2026-06-03 | Buy |
| TRC | TRC-X750960-50MG | XRP44X | 729605-21-4 | 50mg | $860 | 2026-06-03 | Buy |
| TRC | TRC-X750960-10MG | XRP44X | 729605-21-4 | 10mg | $193 | 2026-06-03 | Buy |
| TRC | TRC-X750960-100MG | XRP44X | 729605-21-4 | 100mg | $1528 | 2026-06-03 | Buy |
XRP44X Chemical Properties, Uses, Production
Uses
XRP44X, is a Ras-Net (Elk-3) pathway inhibitor; tubulin polymerization inhibitor Colchicine binding site.XRP44X is used as an anti-cancer drug targeting epidermal growth factor receptor.
Definition
ChEBI: [4-(3-chlorophenyl)-1-piperazinyl]-(5-methyl-2-phenyl-3-pyrazolyl)methanone is a member of piperazines.
General Description
A cell-permeable pyrazole compound that is shown to prevent in vitro tubulin polymerization (IC50 = 0.2 μM) by targeting Colchicine (Cat. No. 234115) binding site (Kd = 0.3 μM) in cell-free assays and induce blebs formation in HUVEC cultures by perturbing both tubulin microtubles and actin cytoskeleton structures. Unrelated to its effects on actin and tubulin filaments, XRP44X is also reported to block the activations of Ras and its downstream effector molecules, such as Raf, MEK, Erk, Rsk, and Net (Elk-3/SAP-2/Erp), upon FGF-2 (Cat. No. 341595) stimulation. Potently inhibits the growth of HUVEC, NIH3T3, as well as 9 other cancer cell lines in antiproliferation assays (IC50 ≤11.3 nM).
Biochem/physiol Actions
XRP44X is a Ras-Net (Elk-3) pathway inhibitor; tubulin polymerization inhibitor Colchicine binding site.
in vivo
XRP44X may have therapeutic potential for refractory asthma[1].
XRP44X, an inhibitor of Ras/Erk activation of the transcription factor Elk3, inhibits tumor growth and metastasis in mice. XRP44X inhibits tumor growth and metastasis in nude mice. XRP44X decreases the growth of tumours and the formation of metastases in nude mice[2].
| Animal Model: | Male nude mice (BALB/c nu/nu)[2] |
| Dosage: | 1 mg/kg |
| Administration: | Intraperitoneal injection; treated daily for 6 days |
| Result: | Inhibited cell tumor formation by xenografts in nude mice. |
IC 50
Ras: 10 nM (IC50)
XRP44X Preparation Products And Raw materials
XRP44X Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| VDM Biochemicals | 0330-2528181 | sales@vdmbio.com | United States | 510 | 64 |
| SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD | 13816107857 | sales@fortunechem-sh.com | China | 981 | 58 |
| Shanghai Raise Chemical Technology Co.,Ltd | 15026594951 | rs@raise-chem.com | China | 4904 | 55 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8435 | 60 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Shanghai Yunpun industrial Co.,Ltd | 21-61726900 15202122459; | sales@yunpun.com | China | 497 | 58 |
| Shanghai Pingguo Pharmaceutical Co., Ltd. | 021-20432229 | 2412110556@qq.com | China | 6016 | 55 |
| MQ (shanghai) Pharmaceuticals Co., Ltd. | 13761635123 | sales@linyuepharm.com | China | 5731 | 55 |
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