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NVP-LCQ195

NVP-LCQ195 Structure
NVP-LCQ195 structure
CAS No.
902156-99-4
Chemical Name:
NVP-LCQ195
Synonyms
LCQ-195;LCQ 195;AT-9311;AT 9311;NVP-LCQ195;NVP-LCQ195 (AT9311;NVP-LCQ195, 10 mM in DMSO;NVP-LCQ195 (AT9311; LCQ195);NVP-LCQ195;LCQ-195;AT-9311;NVP LCQ195;LCQ-195;AT-9311;NVP LCQ195;LCQ 195;AT9311;AT 9311
CBNumber:
CB12628205
Molecular Formula:
C17H19Cl2N5O4S
Molecular Weight:
460.33486
MDL Number:
MFCD12031595
MOL File:
902156-99-4.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-06-03 11:24:09
Product description Number Pack Size Price
NVP-LCQ195 ≥98% 42728 5mg $85
NVP-LCQ195 ≥98% 42728 10mg $161
NVP-LCQ195 ≥98% 42728 25mg $382
NVP-LCQ195 ≥98% 42728 50mg $593
NVP-LCQ195 CLB15699 5mg $250
More product size
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NVP-LCQ195 Properties

Density 1.57±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility insoluble in H2O; ≥152.4 mg/mL in DMSO; ≥3.28 mg/mL in EtOH with gentle warming and ultrasonic
form solid
pka 11.10±0.70(Predicted)
color White to off-white

NVP-LCQ195 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 42728 NVP-LCQ195 ≥98% 902156-99-4 5mg $85 2026-04-30 Buy
Cayman Chemical 42728 NVP-LCQ195 ≥98% 902156-99-4 10mg $161 2026-04-30 Buy
Cayman Chemical 42728 NVP-LCQ195 ≥98% 902156-99-4 25mg $382 2026-04-30 Buy
Cayman Chemical 42728 NVP-LCQ195 ≥98% 902156-99-4 50mg $593 2026-04-30 Buy
Biosynth CLB15699 NVP-LCQ195 902156-99-4 5mg $250 2026-06-04 Buy
Product number Packaging Price Buy
42728 5mg $85 Buy
42728 10mg $161 Buy
42728 25mg $382 Buy
42728 50mg $593 Buy
CLB15699 5mg $250 Buy

NVP-LCQ195 Chemical Properties,Uses,Production

Uses

NVP-LCQ195 (AT9311; LCQ195) is a small molecule heterocyclic inhibitor of CDK1, CDK2, CDK3 and CDK5 with IC50 of 1-42 nM. IC50 Value: 1 nM(CDK5/p25 and CDK5/p35); 2 nM(CDK1/cyclinB and CDK2/cyclinA); 5 nM(CDK2/cyclinE); 42 nM(CDK3/cyclinE) Target: CDKs LCQ195 induced cell cycle arrest and eventual apoptotic cell death of MM cells, even at sub-lmol/l concentrations, spared non-malignant cells, and overcame the protection conferred to MM cells by stroma or cytokines of the bone marrow milieu. In MM cells, LCQ195 triggered decreased amplitude of transcriptional signatures associated with oncogenesis, drug resistance and stem cell renewal, including signatures of activation of key transcription factors for MM cells e.g. myc, HIF-1a, IRF4. Bortezomib-treated MM patients whose tumours had high baseline expression of genes suppressed by LCQ195 had significantly shorter progression-free and overall survival than those with low levels of these transcripts in their MM cells. These observations provide insight into the biological relevance of multi-targeted CDK inhibition in MM.

IC 50

Cdk5/p25: 1 nM (IC50); CDK5/p35: 1 nM (IC50); Cdk1/cyclin B: 2 nM (IC50); cdk2/cyclin A: 2 nM (IC50); CDK2/cyclinE: 5 nM (IC50); CDK9/cyclinT1: 15 nM (IC50); CDK3/Cyclin E: 42 nM (IC50); cdk6/cyclin D3: 187 nM (IC50); CDK7/Cyclin H/MAT1: 3564 nM (IC50)

References

[1] McMillin DW, Delmore J, Negri J et al. Molecular and cellular effects of multi-targeted cyclin-dependent kinase inhibition in myeloma: biological and clinical implications. Br J Haematol. 2011 Feb;152(4):420-32. DOI:10.1111/j.1365-2141.2010.08427.x

NVP-LCQ195 Preparation Products And Raw materials

Raw materials

Preparation Products

NVP-LCQ195 Suppliers

Global( 81)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc. 		+1-781-999-5354; support@targetmol.com United States 39040 58
Aladdin Scientific 		tp@aladdinsci.com United States 57505 58
Nanjing Chemlin Chemical Co., Ltd 025-83697070 13770331960 info@chemlin.com.cn China 16101 64
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 9920 65
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7552 61
Shanghai Aladdin Bio-Chem Technology Co.,LTD 400-6206333 13167063860 anhua.mao@aladdin-e.com China 29974 65
MedChemexpress LLC 021-58955995 sales@medchemexpress.cn United States 4861 58
Bide Pharmatech Ltd. 400-400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
InvivoChem 		58
TargetMol Chemicals Inc. 		58
Aladdin Scientific 		58
Nanjing Chemlin Chemical Co., Ltd 64
BOC Sciences 65
Haoyuan Chemexpress Co., Ltd. 61
Shanghai Aladdin Bio-Chem Technology Co.,LTD 65
MedChemexpress LLC 58
Bide Pharmatech Ltd. 60

View Lastest Price from NVP-LCQ195 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
NVP-LCQ195 pictures 2026-06-02 NVP-LCQ195
902156-99-4
 $40.00-148.00 99.56% 10g TargetMol Chemicals Inc.
  • NVP-LCQ195 pictures
  • NVP-LCQ195
    902156-99-4
  • $40.00-148.00
  • 99.56%
  • TargetMol Chemicals Inc.

NVP-LCQ195 Spectrum

NVP-LCQ195(902156-99-4)1HNMR

902156-99-4(NVP-LCQ195)Related Search:

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4-(2,6-Dichlorobenzamido)-N-(1-(methylsulfonyl)piperidin-4-yl)-1H-pyrazole-3-carboxamide NVP-LCQ195;LCQ-195;AT-9311;NVP LCQ195 NVP-LCQ195 AT 9311 AT-9311 LCQ 195 LCQ-195 4-(2,6-Dichlorobenzoylamino)-1H-pyrazole-3-carboxylic acid N-[1-(methylsulfonyl)piperidin-4-yl]amide NVP-LCQ195 (AT9311 NVP-LCQ195 (AT9311; LCQ195) LCQ-195;AT-9311;NVP LCQ195;LCQ 195;AT9311;AT 9311 4-(2,6-dichloro-benzoylamino)-1H-pyrazole-3-carboxylic acid (1-methanesulphonyl-piperidin-4-yl)-amide 1H-Pyrazole-3-carboxamide, 4-[(2,6-dichlorobenzoyl)amino]-N-[1-(methylsulfonyl)-4-piperidinyl]- NVP-LCQ195,AT-9311,NVPLCQ195,NVP-LCQ-195,inhibit,Cyclin dependent kinase,Inhibitor,AT 9311,NVP LCQ195,LCQ195,CDK,LCQ 195 NVP-LCQ195, 10 mM in DMSO 4-[(2,6-dichlorobenzoyl)amino]-N-(1-methylsulfonylpiperidin-4-yl)-1H-pyrazole-5-carboxamide 902156-99-4 C17H19Cl2N5O4S