NVP-BGT226
- CAS No.
- 1245537-68-1
- Chemical Name:
- NVP-BGT226
- Synonyms
- BGT226;CS-382;NVP-BGT226;BGT-226 maleate;NVP-BGT226 (BGT226);BGT226 (NVP-BGT226);NVP-BGT226 (maleate);NVP-BGT226 USP/EP/BP;NVP-BGT226 (free base);BGT-226 (Maleic Acid Salt)
- CBNumber:
- CB52589704
- Molecular Formula:
- C28H25F3N6O2.C4H4O4
- Molecular Weight:
- 650.6044696
- MDL Number:
- MFCD22124895
- MOL File:
- 1245537-68-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | >215°C (dec.) |
|---|---|
| storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| solubility | DMSO (Slightly) |
| form | Solid |
| color | White to Pale Yellow |
| FDA UNII | 4YG62LG876 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| NFPA 704 |
|
NVP-BGT226 price More Price(54)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 22142 | NVP-BGT226 ≥98% | 1245537-68-1 | 1mg | $44 | 2026-04-30 | Buy |
| Cayman Chemical | 22142 | NVP-BGT226 ≥98% | 1245537-68-1 | 5mg | $161 | 2026-04-30 | Buy |
| Cayman Chemical | 22142 | NVP-BGT226 ≥98% | 1245537-68-1 | 10mg | $302 | 2026-04-30 | Buy |
| Cayman Chemical | 22142 | NVP-BGT226 ≥98% | 1245537-68-1 | 25mg | $696 | 2026-04-30 | Buy |
| TRC | TRC-B367500-5MG | BGT 226 | 1245537-68-1 | 5mg | $319 | 2026-06-03 | Buy |
NVP-BGT226 Chemical Properties, Uses, Production
Uses
BGT 226 is a novel phosphatidyl inositol-3 kinase/mammalian target of rapamycin (PI3K/mTOR ) dual inhibitor which has shown to be effective with gefitinib in epidermal growth factor receptor (EGFR) inhibitor-sensitive non-small cell lung cancer (NSCLC) therapy.
Definition
ChEBI: BGT226 is the maleate salt of 8-(6-methoxypyridin-3-yl)-3-methyl-1-[4-(piperazin-1-yl)-3-(trifluoromethyl)phenyl]-1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-one. A dual PI3K/mTOR inhibitor. It has a role as an antineoplastic agent, a mTOR inhibitor and an EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor. It contains a BGT226(1+).
in vivo
BGT226 (2.5 and 5 mg/kg; oral administration for 21 days in male athymic mice) causes 34.7% and 76.1% reduction of the tumor growth on day 21 compared with control[2].
| Animal Model: | Male athymic mice (strain BALB/cAnN.Cg-Foxn1nu/CrlNarl) with FaDu cell xenografted mouse model[2] |
| Dosage: | 2.5 and 5 mg/kg |
| Administration: | Oral administration; 21 days |
| Result: | Caused 34.7% and 76.1% reduction of the tumor growth. |
target
PI3Kα
IC 50
PI3Kα: 4 nM (IC50); PI3Kγ: 38 nM (IC50); PI3Kβ: 63 nM (IC50); mTOR; Autophagy
NVP-BGT226 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| Jinan Trio PharmaTech Co., Ltd. | 0531-88811783 | sales@trio-pharmatech.com | China | 1856 | 62 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4765 | 58 |
| NCE Biomedical Co.,Ltd. | 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 | China | 1490 | 55 | |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7545 | 61 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29977 | 65 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4853 | 58 |
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2774 | 58 |
| Shanghai Huikai Chemical Technology Co., Ltd. | 021-61995394 18916691159 | chemicalsea@163.com | China | 1970 | 58 |
View Latest Price from NVP-BGT226 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
![1-(3-(Trifluoromethyl)-4-(piperazin-1-yl)phenyl)-8-(6-methoxypyridin-3-yl)-3-methyl-1H-imidazo[4,5-c]quinolin-2(3H)-one maleic acid salt pictures](https://img.chemicalbook.com/ProductImageEN/2019-7/Small/04057cb6-484c-4869-977c-5282c25caed9.jpg) |
2019-07-06 | 1-(3-(Trifluoromethyl)-4-(piperazin-1-yl)phenyl)-8-(6-methoxypyridin-3-yl)-3-methyl-1H-imidazo[4,5-c]quinolin-2(3H)-one maleic acid salt
1245537-68-1
|
$7.00 | 1KG | 99% | 200KG | Career Henan Chemical Co |
-
- 1-(3-(Trifluoromethyl)-4-(piperazin-1-yl)phenyl)-8-(6-methoxypyridin-3-yl)-3-methyl-1H-imidazo[4,5-c]quinolin-2(3H)-one maleic acid salt
1245537-68-1
- $7.00
- 99%
- Career Henan Chemical Co
