Rimantadine hydrochloride
- CAS No.
- 1501-84-4
- Chemical Name:
- Rimantadine hydrochloride
- Synonyms
- RIMANTADINE HCL;1-(1-ADAMANTYL)ETHYLAMINE HYDROCHLORIDE;FLUMADINE;remantadin;1-(1-AdaMantyl)ethylaMine hydrochloride 99%;jp61;exp126;ROFLUAL;meradan;MERADANE
- CBNumber:
- CB1270657
- Molecular Formula:
- C12H21N.ClH
- Molecular Weight:
- 215.76
- MDL Number:
- MFCD00072023
- MOL File:
- 1501-84-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | >300 °C(lit.) |
|---|---|
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Chloroform (Slightly), DMSO (Slightly, Heated), Methanol (Slightly), Water(Slightly) |
| form | Solid |
| color | White to Off-White |
| Water Solubility | Freely soluble in water. |
| Merck | 14,8224 |
| InChI | InChI=1S/C12H21N.ClH/c1-8(13)12-5-9-2-10(6-12)4-11(3-9)7-12;/h8-11H,2-7,13H2,1H3;1H |
| InChIKey | OZBDFBJXRJWNAV-UHFFFAOYSA-N |
| SMILES | C1C2CC3(C(N)C)CC1CC(C3)C2.Cl |
| CAS DataBase Reference | 1501-84-4 |
| FDA UNII | JEI07OOS8Y |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P301+P312+P330-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | AU4717000 | |||||||||
| HS Code | 29213000 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| Toxicity | LD50 oral in rat: 640mg/kg | |||||||||
| NFPA 704 |
|
Rimantadine hydrochloride price More Price(76)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHR3267 | Rimantadine Hydrochloride pharmaceutical secondary standard, certified reference material | 1501-84-4 | 500mg | $193 | 2026-04-30 | Buy |
| Sigma-Aldrich | 390593 | 1-(1-Adamantyl)ethylamine hydrochloride 99% | 1501-84-4 | 1g | $66.7 | 2026-04-30 | Buy |
| Sigma-Aldrich | 1604508 | Rimantadine hydrochloride United States Pharmacopeia (USP) Reference Standard | 1501-84-4 | 300mg | $455 | 2026-04-30 | Buy |
| TCI Chemical | R0070 | 1-(1-Adamantyl)ethylamine Hydrochloride >98.0%(N) | 1501-84-4 | 5g | $61 | 2026-04-30 | Buy |
| Cayman Chemical | 23838 | Rimantadine (hydrochloride) ≥98% | 1501-84-4 | 25mg | $36 | 2026-04-30 | Buy |
Rimantadine hydrochloride Chemical Properties, Uses, Production
Description
Rimantadine hydrochloride is an antiviral analogue of amantadine, reportedly useful in the prophylaxis and treatment of influenza A. Compared with amantadine, nmantadine appears to have a lower side-effect profile.
Chemical Properties
White Crystalline Solid
Originator
DuPont (USA)
Uses
Rimantadine Hydrochloride is used as an antiviral agent.
Definition
ChEBI: Rimantadine hydrochloride is an organic molecular entity.
brand name
Flumadine (Forest);Roflual.
Synthesis
78679-71-7
1501-84-4
Example 3: To a Parr hydrogenation flask was added 13.7 g of 1-adamantyl methyl ketoxime (CAS: 78679-71-7), 4.0 g of 5% Pt/C catalyst and 200 ml of glacial acetic acid. After displacing the air in the flask with hydrogen, the hydrogenation reaction was carried out at 30-35 psia (200-240 KPa) hydrogen pressure for 2.25 h at room temperature. After the hydrogen absorption ceased, the reaction mixture was left to stand overnight. Subsequently, the catalyst was filtered off and the acetic acid solution was concentrated to about one-third of the original volume by distillation under reduced pressure. To the concentrated solution, 150 ml of water was added and the pH was adjusted to alkaline with sodium hydroxide solution to obtain an emulsion mixture. The emulsion was extracted twice with 100 ml of dichloromethane. The organic phases were combined, dried with magnesium sulfate and filtered. Hydrogen chloride gas was passed into the clarified dichloromethane solution and a white solid was precipitated. Next, 100 ml of ethyl acetate was added to induce the precipitation of more solids. The solid was collected by filtration to give 11.4 g of amantadine hydrochloride in 75% yield.
References
[1] koff w c, elm jr j l, halstead s b. suppression of dengue virus replication in vitro by rimantadine hydrochloride[j]. the american journal of tropical medicine and hygiene, 1981, 30(1): 184-189.
[2] koff w c, peavy d l, knight v. inhibition of in vitro proliferative responses of human lymphocytes by rimantadine hydrochloride[j]. infection and immunity, 1979, 23(3): 665-669.
[3] hayden f g, monto a s. oral rimantadine hydrochloride therapy of influenza a virus h3n2 subtype infection in adults[j]. antimicrobial agents and chemotherapy, 1986, 29(2): 339-341.
Rimantadine hydrochloride Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sichuan Zhongbang Pharma CO.，LTD | 0830-0830-2585019 13679670161 | sales2@zhongbangst.com | China | 105 | 69 |
| Hangzhou Bingochem Co., Ltd. | 0571-87658025 | sales@bingochem.com | China | 21532 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
View Latest Price from Rimantadine hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-16 | Rimantadine hydrochloride
1501-84-4
|
1KG | 99%-101% | 500KGS | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-09-14 | Rimantadine hydrochloride
1501-84-4
|
2kg | 99% | 20tons | Sinoway Industrial co., ltd. | ||
 |
2026-08-20 | Rimantadine hydrochloride
1501-84-4
|
$1.10 | 1g | 99.0% Min | 100 Tons Min | Dideu Industries Group Limited |
-
- Rimantadine hydrochloride
1501-84-4
- $0.00
- 99%-101%
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Rimantadine hydrochloride
1501-84-4
- 99%
- Sinoway Industrial co., ltd.
-
- Rimantadine hydrochloride
1501-84-4
- $1.10
- 99.0% Min
- Dideu Industries Group Limited
