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Ethambutol dihydrochloride

Ethambutol dihydrochloride structure

CAS No.: 1070-11-7

Chemical Name:: Ethambutol dihydrochloride

Synonyms: ETHAMBUTOL HYDROCHLORIDE;ETHAMBUTOL HCL;Ethambutol HCI;ETHAMBUTOL HCL USP;Etibi;Sural;Ebutol;Etapiam;cl40881;Esanbutol

CBNumber:: CB1256512

Molecular Formula:: C10H24N2O2.2ClH

Molecular Weight:: 277.23

MDL Number:: MFCD21364080

MOL File:: 1070-11-7.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-06-03 11:24:09

Product description	Number	Pack Size	Price
Ethambutol for system suitability European Pharmacopoeia (EP) Reference Standard	Y0000803	10 mg	$167
Ethambutol dihydrochloride antimycobacterial	E4630	25g	$205
Ethambutol hydrochloride European Pharmacopoeia (EP) Reference Standard	E1850000	250 mg	$175
Ethambutol hydrochloride United States Pharmacopeia (USP) Reference Standard	1257007	200mg	$435
(S,S)-N,N'-Bis(1-hydroxy-2-butyl)ethylenediamine Dihydrochloride >98.0%(T)	E1011	5g	$35
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Ethambutol dihydrochloride Properties

Melting point	198-200°C
alpha	D25 +7.6° (c = 2 in water)
storage temp.	2-8°C
solubility	H2O: soluble50mg/mL
form	powder
color	white
optical activity	[α]25/D 6.0 to 6.7°, c = 10 in water
Water Solubility	Slightly soluble in water
Merck	14,3720
BCS Class	3
Major Application	pharmaceutical (small molecule)
InChI	InChI=1/C10H24N2O2.2ClH/c1-3-9(7-13)11-5-6-12-10(4-2)8-14;;/h9-14H,3-8H2,1-2H3;2*1H/t9-,10-;;/s3
InChIKey	AUAHHJJRFHRVPV-UPUBCREWNA-N
SMILES	[C@H](CO)(CC)NCCN[C@@H](CO)CC.Cl.Cl \|&1:0,9,r\|
CAS DataBase Reference	1070-11-7(CAS DataBase Reference)
FDA UNII	QE4VW5FO07
UNSPSC Code	51281511
NACRES	NA.85

Pharmacokinetic data

Protein binding	20-30%
Excreted unchanged in urine	50%
Volume of distribution	1.6-3.2
Biological half-life	3-4 / 5-15

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302

Precautionary statements

P264-P270-P301+P312-P501

Hazard Codes

T,Xi

Risk Statements

61-36/37/38

Safety Statements

53-22-36/37/39-45-36/37-26

WGK Germany

RTECS

EL3854000

HazardClass

IRRITANT

HS Code

29419000

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Oral

NFPA 704

	0
2		0

Ethambutol dihydrochloride price More Price(77)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	Y0000803	Ethambutol for system suitability European Pharmacopoeia (EP) Reference Standard	1070-11-7	10 mg	$167	2026-04-30	Buy
Sigma-Aldrich	E4630	Ethambutol dihydrochloride antimycobacterial	1070-11-7	25g	$205	2026-04-30	Buy
Sigma-Aldrich	E1850000	Ethambutol hydrochloride European Pharmacopoeia (EP) Reference Standard	1070-11-7	250 mg	$175	2026-04-30	Buy
Sigma-Aldrich	1257007	Ethambutol hydrochloride United States Pharmacopeia (USP) Reference Standard	1070-11-7	200mg	$435	2026-04-30	Buy
TCI Chemical	E1011	(S,S)-N,N'-Bis(1-hydroxy-2-butyl)ethylenediamine Dihydrochloride >98.0%(T)	1070-11-7	5g	$35	2026-04-30	Buy

Product number	Packaging	Price	Buy
Y0000803	10 mg	$167	Buy
E4630	25g	$205	Buy
E1850000	250 mg	$175	Buy
1257007	200mg	$435	Buy
E1011	5g	$35	Buy

Ethambutol dihydrochloride Chemical Properties,Uses,Production

Chemical Properties

White Powder

Originator

Myambutol,Lederle,US,1967

Uses

Antibacterial (tuberculostatic)

Uses

Antituberculous

Uses

Ethambutol dihydrochloride it acts as a tuberculostatic antibacterial agent. It is used to treat tuberculosis in combination with other antibiotics to reduce the development of drug resistance. It has been used to study multidrug-resistant tuberculosis (MDR-TB) in highest-incidence-rate.

Definition

ChEBI: The dihydrchloride salt of ethambutol. A bacteriostatic antimycobacterial drug, it is effective against Mycobacterium tuberculosis and some other mycobacteria. It is used in combination with other antituberculous drugs in the treatment of pulm nary and extrapulmonary tuberculosis; resistant strains of M. tuberculosis are readily produced if ethambutol dihydrochloride is used alone.

Manufacturing Process

To 27 grams (2.55 mols) of 2-amino-1-butanol was added 100 grams (1.0 mol) of ethylene dichloride. The mixture was heated at reflux and in a few minutes, the exothermic reaction required the removal of exterior heating. After 10 minutes, exterior heating was recommenced for an additional 20 minutes. The hot mixture was then treated with 300 ml of methanol and then cautiously with 84 grams (2.1 mols) of sodium hydroxide in 80 ml of water.
The precipitated sodium chloride was removed by filtration. The excess 2- amino-1-butanol distilled as light yellow oil at 83° to 87°C/13 mm. The viscous residue distilled at 165° to 170°C/0.6 mm as a light yellow oil which tended to solidify in the air condenser; yield, 108 grams.
Recrystallization by dissolving in 80 ml of hot ethanol, adding about 150 ml of petroleum ether (BP 90° to 100°C) and cooling at 5°C overnight, gave 64 grams of white crystals melting at 128° to 132.5°C. This, on recrystallization from 100 ml of 95% ethanol, gave 35 grams of white crystals melting at 134.5° to 136°C and a second crop of 10 grams melting at 132.5° to 134°C which is the meso base. Its dihydrochloride melts at 202° to 203°C.
From the ethanolic filtrates upon addition of 130 ml of about 4 N ethanolic hydrochloric acid and cooling, there was obtained 55 grams of white crystals melting at 176.5° to 178°C and a second crop of 10 grams melting at 171.5° to 174.5°C. This is the dl racemate dihydrochloride.

brand name

Myambutol (Stat Trade).

Therapeutic Function

Antitubercular

General Description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Biochem/physiol Actions

Ethambutol is bacteriostatic against actively growing TB bacilli. Mycolic acids attach to the 5′-hydroxyl groups of D-arabinose residues of arabinogalactan and form mycolyl-arabinogalactan-peptidoglycan complex in the cell wall. Ethambutol disrupts arabinogalactan synthesis by inhibiting arabinosyltransferases, specifically those in Mycobacterium, interfering with the biosynthesis of arabinogalactans found in the cell wall of mycobacteria and leading to increased cell wall permeability.

Clinical Use

Antibacterial agent:
Tuberculosis

Metabolism

Ethambutol is partially metabolised in the liver to the aldehyde and dicarboxylic acid derivatives, which are inactive.
Up to 80% of a dose appears in the urine within 24 hours, 50% as unchanged drug and 8-15% as the inactive metabolites. About 20% of the dose is excreted unchanged in the faeces.

Ethambutol dihydrochloride Preparation Products And Raw materials

Raw materials

Sodium hydroxide Hydrochloric acid 1,2-Dichloroethane 2-AMINO-1-BUTANOL

Preparation Products

Ethambutol dihydrochloride Suppliers

Global( 436)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8738	58
Wuhan Fortuna Chemical Co., Ltd	+86-27-59207850	info@fortunachem.com	China	5983	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-86-13131129325 +8613131129325	sales1@chuanghaibio.com	China	5228	58
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971	deasea125996@gmail.com	China	2472	58
Shaanxi TNJONE Pharmaceutical Co., Ltd	+8618092446649	sarah@tnjone.com	China	1143	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21587	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29815	58
Xiamen AmoyChem Co., Ltd	+86-86-5926051114 +8615060885618	sales@amoychem.com	China	6366	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
SIMAGCHEM CORP	+86-5922680277 +86-13806087780	sale@simagchem.com	China	17346	58

Supplier	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	58
Wuhan Fortuna Chemical Co., Ltd	58
Hebei Chuanghai Biotechnology Co,.LTD	58
Henan Bao Enluo International TradeCo.，LTD	58
Shaanxi TNJONE Pharmaceutical Co., Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
Xiamen AmoyChem Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
SIMAGCHEM CORP	58

View Lastest Price from Ethambutol dihydrochloride manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-06-05	Ethambutol dihydrochloride 1070-11-7		1KG	98%~100.5%,USP40	5tons/month	WUHAN FORTUNA CHEMICAL CO., LTD
2026-06-02	Ethambutol dihydrochloride 1070-11-7	$42.00		98.00%	10g	TargetMol Chemicals Inc.
2026-06-02	Ethambutol dihydrochloride 1070-11-7	$42.00		98.00%	10g	TargetMol Chemicals Inc.

Ethambutol dihydrochloride
1070-11-7
98%~100.5%,USP40
WUHAN FORTUNA CHEMICAL CO., LTD

Ethambutol dihydrochloride
1070-11-7
$42.00
98.00%
TargetMol Chemicals Inc.

Ethambutol dihydrochloride
1070-11-7
$42.00
98.00%
TargetMol Chemicals Inc.

Ethambutol dihydrochloride Spectrum

Ethambutol dihydrochloride(1070-11-7)MS Ethambutol dihydrochloride(1070-11-7)¹HNMR

1070-11-7(Ethambutol dihydrochloride )Related Search:

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1-beta-D-Arabinofuranosylcytosine hydrochloride Mexiletine hydrochloride tert-Butanol Dihydrochloride Eperisone hydrochloride

Itopride hydrochloride Etilefrine hydrochloride Ethambutol Related Compound A (15 mg) ((2R,2'S)-2,2'-[ethane-1,2-diylbis(azanediyl)]dibutan-1-ol)

1of4

Emb, 2,2μ-(1,2-Ethanediyldiimino)bis-1-butanol dihydrochloride (R)-2,2'-(1,2-Ethanediyldiimino)bis-1-butanol dihydrochloride (S,S)-N,N'-Bis(1-hydroxy-2-butyl)ethylenediaMine Dihydrochloride (2S,2'S)-2,2'-(Ethane-1,2-diylbis(azanediyl))bis(butan-1-ol) dihydrochloride Ethambutol Hydrochlorid 1-Butanol, 2,2'-(1,2-ethanediyldiimino)bis-, hydrochloride (1), (2S,2'S)- Esanbutol Ethambutol dihydrochloride,2,2′-(1,2-Ethanediyldiimino)bis-1-butanol dihydrochloride, Emb Ethambutol Hydrochloride (200 mg) 2,2'-[1,2-Ethanediyldi(imino)]di(1-butanol) dihydrochloride (S,S)-2,2'-(1,2-EthanediyldiiMino)-bis-1-butanol Dihydrochloride 2,2'-(Ethane-1,2-diylbis(azanediyl))bis(butan-1-ol) dihydrochloride 1-Butanol, 2,2'-(ethylenediimino)di-, dihydrochloride, (+)- (8CI) d-2,2'-(Ethylenediimino)-di-1-butanol dihydrochloride Ebutol Etapiam Ethambutold dihydrochloride Etibi Myambutol Mycobutol Sural 2,2’-(1,2-ethanediyldiimino)bis-,dihydrochloride,(r-(r*,r*))-1-butano 2,2’-(ethylenediimino)di-,dihydrochloride,(+)-1-butano cl40881 dadibutol ETHAMBUTOL DIHYDROCHLORIDE, ANTIMYCO [s-(r*,r*)]-2,2'-(ethylenediimino)dibutan-1-ol dihydrochloride ETHAMBUTOL DIHYDROCHLORIDE EMB DIHYDROCHLORIDE ETHAMBUTOL 2HCL EthambutolHclEthambutolHclBp Dexambutol (+)-2,2'-(Ethylenediimino)di-1-butanol dihydrochloride 1-Butanol, 2,2'-(1,2-ethanediyldiimino)bis-, dihydrochloride, (2S,2'S)- 1-Butanol, 2,2'-(1,2-ethanediyldiimino)bis-, dihydrochloride, [S-(R*,R*)]- 2,2'-(1,2-ETHANEDIYLDIIMINO)BIS-1-BUTANOL DIHYDROCHLORIDE Ethambutol hydrochloride reference substance Ethambutol for system suitability CRS Ethambutol hydrochloride CRS (S,S)-N,N'-Bis(1-hydroxy-2-butyl)ethylenediamineDihydrochloride> Ethambutol dihydrochloride USP/EP/BP Ethambutol for system suitability (Y0000803) Ethambutol HydrochlorideQ: What is Ethambutol Hydrochloride Q: What is the CAS Number of Ethambutol Hydrochloride Q: What is the storage condition of Ethambutol Hydrochloride Q: What are the applications of Ethambutol Hydrochloride TIANFU CHEM Ethambutol dihydrochloride Ethambutol dihydrochloride-HBW Ethambutol Dihydrochloride (ETB.2HCl), 98% Ethambutol Hydrochloride (1257007) S-(R*,R*)]-2,2'-(Ethylendiimino)dibutan-1-oldihydrochlorid 2H4]-Ethambutol dihydrochloride salt (+)-S,S-Ethambutol dihydrochloride salt Ethambutol Hydrochlorido Myambutol dihydrochloride (S,S)-N,N'-Bis(1-hydroxy-2-butyl)ethylenediamine Dihydrochloride, ≥ 98.0% DIHYDROGEN ETHAMBUTOL DICHLORIDE Ethambutol dihydrochloride bp2009 99% Ethambutol hydrochloride RS Ethambutol dihydrochloride (Standard) ETHAMBUTOL HCL USP