PD-L1 inhibitor 1
- CAS No.
- 1675203-84-5
- Chemical Name:
- PD-L1 inhibitor 1
- Synonyms
- BMS-202;CS-2416;PD1 inhibitor 2;PD-1 inhibitor 2;PD 1 inhibitor 2;PD-L1 inhibitor 2;PD-L1 inhibitor 1;PD1-PDL1 inhibitor 2;BMS-202, 10 mM in DMSO;PD-1/PD-L1 inhibitor 2(BMS-202)
- CBNumber:
- CB13043328
- Molecular Formula:
- C25H29N3O3
- Molecular Weight:
- 419.52
- MDL Number:
- MFCD29905455
- MOL File:
- 1675203-84-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 611.4±55.0 °C(Predicted) |
|---|---|
| Density | 1.133±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Soluble in DMSO (up to at least 25 mg/ml) or in Ethanol (up to at least 25 mg/ml) |
| form | solid |
| pka | 16.06±0.46(Predicted) |
| color | White |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| FDA UNII | KDA2HUE7KP |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| NFPA 704 |
|
PD-L1 inhibitor 1 price More Price(49)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 19132 | PD-1/PD-L1 Inhibitor 2 ≥98% | 1675203-84-5 | 1mg | $49 | 2026-04-30 | Buy |
| Cayman Chemical | 19132 | PD-1/PD-L1 Inhibitor 2 ≥98% | 1675203-84-5 | 5mg | $190 | 2026-04-30 | Buy |
| Cayman Chemical | 19132 | PD-1/PD-L1 Inhibitor 2 ≥98% | 1675203-84-5 | 10mg | $354 | 2026-04-30 | Buy |
| Cayman Chemical | 19132 | PD-1/PD-L1 Inhibitor 2 ≥98% | 1675203-84-5 | 25mg | $634 | 2026-04-30 | Buy |
| ChemScene | CS-5441 | BMS-202 99.48% | 1675203-84-5 | 5mg | $143 | 2026-06-04 | Buy |
PD-L1 inhibitor 1 Chemical Properties, Uses, Production
Description
The programmed death-1/programmed death-ligand 1 (PD-1/PD-L1) interaction plays a dominant role in the suppression of T cell responses, especially in a tumor microenvironment, protecting tumor cells from lysis. PD-1/PD-L1 inhibitor 2 is reported to prevent the interaction of PD-L1 with PD-1 with an IC50 value of 18 nM.
Uses
BMS-202 is a Novel inhibitor of the PD-1/PD-L1 interaction by inducing PD-L1 dimerization through PD-1 interacting surface.
in vivo
BMS-202 (20 mg/kg; intraperitoneal injection; daily; for 9 days; NOG-dKO mice) treatment shows a clear antitumor effect compared with the controls, in humanized MHC- dKO NOG mice[2].
| Animal Model: | NOG-dKO mice (8-week-old) injected with SCC-3 cells[2] |
| Dosage: | 20 mg/kg |
| Administration: | Intraperitoneal injection; daily; for 9 days |
| Result: | Showed 41% growth inhibitory activity against humanized mouse-transplanted human lymphoma SCC-3 cells. |
References
[1] KRZYSZTOF M ZAK. Structural basis for small molecule targeting of the programmed death ligand 1 (PD-L1).[J]. Oncotarget, 2016: 30323-30335. DOI:10.18632/oncotarget.8730
[2] KATARZYNA GUZIK. Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Death-Ligand 1 (PD-1/PD-L1) Interaction via Transiently Induced Protein States and Dimerization of PD-L1[J]. Journal of Medicinal Chemistry, 2017, 60 13: 5857-5867. DOI:10.1021/acs.jmedchem.7b00293
PD-L1 inhibitor 1 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2915 | 55 | |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9407 | 55 |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4765 | 58 |
| ShangHai YuanYe Biotechnology Co., Ltd. | 15026964105 | shyysw007@163.com | China | 4998 | 60 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4853 | 58 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 18149758185 | sales-cpd@caerulumpharma.com | China | 3493 | 58 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Shanghai Macklin Biochemical Co.,Ltd. | 15221275939 15221275939 | shenlinxing@macklin.cn | China | 15775 | 55 |
| Hangzhou J&H Chemical Co., Ltd. | 0571-87396432 | sales@jhechem.com | China | 14905 | 59 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4860 | 55 |
View Latest Price from PD-L1 inhibitor 1 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-14 | BMS-202
1675203-84-5
|
$102.00-323.00 | 98.29% | 10g | TargetMol Chemicals Inc. | ||
 |
2020-01-10 | PD-L1 inhibitor 1
1675203-84-5
|
$5.50 | 1KG | 98%min | 1kg,10kg,100kg | Career Henan Chemical Co |
-
- BMS-202
1675203-84-5
- $102.00-323.00
- 98.29%
- TargetMol Chemicals Inc.
-
- PD-L1 inhibitor 1
1675203-84-5
- $5.50
- 98%min
- Career Henan Chemical Co
