BMS813160
- CAS No.
- 1286279-29-5
- Chemical Name:
- BMS813160
- Synonyms
- CS-2742;BMS813160;BMS-585059;BMS-813160, 10 mM in DMSO;BMS-813160;BMS813160;BMS 813160;N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2-oxopyrrolidin-1-yl)cyclohexyl)acetamide;Inhibitor,CC chemokine receptor,CCR,dual antagonist,peritonitis,CD11b,BMS-813160,inflammation,CTX,thioglycollate,BMS813160,inhibit,mouse,oral;Acetamide, N-[(1R,2S,5R)-5-[(1,1-dimethylethyl)amino]-2-[(3S)-3-[[7-(1,1-dimethylethyl)pyrazolo[1,5-a]-1,3,5-triazin-4-yl]amino]-2-oxo-1-pyrrolidinyl]cyclohexyl]-
- CBNumber:
- CB23364411
- Molecular Formula:
- C25H40N8O2
- Molecular Weight:
- 484.64
- MDL Number:
- MFCD31540731
- MOL File:
- 1286279-29-5.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| BMS 813160 | 28421 | 1mg | $242 |
| BMS 813160 | 28421 | 5mg | $965 |
| BMS-813160 | B595925 | 1mg | $305 |
| BMS-813160 99.89% | CS-0033469 | 10mg | $450 |
| BMS-813160 99.89% | CS-0033469 | 5mg | $280 |
| More product size | |||
| Density | 1.31±0.1 g/cm3(Predicted) |
|---|---|
| storage temp. | 4°C, protect from light |
| solubility |
DMSO:61.0(Max Conc. mg/mL);125.86(Max Conc. mM) Ethanol:97.0(Max Conc. mg/mL);200.14(Max Conc. mM) |
| pka | 15.46±0.60(Predicted) |
| form | A crystalline solid |
| color | White to off-white |
| InChIKey | CMVHFGNTABZQJU-HCXYKTFWSA-N |
| SMILES | C(N[C@@H]1C[C@H](NC(C)(C)C)CC[C@@H]1N1CC[C@H](NC2N3N=C(C(C)(C)C)C=C3N=CN=2)C1=O)(=O)C |
| FDA UNII | 83U7957287 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS05,GHS08,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H315-H318-H334-H317-H341-H361-H370-H335-H413 | |||||||||
| Precautionary statements | P201-P202-P260-P264-P270-P272-P273-P280-P284-P302+P352-P304+P341-P305+P351+P338-P310-P308+P313-P321-P362+P364-P333+P313-P342+P311-P363-P405-P501 | |||||||||
| NFPA 704 |
|
BMS813160 price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 28421 | BMS 813160 | 1286279-29-5 | 1mg | $242 | 2024-03-01 | Buy |
| Cayman Chemical | 28421 | BMS 813160 | 1286279-29-5 | 5mg | $965 | 2024-03-01 | Buy |
| TRC | B595925 | BMS-813160 | 1286279-29-5 | 1mg | $305 | 2021-12-16 | Buy |
| ChemScene | CS-0033469 | BMS-813160 99.89% | 1286279-29-5 | 10mg | $450 | 2021-12-16 | Buy |
| ChemScene | CS-0033469 | BMS-813160 99.89% | 1286279-29-5 | 5mg | $280 | 2021-12-16 | Buy |
BMS813160 Chemical Properties,Uses,Production
Description
BMS 813160 is a dual antagonist of chemokine receptor 2 (CCR2) and CCR5 (IC50s = 6.2 and 3.6 nM, respectively, in radioligand binding assays). It inhibits chemotaxis induced by the CCR2 ligand MCP-1 in THP-1 cells the CCR5 ligand MIP-1β in isolated peripheral T cells with IC50 values of 0.8 and 1.1 nM, respectively. BMS 813160 inhibits peritoneal monocyte and macrophage infiltration in an hCCR-2 KI mouse model of thioglycolate-induced peritonitis, with 54% inhibition when administered at a dose of 50 mg/kg twice per day.
Uses
BMS-813160, a dual CCR2/CCR5 chemokine antagonist.
in vivo
BMS-813160 (10-160 mg/kg; p.o. twice a day for two days) inhibits the migration of inflammatory monocytes and macrophages in mouse thioglycollate-induced peritonitis model, and shows excellent oral bioavailability[2].
| Animal Model: | Human-CCR2 knock-in C57BL/6 male mice with thioglycollate injection[2] |
| Dosage: | 10, 50 and 160 mg/kg |
| Administration: | Oral gavage; 10-160 mg/kg twice a day; for two days |
| Result: | Dose-dependently reduced inflammatory monocyte and macrophage infiltration in the peritoneum. |
IC 50
CCR5: 3.6 nM (IC50); CCR2: 6.2 nM (IC50)
References
[1] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
[2] NORMAN P. A dual CCR2/CCR5 chemokine antagonist, BMS-813160 Evaluation of WO2011046916.[J]. Expert Opinion on Therapeutic Patents, 2011, 21 12: 1919-1924. DOI: 10.1517/13543776.2011.622750
BMS813160 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32469 | 58 |
| Shenzhen Shengda Pharma Limited | 755-85269922 +8613424394241 | sales@shengdapharm.com | CHINA | 310 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39042 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 5221 | 58 |
| Wuhan Jingkangen Biomedical Technology Co., Ltd | 13720134139 086-15871494362 13720134139 | orders@jknbiochem.com | China | 7052 | 58 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 12952 | 65 |
View Lastest Price from BMS813160 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-03-13 | BMS-813160
1286279-29-5
|
US $57.00-197.00 / mg | 99.79% | 10g | TargetMol Chemicals Inc. |
-
- BMS-813160
1286279-29-5
- US $57.00-197.00 / mg
- 99.79%
- TargetMol Chemicals Inc.
