Hexapeptide-11
- CAS No.
- 161258-30-6
- Chemical Name:
- Hexapeptide-11
- Synonyms
- Hexapeptide-11;H-Phe-Val-Ala-Pro-Phe-Pro-OH;L-Proline, L-phenylalanyl-L-valyl-L-alanyl-L-prolyl-L-phenylalanyl-;(2S)-1-[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-phenylpropanoyl]amino]-3-methylbutanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoyl]pyrrolidine-2-carboxylic acid
- CBNumber:
- CB13134442
- Molecular Formula:
- C36H48N6O7
- Molecular Weight:
- 676.8
- MDL Number:
- MOL File:
- 161258-30-6.mol
- MSDS File:
- SDS
| Boiling point | 1035.1±65.0 °C(Predicted) |
|---|---|
| Density | 1.269±0.06 g/cm3(Predicted) |
| form | Solid |
| pka | 3.43±0.20(Predicted) |
| color | White to off-white |
| Sequence | Phe-Val-Ala-Pro-Phe-Pro |
| Cosmetics Ingredients Functions | SKIN CONDITIONING |
| InChIKey | GFEYWOGCSROPRT-OBXVVNIGSA-N |
| SMILES | C(O)(=O)[C@@H]1CCCN1C(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC1=CC=CC=C1)N |
| EWG's Food Scores | 1 |
| FDA UNII | NCJ63WU6BY |
Hexapeptide-11 Chemical Properties,Uses,Production
Skin Benifits
Pentamide-6, or Hexapeptide-11, was originally isolated from Saccharomyces yeast fermentation. Pentamide-6 directly affects dermal cell senescence by downregulating key genes involved in apoptosis. The cellular proteins ataxia telangiectasia mutated (ATM) and p53 have been shown to be hyperactive in degenerative aging pathologies, leading to cellular senescence. Senescent cells in skin can cause dermal thinning, loss of subcutaneous fat, decreased hair growth, and slower wound healing. Pentamide-6 is a hexapeptide with the structure Phe-Val-Ala-Pro-Phe-Pro (FVAPFP). This oligopeptide helps promote younger looking skin by reversibly downregulating ATMP and p53 at peptide concentrations of 0.1%–1.0%. By targeting the cellular aging process, FVAPFP has been shown to modulate senescence in both intrinsically and extrinsically aged fibroblasts, as well as extrinsically aged dermal papillae cells in vitro. This signal oligopeptide has been shown to increase fibrillogenesis through growth factors, and ECPs increase transmembrane and cell shock proteins, and promote hair growth. A clinical trial conducted on 25 subjects showed its ability to increase skin elasticity and reduce deformity in facial skin.
Description
Hexapeptide-11 is a novel modulator of the proteostasis network in human diploid fibroblasts.
Uses
Hexapeptide-11 reduces the appearance of fine lines and wrinkles, making this an excellent addition to all kinds of skin care and anti-aging products. It has a unique set of amino acids that help to manipulate collagen levels and boost elasticity in the skin.
benefits
Hexapeptide-11 promote the fibroblast to produce collagen and elastin,enhance skin elasticity and firmness, fadeout the fine wrinkle.Its recommended dosage is 0.5~3%.
Physiological effects
Exposure of fibroblasts to Hexapeptide-11 promoted dose and time-dependent activation of proteasome, autophagy, chaperones and antioxidant responses related genes. Moreover, it promoted increased nuclear accumulation of Nrf2; higher expression levels of proteasomal protein subunits and increased proteasome peptidase activities. In line with these findings we noted that Hexapeptide-11 conferred significant protection in fibroblasts against oxidative-stress-mediated premature cellular senescence, while at in vivo skin deformation assays in human subjects it improved skin elasticity.
Hexapeptide-11 Preparation Products And Raw materials
Raw materials
Preparation Products
Hexapeptide-11 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| HR Biotechnology Co.,Ltd | +8618565342920 | sales@chembj.net | China | 282 | 58 |
| Anhui Ruihan Technology Co., Ltd | +8617756083858 | daisy@anhuiruihan.com | China | 973 | 58 |
| Shijiazhuang Saixin Technology Co., Ltd. | +86-16632312509 +86-16632315022 | saixinkeji@aliyun.com | China | 86 | 58 |
| zhuzhou dingcheng meihei comestic co.,ltd | +8618873369619 | dingchengbusiness8@163.com | China | 260 | 58 |
| Hangzhou Hyper Chemicals Limited | +86-0086-57187702781 +8613675893055 | info@hyper-chem.com | China | 310 | 58 |
| Shanghai Getian Industrial Co., LTD | +86-15373193816 | mike@ge-tian.com | China | 269 | 58 |
| Strong peptide cross-border e-commerce Co. LTD | +undefined13930052870 | qt01@qiangtaipharm.com | China | 84 | 58 |
| ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | +86-13017695106 +86-13676922317 | jiuyitime@fdachem.com | China | 16513 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10404 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
Related articles
- What does Hexapeptide-11 do for skin and hair?
- Hexapeptide-11 has been shown to be effective in improving skin elasticity, enhancing nuclear accumulation of Nrf2, increasing....
- May 28，2024
- Benefits and applications of Hexapeptide-11
- Hexapeptide-11 is a bio fermented peptide that has been shown in studies, run on human dermal fibroblasts, to upregulate key g....
- Apr 21，2022
View Lastest Price from Hexapeptide-11 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-28 | Hexapeptide-11
161258-30-6
|
US $0.00-0.00 / kg | 1kg | 99% | 500 | HR Biotechnology Co.,Ltd | |
 |
2026-04-24 | Hexapeptide-11
161258-30-6
|
US $0.00-0.00 / Gram | 1Gram | 98% | 50KG | Hangzhou Hyper Chemicals Limited | |
 |
2026-04-17 | Hexapeptide-11
161258-30-6
|
US $2.00-5.00 / kg | 1kg | 99% | 100kg | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD |
-
- Hexapeptide-11
161258-30-6
- US $0.00-0.00 / kg
- 99%
- HR Biotechnology Co.,Ltd
-
- Hexapeptide-11
161258-30-6
- US $0.00-0.00 / Gram
- 98%
- Hangzhou Hyper Chemicals Limited
-
- Hexapeptide-11
161258-30-6
- US $2.00-5.00 / kg
- 99%
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
