KDM5-IN-1
- CAS No.
- 1628210-26-3
- Chemical Name:
- KDM5-IN-1
- Synonyms
- KDM5-IN-1;KDM5-IN-48;KDM5 inhibitor 1;KDM5-IN-1, 10 mM in DMSO;KDM5 inhibitor compound 48;KDM5 IN 1,inhibit,Histone Demethylase,Inhibitor,KDM-5-IN-1,KDM5IN1;5-(1-tert-butyl-1H-pyrazol-4-yl)-7-oxo-6-(propan-2-yl)-4H,7H-pyrazolo[1,5-a]pyrimidine-3-carbonitrile;Pyrazolo[1,5-a]pyrimidine-3-carbonitrile, 5-[1-(1,1-dimethylethyl)-1H-pyrazol-4-yl]-4,7-dihydro-6-(1-methylethyl)-7-oxo-
- CBNumber:
- CB13169587
- Molecular Formula:
- C17H20N6O
- Molecular Weight:
- 324.38
- MDL Number:
- MFCD30747843
- MOL File:
- 1628210-26-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352-P305+P351+P338-P321-P332+P313-P337+P313-P362 |
KDM5-IN-1 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | DQC21026 | KDM5-IN-1 | 1628210-26-3 | 5mg | $900 | 2026-06-04 | Buy |
| Biosynth | DQC21026 | KDM5-IN-1 | 1628210-26-3 | 10mg | $900 | 2026-06-04 | Buy |
| Biosynth | DQC21026 | KDM5-IN-1 | 1628210-26-3 | 25mg | $1233 | 2026-06-04 | Buy |
| Biosynth | DQC21026 | KDM5-IN-1 | 1628210-26-3 | 50mg | $2206.5 | 2026-06-04 | Buy |
| ChemScene | CS-6443 | KDM5-IN-1 99.52% | 1628210-26-3 | 1mg | $76 | 2026-06-04 | Buy |
KDM5-IN-1 Chemical Properties, Uses, Production
Uses
KDM5-IN-1 is a potent, selective and orally bioavailable KDM5 inhibitor with an IC50 of 15.1 nM.
in vivo
When dosed orally in mice at 50 mg/kg twice a day, KDM5-IN-1 shows an unbound maximal plasma concentration Cmax>15-fold over its cell EC50, thereby providing a robust chemical probe for studying KDM5 biological functions in vivo[1].
IC 50
KDM5
References
[1] Liang J, et al. Lead optimization of a pyrazolo[1,5-a]pyrimidin-7(4H)-one scaffold to identify potent, selective and orally bioavailable KDM5 inhibitors suitable for in vivo biological studies. Bioorg Med Chem Lett. 2016 Aug 15;26(16):4036-41. DOI:10.1016/j.bmcl.2016.06.078
KDM5-IN-1 Preparation Products And Raw materials
Raw materials
Preparation Products
KDM5-IN-1 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Wuhan TCASChem Technology Co., Ltd. | 027-86697669 13986148687 | sales@tcaschem.com | China | 3989 | 55 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7717 | 56 |
| Hangzhou Milestone Pharmtech Co., Ltd. | 0571-82896630 18969958410 | sales_hz@milestonepharmtech.com | China | 4906 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 17801761073 18101056239 | 3193328036@qq.com | China | 28150 | 68 |
| Angel Pharmatech, Ltd. | 17317130613 | 3358272972@qq.com | China | 3307 | 58 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9718 | 58 |
