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ChemicalBook >> CAS DataBase List >>2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)-

2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)-

2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- Structure
2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- structure
CAS No.
6318-41-8
Chemical Name:
2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)-
Synonyms
PI 3-Kγ Inhibitor VII;PI 3-Kγ Inhibitor VII;AS-041164, 10 mM in DMSO;AS-041164, PI3K gamma inhibitor;PI 3-Kγ Inhibitor VII - CAS 6318-41-8 - Calbiochem;2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)-;5-(Benzo[d][1,3]dioxol-5-ylmethylene)thiazolidine-2,4-dione;Inhibitor,PI3Kγ,inhibit,Phosphoinositide 3-kinase,AS 041164,AS-041164,anti-inflammatory,neutrophil,recruitment,AS041164,RANTES,PI3K
CBNumber:
CB13232856
Molecular Formula:
C11H7NO4S
Molecular Weight:
249.24
MDL Number:
MFCD18382117
MOL File:
6318-41-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-31 08:06:23
Product description Number Pack Size Price
PI 3-Kγ Inhibitor VII - CAS 6318-41-8 - Calbiochem 528114 5mg $238
AS-041164 ≥98% 13622 5mg $80
AS-041164 ≥98% 13622 10mg $102
AS-041164 ≥98% 13622 25mg $228
AS-041164 ≥98% 13622 50mg $381
Request For Quotation

2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- Properties

Melting point 256-258 °C(Solvent: Ethanol)
Density 1.595±0.06 g/cm3(Predicted)
storage temp. +2C to +8C
solubility Soluble in DMSO (up to 25 mg/ml).
form Yellow solid
pka 7.13±0.20(Predicted)
color Yellow
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChI 1S/C11H7NO4S/c13-10-9(17-11(14)12-10)4-6-1-2-7-8(3-6)16-5-15-7/h1-4H,5H2,(H,12,13,14)/b9-4+
InChIKey SDGWAUUPHUBJNQ-RUDMXATFSA-N
UNSPSC Code 12352200

SAFETY

Risk and Safety Statements

WGK Germany  WGK 1
Storage Class 11 - Combustible Solids

2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- price More Price(26)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 528114 PI 3-Kγ Inhibitor VII - CAS 6318-41-8 - Calbiochem 6318-41-8 5mg $238 2023-01-07 Buy
Cayman Chemical 13622 AS-041164 ≥98% 6318-41-8 5mg $80 2026-04-30 Buy
Cayman Chemical 13622 AS-041164 ≥98% 6318-41-8 10mg $102 2026-04-30 Buy
Cayman Chemical 13622 AS-041164 ≥98% 6318-41-8 25mg $228 2026-04-30 Buy
Cayman Chemical 13622 AS-041164 ≥98% 6318-41-8 50mg $381 2026-04-30 Buy
Product number Packaging Price Buy
528114 5mg $238 Buy
13622 5mg $80 Buy
13622 10mg $102 Buy
13622 25mg $228 Buy
13622 50mg $381 Buy

2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- Chemical Properties,Uses,Production

Description

The phosphatidylinositol 3-kinases (PI3Ks) are lipid and protein kinases involved in diverse biological processes, including cell growth, migration, and metabolism. AS-041164 is a potent inhibitor of PI3K with selectivity for the class IB isoform PI3Kγ (IC50 = 70 nM), compared to PI3Kα (IC50 = 240 nM), PI3Kβ (IC50 = 1.45 μM), and PI3Kδ (IC50 =1.70 μM). When tested at 1.0 μM, it shows little or no activity against 38 other common kinases. When given orally to mice, AS-041164 shows a pharmacokinetic profile that is similar to the general PI3K inhibitor LY294002 but is three times more potent (ED50 = 27.4 mg/kg for AS-041164 versus 81.6 mg/kg for LY294002) in blocking neutrophil recruitment induced by RANTES.

Uses

AS-041164 is a potent, selective and orally active PI3Kγ isoform inhibitor with an IC50 of 70 nM. AS-041164 shows less activity against PI3Kα, PI3Kβ, and PI3Kδ (IC50s of 240 nM, 1.45 μM, and 1.70 μM, respectively). AS-041164 has anti-inflammatory effects[1].

in vivo

AS-041164 (10-100 mg/kg; oral administration; once) treatment results in the reduction of inflammatory swelling in the model of carrageenan-induced paw edema[1].
AS-041164 (3-100 mg/kg p.o.) treatment dose-dependently decreases r-h regulated on activation normal T cell expressed and secreted (RANTES)-induced neutrophil recruitment in mice. The ED50 value for AS-041164 is 27.35 mg/kg. AS-041164 blocks RANTES-induced chemotaxis and reduces the level of AKT phosphorylation[1].

Animal Model:Male Wistar rats (100-150 g) injected with carrageenan[1]
Dosage:10 mg/kg, 30 mg/kg, 100 mg/kg
Administration:Oral administration; once
Result:Induced a significant reduction of paw thickness.

IC 50

PI3Kγ: 70 nM (IC50); PI3Kα: 240 nM (IC50); PI3Kβ: 1.4 μM (IC50); PI3Kδ: 1.7 μM (IC50)

References

[1] CHIARA FERRANDI. Phosphoinositide 3-kinase gamma inhibition plays a crucial role in early steps of inflammation by blocking neutrophil recruitment.[J]. Journal of Pharmacology and Experimental Therapeutics, 2007, 322 3: 923-930. DOI:10.1124/jpet.107.123026

2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- synthesis

2295-31-0
120-57-0
6318-41-8
Synthesis of 2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- from 2,4-Thiazolidinedione and Piperonyl aldehyde

2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- Preparation Products And Raw materials

Raw materials

Preparation Products

2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- Suppliers

Global( 36)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
BOC Sciences 		16314854226; +8616314854226 inquiry@bocsci.com United States 19852 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6378 58
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9799 58
Shanghai YuanYe Biotechnology Co., Ltd. 13636370518 shyysw007@163.com China 89667 60
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720 klq@cw-bio.com China 9782 55
Shanghai Rechem science Co., Ltd. 021-31433387 15618786686 sales@rechemscience.com China 2965 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11123 58
Zhejiang Huida Biotech Co., LTD 0571-89903022 18679456698 zilong@hizyme.com China 8001 58
MedBioPharmaceutical Technology Inc 021-69568360 18916172912 order@med-bio.cn China 8137 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
BOC Sciences 		58
InvivoChem 		58
Shanghai EFE Biological Technology Co., Ltd. 58
Shanghai YuanYe Biotechnology Co., Ltd. 60
Tianjin Kailiqi Biotechnology Co., Ltd. 55
Shanghai Rechem science Co., Ltd. 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Zhejiang Huida Biotech Co., LTD 58
MedBioPharmaceutical Technology Inc 58

View Lastest Price from 2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
AS-041164 pictures 2026-08-08 AS-041164
6318-41-8
 $31.00-92.00 99.59% 10g TargetMol Chemicals Inc.
  • AS-041164 pictures
  • AS-041164
    6318-41-8
  • $31.00-92.00
  • 99.59%
  • TargetMol Chemicals Inc.

2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- Spectrum

2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)-(6318-41-8)1HNMR

6318-41-8(2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)-)Related Search:

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2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- PI 3-Kγ Inhibitor VII - CAS 6318-41-8 - Calbiochem Inhibitor,PI3Kγ,inhibit,Phosphoinositide 3-kinase,AS 041164,AS-041164,anti-inflammatory,neutrophil,recruitment,AS041164,RANTES,PI3K 5-(Benzo[d][1,3]dioxol-5-ylmethylene)thiazolidine-2,4-dione AS-041164, PI3K gamma inhibitor AS-041164, 10 mM in DMSO PI 3-Kγ Inhibitor VII PI 3-Kγ Inhibitor VII 6318-41-8