2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- synthesis
1synthesis methods
- Product Name:2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)-
- CAS Number:6318-41-8
- Molecular formula:C11H7NO4S
- Molecular Weight:249.24
Yield:6318-41-8 99%
Reaction Conditions:
with urea in neat (no solvent); for 2 h;Knoevenagel Condensation;
Steps:
Optimization of the reaction conditions for the synthesis of5-arylidene-thiazolidine-2,4-dione derivatives
General procedure: To a 25 mL flask, 50 mg of the catalyst, 1 mmol of TZDand 1 mmol of aldehyde were added. The reaction mixturewas maintained under constant agitation for 2 h at 80 C.
References:
De Paiva, Raíssa K.C.;Da Silva, Jamerson F.;Moreira, Hudieyllen A.;Pinto, Osvaldo G.;Camargo, Lilian T.F.M.;Naves, Plínio L.F.;Camargo, Ademir J.;Ribeiro, Luciano;Ramos, Luciana M. [Journal of the Brazilian Chemical Society,2019,vol. 30,# 1,p. 164 - 172]