ChemicalBook >> CAS DataBase List >>2-Fluoronicotinic acid methyl ester
2-Fluoronicotinic acid methyl ester
- CAS No.
- 446-26-4
- Chemical Name:
- 2-Fluoronicotinic acid methyl ester
- Synonyms
- methyl 2-fluoronicotinate;2-fluoronicotin methyl ester;2-Fluoronicotinic acid methyl ester;Methyl 2-fluoro-3-pyridinecarboxylate;Methyl 2-fluoropyridine-3-carboxylate;3-Pyridinecarboxylicacid, 2-fluoro-, methyl ester;2-FLUORONICOTINIC ACID METHYL ESTER ISO 9001：2015 REACH
- CBNumber:
- CB1327933
- Molecular Formula:
- C7H6FNO2
- Molecular Weight:
- 155.13
- MDL Number:
- MFCD03095072
- MOL File:
- 446-26-4.mol
- MSDS File:
- SDS
Last updated:2026-09-12 18:49:11
| Melting point | 22-26 °C |
|---|---|
| Boiling point | 75 °C/5 mmHg |
| Density | 1.243±0.06 g/cm3(Predicted) |
| Flash point | 110 °C |
| storage temp. | Inert atmosphere,Room Temperature |
| pka | -2.47±0.10(Predicted) |
| form | liquid |
| Appearance | Colorless to light yellow Liquid |
| InChI | 1S/C7H6FNO2/c1-11-7(10)5-3-2-4-9-6(5)8/h2-4H,1H3 |
| InChIKey | PJNHJXKXBSOLBH-UHFFFAOYSA-N |
| SMILES | COC(=O)c1cccnc1F |
| CAS DataBase Reference | 446-26-4(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 |
| target organs | Respiratory system |
| PPE | dust mask type N95 (US), Eyeshields, Gloves |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26 |
| WGK Germany | 3 |
| HS Code | 2933399990 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
2-Fluoronicotinic acid methyl ester price More Price(57)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 701904 | Methyl 2-fluoropyridine-3-carboxylate 97% | 446-26-4 | 1g | $163 | 2023-06-20 | Buy |
| Apolloscientific | PC201254 | Methyl 2-fluoronicotinate >98% | 446-26-4 | 5g | $26 | 2026-06-04 | Buy |
| Apolloscientific | PC201254 | Methyl 2-fluoronicotinate >98% | 446-26-4 | 25g | $104 | 2026-06-04 | Buy |
| Apolloscientific | PC201254 | Methyl 2-fluoronicotinate >98% | 446-26-4 | 100g | $342 | 2026-06-04 | Buy |
| Apolloscientific | PC201254 | Methyl 2-fluoronicotinate >98% | 446-26-4 | 500g | $1686 | 2026-06-04 | Buy |
2-Fluoronicotinic acid methyl ester Chemical Properties, Uses, Production
Synthesis
40134-18-7
446-26-4
GENERAL METHOD: To a solution of methyl 2-chloronicotinate (1.00 g, 6.76 mmol) in DMSO (33.8 mL) was added CsF (2.053 g, 13.51 mmol) at room temperature. The reaction mixture was stirred at 110 °C for 20 h in air. Upon completion of the reaction, the reaction mixture was quenched with ice water and extracted with EtOAc (3 × 20 mL). The organic layers were combined, washed sequentially with water and saturated brine, dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (eluent: hexane/EtOAc gradient elution) to afford methyl 2-fluoronicotinate (0.639 g, 4.86 mmol, 71.9% yield) as a colorless oil. The synthesis of compounds 3B'-8B' was carried out with reference to the preparation steps of 2B'.
References
[1] Tetrahedron Letters, 2015, vol. 56, # 44, p. 6043 - 6046
2-Fluoronicotinic acid methyl ester Preparation Products And Raw materials
Global Suppliers ( 152)
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| DKD Shijiazhuang Chemical Co., Ltd. | 0311-67790228 15531158659 | 2361184479@qq.com | China | 300 | 62 |
| Shenyang Comrade Chemical Co., Ltd. | +86(24) 31938773(O) | sales@co-chem.com | China | 225 | 62 |
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 13761987713 | hxzheng@sunwaypharm.cn | China | 8663 | 57 |
| Hunan Hui Bai Shi Biotechnology Co., Ltd. | 0731-85526065 13308475853 | ivy@hnhbsj.com | China | 7236 | 62 |
View Latest Price from 2-Fluoronicotinic acid methyl ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2022-02-23 | 2-FLUORONICOTINIC ACID METHYL ESTER
446-26-4
|
1KG | 98.3% | 100 tons | Honest Joy Holdings Limited | ||
 |
2021-08-12 | 2-FLUORONICOTINIC ACID METHYL ESTER
446-26-4
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2019-07-06 | 2-FLUORONICOTINIC ACID METHYL ESTER
446-26-4
|
$1.00 | 1kg | 99% | Career Henan Chemical Co |
-
- 2-FLUORONICOTINIC ACID METHYL ESTER
446-26-4
- $0.00
- 98.3%
- Honest Joy Holdings Limited
-
- 2-FLUORONICOTINIC ACID METHYL ESTER
446-26-4
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 2-FLUORONICOTINIC ACID METHYL ESTER
446-26-4
- $1.00
- 99%
- Career Henan Chemical Co
446-26-4 (2-Fluoronicotinic acid methyl ester) Related Search:
Methyl 2-fluoropyridine-3-carboxylate
2-fluoronicotin methyl ester
Methyl 2-fluoro-3-pyridinecarboxylate
3-Pyridinecarboxylicacid, 2-fluoro-, methyl ester
2-FLUORONICOTINIC ACID METHYL ESTER ISO 9001：2015 REACH
methyl 2-fluoronicotinate
2-Fluoronicotinic acid methyl ester
446-26-4
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