METHYL 2-CHLORONICOTINATE
- CAS No.
- 40134-18-7
- Chemical Name:
- METHYL 2-CHLORONICOTINATE
- Synonyms
- METHYL 2-CHLOROPYRIDINE-3-CARBOXYLATE;METHYL 2-CHLORONICOT;METHYL-2-CHLONICOTINATE;Methyl 2-chloronicotite;Mehyl 2-Chloronicotinate;METHYL 2-CHLORONICOTINATE;Methyl2-Chloronicotinate>Methyl 2-chloronicotinate 98%;2-CHLORONICOTINIC ACID METHYL ESTER;METHYL 2-CHLORO-3-PYRIDINECARBOXYLATE
- CBNumber:
- CB2317331
- Molecular Formula:
- C7H6ClNO2
- Molecular Weight:
- 171.58
- MDL Number:
- MFCD01318629
- MOL File:
- 40134-18-7.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Methyl 2-Chloronicotinate >98.0%(GC) | M2165 | 5g | $17 |
| Methyl 2-Chloronicotinate >98.0%(GC) | M2165 | 25g | $42 |
| Methyl 2-chloronicotinate | 454915 | 500mg | $305 |
| Methyl 2-Chloronicotinate | M295693 | 1g | $55 |
| Methyl 2-Chloronicotinate 98% | OR3350 | 100g | $56 |
| More product size | |||
| Boiling point | 150 °C/1 mmHg |
|---|---|
| Density | 1.314 g/mL at 25 °C |
| refractive index | n 20/D 1.537 |
| Flash point | 110 °C |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| pka | -1.39±0.10(Predicted) |
| form | Liquid |
| color | Colorless |
| CAS DataBase Reference | 40134-18-7(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H335-H319-H315 | |||||||||
| Precautionary statements | P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P280a-P304+P340-P405-P501a-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36 | |||||||||
| Safety Statements | 26 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant/Keep Cold | |||||||||
| HS Code | 2933399990 | |||||||||
| NFPA 704 |
|
METHYL 2-CHLORONICOTINATE price More Price(32)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | M2165 | Methyl 2-Chloronicotinate >98.0%(GC) | 40134-18-7 | 5g | $17 | 2026-03-19 | Buy |
| TCI Chemical | M2165 | Methyl 2-Chloronicotinate >98.0%(GC) | 40134-18-7 | 25g | $42 | 2026-03-19 | Buy |
| Usbiological | 454915 | Methyl 2-chloronicotinate | 40134-18-7 | 500mg | $305 | 2021-12-16 | Buy |
| TRC | M295693 | Methyl 2-Chloronicotinate | 40134-18-7 | 1g | $55 | 2021-12-16 | Buy |
| Apolloscientific | OR3350 | Methyl 2-Chloronicotinate 98% | 40134-18-7 | 100g | $56 | 2021-12-16 | Buy |
METHYL 2-CHLORONICOTINATE Chemical Properties,Uses,Production
Description
Methyl 2-chloronicotinate is used in proteomics studies.
Synthesis
67-56-1
2942-59-8
40134-18-7
(1) Preparation of methyl 2-chloronicotinate: 15.0 g (95.2 mmol) of 2-chloronicotinate was dissolved in 150 mL of dichloromethane and 8.37 mL (94.5 mmol) of oxalyl chloride was added slowly and dropwise. Subsequently, N,N-dimethylformamide was added dropwise to the mixture and the reaction mixture was stirred at room temperature for 3 hours. Upon completion of the reaction, 40.1 mL (286 mmol) of triethylamine and 37 mL (914 mmol) of methanol were added dropwise to the reaction mixture under ice-bath cooling conditions and stirring was continued for 30 minutes under ice-bath cooling. The reaction mixture was concentrated under reduced pressure and neutralized by adding aqueous sodium bicarbonate to the residue. The aqueous phase was extracted with ether, the organic phases were combined, washed with water, dried over anhydrous sodium sulfate, filtered and concentrated. The residue was purified by column chromatography (eluent: ethyl acetate/hexane=1:4) to afford 13.9 g of the target product methyl 2-chloronicotinate as a pale yellow liquid in 86% yield.1H-NMR (CDCl3/TMS, δ ppm): 3.97 (3H, s), 7.33 (1H, dd), 8.17 (1H, dd), 8.53 (1H, dd ).
References
[1] Patent: CN105061399, 2017, B. Location in patent: Paragraph 0010; 0029; 0030
[2] Patent: US2011/287937, 2011, A1. Location in patent: Page/Page column 72-73
[3] Patent: WO2007/71900, 2007, A1. Location in patent: Page/Page column 94
[4] Yakugaku Zasshi, 1952, vol. 72, p. 1336,1338
[5] Chem.Abstr., 1953, p. 4336
METHYL 2-CHLORONICOTINATE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Frapp's ChemicalNFTZ Co., Ltd. | +86 (576) 8169-6106 | sales@frappschem.com | China | 880 | 50 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29640 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29825 | 58 |
| Changzhou Ditong Chemical Co.,Ltd | +86-0519-88298848 | info@edengenechem.com | China | 2176 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| Richest Group Ltd | 18017061086 | oled@richest-group.com | CHINA | 5600 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10000 | 58 |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9636 | 58 |
View Lastest Price from METHYL 2-CHLORONICOTINATE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | METHYL 2-CHLORONICOTINATE
40134-18-7
|
US $1.00 / kg | 1kg | 99% | Customized | Career Henan Chemical Co |
-
- METHYL 2-CHLORONICOTINATE
40134-18-7
- US $1.00 / kg
- 99%
- Career Henan Chemical Co
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