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2-Fluoro-4-iodonicotinic acid methyl ester

2-Fluoro-4-iodonicotinic acid methyl ester structure

CAS No.: 884494-84-2

Chemical Name:: 2-Fluoro-4-iodonicotinic acid methyl ester

Synonyms: Methyl 2-Fluoro-4-iodonicotinate;2-Fluoro-4-iodonicotinic acid methyl ester;Methyl 2-Fluoro-4-iodopyridin-3-ylcarbanate;Methyl 2-fluoro-4-iodopyridine-3-carboxylate;2-Fluoro-4-iodo-3-pyridinecarboxylic acid methyl ester;3-PYRIDINECARBOXYLIC ACID, 2-FLUORO-4-IODO-,METHYL ESTER;Methyl 2-fluoro-4-iodopyridine-3-carboxylate, 2-Fluoro-4-iodo-3-(methoxycarbonyl)pyridine

CBNumber:: CB6468022

Molecular Formula:: C7H5FINO2

Molecular Weight:: 281.02

MDL Number:: MFCD04972401

MOL File:: 884494-84-2.mol

MSDS File:: SDS

Last updated:2026-09-12 18:54:16

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2-Fluoro-4-iodonicotinic acid methyl ester Properties

Boiling point	287℃
Density	1.913
Flash point	127℃
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
pka	-3.86±0.18(Predicted)
Appearance	White to off-white Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302+H312+H332-H315-H319-H335
Precautionary statements	P280
HS Code	2933399990

2-Fluoro-4-iodonicotinic acid methyl ester price More Price(50)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Apolloscientific	PC49357	Methyl 2-fluoro-4-iodonicotinate 97%	884494-84-2	250mg	$21	2026-06-04	Buy
Matrix Scientific	076498	Methyl 2-fluoro-4-iodonicotinate	884494-84-2	5.00g	$57	2026-05-18	Buy
Matrix Scientific	076498	Methyl 2-fluoro-4-iodonicotinate	884494-84-2	10.00g	$84	2026-05-18	Buy
Matrix Scientific	076498	Methyl 2-fluoro-4-iodonicotinate	884494-84-2	25.00g	$172	2026-05-18	Buy
Synthonix	M45002	Methyl 2-fluoro-4-iodonicotinate 97%	884494-84-2	100mg	$15	2026-05-06	Buy

Product number	Packaging	Price	Buy
PC49357	250mg	$21	Buy
076498	5.00g	$57	Buy
076498	10.00g	$84	Buy
076498	25.00g	$172	Buy
M45002	100mg	$15	Buy

2-Fluoro-4-iodonicotinic acid methyl ester Chemical Properties, Uses, Production

Uses

2-Fluoro-4-iodonicotinic acid methyl ester can be used as a pharmaceutical synthesis intermediate.

Synthesis

884494-51-3

18107-18-1

2-FLUORO-4-IODONICOTINIC ACID METHYL ESTER

884494-84-2

GENERAL STEPS: 2-Fluoro-4-iodonicotinic acid (5.13 g) was dissolved in a solvent mixture of ether (25 mL) and methanol (25 mL) under nitrogen protection. To this solution was slowly added a 10% hexane solution of trimethylsilylated diazomethane (32.9 g). The reaction mixture was stirred at room temperature for 3 hours. Upon completion of the reaction, the reaction solution was concentrated and the resulting residue was purified by silica gel column chromatography (eluent: hexane-ethyl acetate gradient) to afford methyl 2-fluoro-4-iodonicotinate (5.3 g). The structure of the product was confirmed by 1H NMR (300 MHz, DMSO-d6): δ 3.94 (3H, s), 7.98 (1H, dd, J = 5.3, 1.1 Hz), 8.07 (1H, dd, J = 5.3, 0.8 Hz).

References

[1] Patent: EP2921480, 2015, A1. Location in patent: Paragraph 0391; 0392
[2] Patent: WO2016/95204, 2016, A1. Location in patent: Page/Page column 62; 63

2-Fluoro-4-iodonicotinic acid methyl ester Preparation Products And Raw materials

Raw materials

2-Fluoro-4-iodonicotinic acid (Trimethylsilyl)diazomethane

Preparation Products

2-Fluoro-4-iodonicotinic acid methyl ester Suppliers

Global Suppliers ( 83)

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
Jia Xing Isenchem Co.,Ltd	0573-85285100 18627885956	isenchem@163.com	China	9389	66
Accela ChemBio Co.,Ltd.	021-50795510 4000665055	marketing@accelachem.com	China	10972	64
Shanghai Topbiochem Technology Co., Ltd	+86-21-60341587	sales@topbiochem.com	China	6166	58
Shanghai Jian Chao Chemical Technology Co., Ltd.	150-2103-5486 18017383231	983544897@qq.com	China	9335	55
SuZhou ShiYa Biopharmaceuticals, Inc.	86(512)5235 8471 17715136450	sales@shiyabiopharm.com	China	4167	58
Shanghai Yolne Chemical Co., Ltd.	021-62960152	934678158@qq.com	China	9886	55
Hebei Summedchem Co.,Ltd	0319-5801333-8008 15630992918	sales@summedchem.com	China	1000	58
Shanghai Hekang Biotechnology Co., Ltd.	17721021104 18939837085	2880152141@qq.com	China	1840	55

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
Capot Chemical Co., Ltd	66
Jia Xing Isenchem Co.,Ltd	66
Accela ChemBio Co.,Ltd.	64
Shanghai Topbiochem Technology Co., Ltd	58
Shanghai Jian Chao Chemical Technology Co., Ltd.	55
SuZhou ShiYa Biopharmaceuticals, Inc.	58
Shanghai Yolne Chemical Co., Ltd.	55
Hebei Summedchem Co.,Ltd	58
Shanghai Hekang Biotechnology Co., Ltd.	55

View Latest Price from 2-Fluoro-4-iodonicotinic acid methyl ester manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-07-06	2-FLUORO-4-IODONICOTINIC ACID METHYL ESTER 884494-84-2	$1.00	1kg	98%	200KG	Career Henan Chemical Co

2-FLUORO-4-IODONICOTINIC ACID METHYL ESTER
884494-84-2
$1.00
98%
Career Henan Chemical Co

2-Fluoro-4-iodonicotinic acid methyl ester Spectrum

2-FLUORO-4-IODONICOTINIC ACID METHYL ESTER(884494-84-2)¹HNMR

884494-84-2 (2-Fluoro-4-iodonicotinic acid methyl ester) Related Search:

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4-Iodo-2-fluoro-3-formylpyridine 2-Fluoronicotinic acid methyl ester 2-Fluoro-3-(hydroxymethyl)-4-iodopyridine 2-Fluoro-4-iodonicotinic acid methyl ester 2-Fluoro-4-iodonicotinic acid

2-Fluoro-4-iodo-3-picoline 2-Fluoro-3-formylpyridine 2-Fluoro-3-(hydroxymethyl)pyridine

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3-PYRIDINECARBOXYLIC ACID, 2-FLUORO-4-IODO-,METHYL ESTER Methyl 2-fluoro-4-iodopyridine-3-carboxylate Methyl 2-fluoro-4-iodopyridine-3-carboxylate, 2-Fluoro-4-iodo-3-(methoxycarbonyl)pyridine Methyl 2-Fluoro-4-iodopyridin-3-ylcarbanate 2-Fluoro-4-iodo-3-pyridinecarboxylic acid methyl ester Methyl 2-Fluoro-4-iodonicotinate 2-Fluoro-4-iodonicotinic acid methyl ester 884494-84-2 C7H5FINO2 Boronic Acid Heterocyclic Compounds